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Meta-Analysis
. 2020 Dec 17;10(1):22194.
doi: 10.1038/s41598-020-79216-y.

The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis

Mohammad Hassan Sohouli  1   2 , Elham Sharifi-Zahabi  1   2 , Abolfazl Lari  1   2 , Somaye Fatahi  1   2 , Farzad Shidfar  3   4
Affiliations
Meta-Analysis

The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis

Mohammad Hassan Sohouli et al. Sci Rep. .

Abstract

Several randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products diet on obesity and related hormones. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: Web of Science, Scopus, Ovid MEDLINE, Cochrane, and Embase up to October, 2019. From the eligible trials, 13 articles were selected for the systematic review and meta-analysis. Our systematic reviews and meta-analyses have shown a significant decrease in BMI (WMD: - 0.3 kg/m2; 95% CI: - 0.52, - 0.09, p = 0.005; I2 = 55.8%), weight (WMD: - 0.83 kg; 95% CI: - 1.55, - 0.10, p = 0.026; I2 = 67.0%), and leptin (WMD: - 19.85 ng/ml; 95% CI: - 29.88, - 9.82, p < 0.001; I2 = 81.8%) and an increase in adiponectin (WMD: 5.50 µg/ml; 95% CI: 1.33, 9.67, p = 0.010; I2 = 90.6%) levels after consumption of the low AGE diets compared to the high AGE diets. Also, the effect of intake of low AGE compared to high AGE diets was more pronounced in subgroup with duration > 8 weeks for the BMI and weight. Overall, according to our results, although low AGE diets appeared to be statistically significant in reducing the prevalence of obesity and chronic diseases compared to high consumption of dietary AGEs. But, no clinical significance was observed. Therefore, to confirm these results clinically, further prospective studies should be conducted in this regard. The study protocol was registered in the in International prospective register of systematic reviews (PROSPERO) database as CRD42020203734.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Flow chart of study selection process.
Figure 2
Figure 2
Forest plot of randomized controlled trials investigating the effects of low dietary AGEs on BMI.
Figure 3
Figure 3
Forest plot of randomized controlled trials investigating the effects of low dietary AGEs on weight.
Figure 4
Figure 4
Forest plot of randomized controlled trials investigating the effects of low dietary AGEs on WC.
Figure 5
Figure 5
Forest plot of randomized controlled trials investigating the effects of low dietary AGEs on leptin level.
Figure 6
Figure 6
Forest plot of randomized controlled trials investigating the effects of low dietary AGEs on adiponectin level.
See this image and copyright information in PMC

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