Memory B cells and CD27
- PMID: 10809378
- DOI: 10.14670/HH-15.573
Memory B cells and CD27
Abstract
Following antigen activation in germinal centers, B cells develop into memory B cells or plasma cells. Triggering via B-cell immunoglobulin receptors by antigens, cytokines and direct cell-to-cell contact by B and T cells plays an important role in the B cell differentiation into memory or plasma cells. Adult human peripheral blood B cells are separated into three subtypes by the expression of IgD and CD27, which belong to the tumor necrosis factor receptor (TNFR) family: IgD+ CD27- naive B cells, IgD+ CD27+ and IgD- CD27+ B cells. CD27+ B cells are larger cells with abundant cytoplasm carrying somatic hypermutation, and have an ability to produce immunoglobulin, indicating that CD27 is a memory marker of B cells. The ligation of CD27 yields crucial signals that positively control the entry of B cells into the pathway to plasma cells. We review observations on subpopulations and differentiation of mature B-cells by T/B cell interaction via CD27/CD70 as compared with CD40/CD154 interaction, and discuss about memory B cells.
Similar articles
-
Metabolic Reprogramming Commits Differentiation of Human CD27+IgD+ B Cells to Plasmablasts or CD27-IgD- Cells.J Immunol. 2017 Jul 15;199(2):425-434. doi: 10.4049/jimmunol.1601908. Epub 2017 Jun 16. J Immunol. 2017. PMID: 28626065
-
CD27/CD70 interactions regulate T dependent B cell differentiation.Immunol Res. 2000;21(1):23-30. doi: 10.1385/IR:21:1:23. Immunol Res. 2000. PMID: 10803880 Review.
-
Plasma cell generation from B-lymphocytes via CD27/CD70 interaction.Leuk Lymphoma. 1999 Oct;35(3-4):219-25. doi: 10.3109/10428199909145724. Leuk Lymphoma. 1999. PMID: 10706444 Review.
-
Human immunoglobulin (Ig)M+IgD+ peripheral blood B cells expressing the CD27 cell surface antigen carry somatically mutated variable region genes: CD27 as a general marker for somatically mutated (memory) B cells.J Exp Med. 1998 Nov 2;188(9):1679-89. doi: 10.1084/jem.188.9.1679. J Exp Med. 1998. PMID: 9802980 Free PMC article.
-
B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production.Eur J Immunol. 1997 Aug;27(8):2073-9. doi: 10.1002/eji.1830270835. Eur J Immunol. 1997. PMID: 9295047
Cited by
-
Synergistic B and T lymphocyte interaction: prognostic implications in non-small cell lung cancer.Am J Cancer Res. 2024 Mar 15;14(3):1227-1242. doi: 10.62347/TDIV2436. eCollection 2024. Am J Cancer Res. 2024. PMID: 38590414 Free PMC article.
-
Beyond CTLA-4 and PD-1 Inhibition: Novel Immune Checkpoint Molecules for Melanoma Treatment.Cancers (Basel). 2023 May 11;15(10):2718. doi: 10.3390/cancers15102718. Cancers (Basel). 2023. PMID: 37345056 Free PMC article. Review.
-
Single-cell sequencing reveals the evolution of immune molecules across multiple vertebrate species.J Adv Res. 2024 Jan;55:73-87. doi: 10.1016/j.jare.2023.02.017. Epub 2023 Mar 4. J Adv Res. 2024. PMID: 36871615 Free PMC article.
-
Innate and Adaptive Immunity during SARS-CoV-2 Infection: Biomolecular Cellular Markers and Mechanisms.Vaccines (Basel). 2023 Feb 10;11(2):408. doi: 10.3390/vaccines11020408. Vaccines (Basel). 2023. PMID: 36851285 Free PMC article. Review.
-
Flow cytometry as a fast, cost-effective tool to assess IGHV mutational status in CLL.Blood Adv. 2023 Sep 12;7(17):4701-4704. doi: 10.1182/bloodadvances.2022008033. Blood Adv. 2023. PMID: 36287221 Free PMC article. No abstract available.
Publication types
MeSH terms
Substances
LinkOut - more resources
Other Literature Sources
Molecular Biology Databases
Research Materials