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Randomized Controlled Trial
. 2014 Apr;95(4):432-8.
doi: 10.1038/clpt.2013.241. Epub 2014 Jan 13.

Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects

S Misaka  1 , J Yatabe  2 , F Müller  3 , K Takano  2 , K Kawabe  4 , H Glaeser  3 , M S Yatabe  2 , S Onoue  4 , J P Werba  5 , H Watanabe  6 , S Yamada  4 , M F Fromm  3 , J Kimura  2
Affiliations
Randomized Controlled Trial

Green tea ingestion greatly reduces plasma concentrations of nadolol in healthy subjects

S Misaka et al. Clin Pharmacol Ther. 2014 Apr.

Abstract

This study aimed to evaluate the effects of green tea on the pharmacokinetics and pharmacodynamics of the β-blocker nadolol. Ten healthy volunteers received a single oral dose of 30 mg nadolol with green tea or water after repeated consumption of green tea (700 ml/day) or water for 14 days. Catechin concentrations in green tea and plasma were determined. Green tea markedly decreased the maximum plasma concentration (C(max)) and area under the plasma concentration-time curve (AUC(0-48)) of nadolol by 85.3% and 85.0%, respectively (P < 0.01), without altering renal clearance of nadolol. The effects of nadolol on systolic blood pressure were significantly reduced by green tea. [(3)H]-Nadolol uptake assays in human embryonic kidney 293 cells stably expressing the organic anion-transporting polypeptides OATP1A2 and OATP2B1 revealed that nadolol is a substrate of OATP1A2 (Michaelis constant (K(m)) = 84.3 μmol/l) but not of OATP2B1. Moreover, green tea significantly inhibited OATP1A2-mediated nadolol uptake (half-maximal inhibitory concentration, IC(50) = 1.36%). These results suggest that green tea reduces plasma concentrations of nadolol possibly in part by inhibition of OATP1A2-mediated uptake of nadolol in the intestine.

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