Critical periods for experience-dependent synaptic scaling in visual cortex
- PMID: 12080341
- DOI: 10.1038/nn878
Critical periods for experience-dependent synaptic scaling in visual cortex
Abstract
The mechanisms underlying experience-dependent plasticity and refinement of central circuits are not yet fully understood. A non-Hebbian form of synaptic plasticity, which scales synaptic strengths up or down to stabilize firing rates, has recently been discovered in cultured neuronal networks. Here we demonstrate the existence of a similar mechanism in the intact rodent visual cortex. The frequency of miniature excitatory postsynaptic currents (mEPSCs) in principal neurons increased steeply between post-natal days 12 and 23. There was a concomitant decrease in mEPSC amplitude, which was prevented by rearing rats in complete darkness from 12 days of age. In addition, as little as two days of monocular deprivation scaled up mEPSC amplitude in a layer- and age-dependent manner. These data indicate that mEPSC amplitudes can be globally scaled up or down as a function of development and sensory experience, and suggest that synaptic scaling may be involved in the activity-dependent refinement of cortical connectivity.
Comment in
-
Synapses, scaling and homeostasis in vivo.Nat Neurosci. 2002 Aug;5(8):712-4. doi: 10.1038/nn0802-712. Nat Neurosci. 2002. PMID: 12149621 No abstract available.
Similar articles
-
The age of plasticity: developmental regulation of synaptic plasticity in neocortical microcircuits.Prog Brain Res. 2008;169:211-23. doi: 10.1016/S0079-6123(07)00012-X. Prog Brain Res. 2008. PMID: 18394476 Review.
-
Increase in AMPA receptor-mediated miniature EPSC amplitude after chronic NMDA receptor blockade in cultured hippocampal neurons.Neurosci Lett. 2007 May 11;418(1):4-8. doi: 10.1016/j.neulet.2007.02.058. Epub 2007 Mar 1. Neurosci Lett. 2007. PMID: 17395372
-
Activity- and BDNF-induced plasticity of miniature synaptic currents in ES cell-derived neurons integrated in a neocortical network.J Neurophysiol. 2005 Dec;94(6):4538-43. doi: 10.1152/jn.00155.2005. J Neurophysiol. 2005. PMID: 16293594
-
[Critical period of cortical plasticity].Rev Neurol. 2003 Oct 16-31;37(8):739-43. Rev Neurol. 2003. PMID: 14593633 Review. Spanish.
-
Activity-dependent scaling of quantal amplitude in neocortical neurons.Nature. 1998 Feb 26;391(6670):892-6. doi: 10.1038/36103. Nature. 1998. PMID: 9495341
Cited by
-
Progressive Circuit Hyperexcitability in Mouse Neocortical Slice Cultures with Increasing Duration of Activity Silencing.eNeuro. 2024 May 8;11(5):ENEURO.0362-23.2024. doi: 10.1523/ENEURO.0362-23.2024. Print 2024 May. eNeuro. 2024. PMID: 38653560 Free PMC article.
-
Developmental trajectory of cortical somatostatin interneuron function.bioRxiv [Preprint]. 2024 Mar 7:2024.03.05.583539. doi: 10.1101/2024.03.05.583539. bioRxiv. 2024. PMID: 38496673 Free PMC article. Preprint.
-
Transcranial Low-Intensity Focused Ultrasound Stimulation of the Visual Thalamus Produces Long-Term Depression of Thalamocortical Synapses in the Adult Visual Cortex.J Neurosci. 2024 Mar 13;44(11):e0784232024. doi: 10.1523/JNEUROSCI.0784-23.2024. J Neurosci. 2024. PMID: 38316559
-
Serotonergic Modulation of the Excitation/Inhibition Balance in the Visual Cortex.Int J Mol Sci. 2023 Dec 30;25(1):519. doi: 10.3390/ijms25010519. Int J Mol Sci. 2023. PMID: 38203689 Free PMC article.
-
Loss of Depalmitoylation Disrupts Homeostatic Plasticity of AMPARs in a Mouse Model of Infantile Neuronal Ceroid Lipofuscinosis.J Neurosci. 2023 Dec 6;43(49):8317-8335. doi: 10.1523/JNEUROSCI.1113-23.2023. J Neurosci. 2023. PMID: 37884348 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
