Leptin in human reproduction: serum leptin levels in pregnant and lactating women
- PMID: 9024259
- DOI: 10.1210/jcem.82.2.3731
Leptin in human reproduction: serum leptin levels in pregnant and lactating women
Abstract
Experiments in ob/ob female mice demonstrated that leptin injections not only reduced weight and fat mass, but also restored fertility and partial lactation. To explore factors regulating ob gene expression in reproductive women, we measured serum leptin, body fat, energy expenditure, and milk production in 65 women at 36 weeks of gestation, and at 3 and 6 months postpartum. Serum leptin was measured by solid-phase sandwich enzyme immunoassay, and serum insulin and PRL by solid-phase 125I RIA. Total body water by deuterium dilution, body volume by hydrodensitometry, and bone density by dual-energy x-ray absorptiometry were used to estimate body fat. Serum leptin per unit fat mass was significantly higher at 36 weeks of pregnancy than at 3 and 6 months postpartum (1.25 vs. 0.75, 0.73 ng.mL-1.kg-1). Postpartum normalization of leptin was associated with changes not only in weight and fat mass, but also serum insulin. Leptin was not different between lactating and nonlactating women. Leptin may have affected milk production indirectly through its negative effect on serum PRL. Adjusted for fat-free mass and fat mass, rates of energy expenditure were not significantly correlated with leptin. Our results provide evidence that factors other than fat mass alone modulate serum leptin in reproductive women.
Similar articles
-
Relationship of plasma leptin to plasma insulin and adiposity in normal weight and overweight women: effects of dietary fat content and sustained weight loss.J Clin Endocrinol Metab. 1996 Dec;81(12):4406-13. doi: 10.1210/jcem.81.12.8954050. J Clin Endocrinol Metab. 1996. PMID: 8954050
-
Leptin in postmenopausal women: influence of hormone therapy, insulin, and fat distribution.J Clin Endocrinol Metab. 2000 May;85(5):1770-5. doi: 10.1210/jcem.85.5.6602. J Clin Endocrinol Metab. 2000. PMID: 10843150
-
Adjustments in energy expenditure and substrate utilization during late pregnancy and lactation.Am J Clin Nutr. 1999 Feb;69(2):299-307. doi: 10.1093/ajcn/69.2.299. Am J Clin Nutr. 1999. PMID: 9989696
-
Leptin in human reproduction.Hum Reprod Update. 1999 Jan-Feb;5(1):52-63. doi: 10.1093/humupd/5.1.52. Hum Reprod Update. 1999. PMID: 10333369 Review.
-
Physiological roles of the leptin endocrine system: differences between mice and humans.Crit Rev Clin Lab Sci. 1999 Dec;36(6):575-655. doi: 10.1080/10408369991239259. Crit Rev Clin Lab Sci. 1999. PMID: 10656540 Review.
Cited by
-
Neurodevelopmental Programming of Adiposity: Contributions to Obesity Risk.Endocr Rev. 2024 Mar 4;45(2):253-280. doi: 10.1210/endrev/bnad031. Endocr Rev. 2024. PMID: 37971140 Free PMC article. Review.
-
Factors associated with the combination of general and abdominal obesity in middle-aged and older Korean women: a cross-sectional study.Osong Public Health Res Perspect. 2023 Oct;14(5):379-387. doi: 10.24171/j.phrp.2023.0089. Epub 2023 Sep 20. Osong Public Health Res Perspect. 2023. PMID: 37920895 Free PMC article.
-
Changes in Body Reserves, Non-Esterified Fatty Acids, and Leptin during the Reproductive Lifespan of the Rabbit Female.Animals (Basel). 2023 Oct 14;13(20):3213. doi: 10.3390/ani13203213. Animals (Basel). 2023. PMID: 37893936 Free PMC article.
-
Parental factors that impact the ecology of human mammary development, milk secretion, and milk composition-a report from "Breastmilk Ecology: Genesis of Infant Nutrition (BEGIN)" Working Group 1.Am J Clin Nutr. 2023 Apr;117 Suppl 1(Suppl 1):S11-S27. doi: 10.1016/j.ajcnut.2022.11.026. Am J Clin Nutr. 2023. PMID: 37173058 Free PMC article.
-
Metabolic effects of prolactin.Front Endocrinol (Lausanne). 2022 Sep 27;13:1015520. doi: 10.3389/fendo.2022.1015520. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36237192 Free PMC article. Review.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous