Nonsmoking-related arylamine exposure and bladder cancer risk
- PMID: 12814994
Nonsmoking-related arylamine exposure and bladder cancer risk
Abstract
Roughly one-half of bladder cancer incidence in the United States can be attributed to known causes, mainly cigarette smoking, and it has been hypothesized that the aromatic amines in tobacco smoke are important etiological agents. Nonsmokers are also exposed, through unknown sources, to many of the same carcinogenic aromatic amines that are present in cigarette smoke. Previous epidemiological studies have not tested whether either of these aromatic amine exposures are associated with cancer risk. We conducted a population-based case-control study in Los Angeles County, California, involving 761 case patients with bladder cancer and 770 individually matched control subjects. In-person interviews provided information on tobacco smoking and other potential risk factors. Quantitative analysis of hemoglobin adducts of 4- and 3-aminobiphenyl (ABP) was used to assess aromatic amine exposure. Adducts of both aminobiphenyls were significantly higher in cases than in controls, independent of cigarette smoking at the time of blood collection and lifetime smoking history. Adjustment for other risk factors as well as for metabolic differences did not materially alter the associations. Our findings strengthen the connection between exposure to aromatic amines in tobacco smoke and cigarette smoking-related bladder cancer and suggest that environmental exposure to arylamines may account for a significant proportion of nonsmoking-related bladder cancer in the general population.
Similar articles
-
Environmental tobacco smoke and bladder cancer risk in never smokers of Los Angeles County.Cancer Res. 2007 Aug 1;67(15):7540-5. doi: 10.1158/0008-5472.CAN-07-0048. Cancer Res. 2007. PMID: 17671226
-
Alkylaniline-hemoglobin adducts and risk of non-smoking-related bladder cancer.J Natl Cancer Inst. 2004 Oct 6;96(19):1425-31. doi: 10.1093/jnci/djh274. J Natl Cancer Inst. 2004. PMID: 15467031
-
A prospective cohort study of bladder cancer risk in relation to active cigarette smoking and household exposure to secondhand cigarette smoke.Am J Epidemiol. 2007 Mar 15;165(6):660-6. doi: 10.1093/aje/kwk047. Epub 2007 Jan 4. Am J Epidemiol. 2007. PMID: 17204516
-
Aromatic amines and human urinary bladder cancer: exposure sources and epidemiology.J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2003 May;21(1):29-43. doi: 10.1081/GNC-120021372. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2003. PMID: 12826031 Review.
-
Genotoxicity of tobacco smoke-derived aromatic amines and bladder cancer: current state of knowledge and future research directions.FASEB J. 2013 Jun;27(6):2090-100. doi: 10.1096/fj.12-227074. Epub 2013 Feb 28. FASEB J. 2013. PMID: 23449930 Review.
Cited by
-
Systematic Evaluation of Imaging Features of Early Bladder Cancer Using Computed Tomography Performed before Pathologic Diagnosis.Tomography. 2023 Sep 11;9(5):1734-1744. doi: 10.3390/tomography9050138. Tomography. 2023. PMID: 37736991 Free PMC article.
-
Tobacco Smoke Is a Major Source of Aromatic Amine Exposure in U.S. Adults: 2013-2014 National Health and Nutrition Examination Survey (NHANES).Cancer Epidemiol Biomarkers Prev. 2023 May 17:OF1-OF9. doi: 10.1158/1055-9965.EPI-23-0071. Online ahead of print. Cancer Epidemiol Biomarkers Prev. 2023. PMID: 37195136
-
Short- and Long-Term Stability of Aromatic Amines in Human Urine.Int J Environ Res Public Health. 2023 Feb 25;20(5):4135. doi: 10.3390/ijerph20054135. Int J Environ Res Public Health. 2023. PMID: 36901145 Free PMC article.
-
Variability in urinary concentrations of primary aromatic amines.Sci Total Environ. 2022 Jul 20;831:154768. doi: 10.1016/j.scitotenv.2022.154768. Epub 2022 Mar 24. Sci Total Environ. 2022. PMID: 35341833 Free PMC article.
-
Quo vadis blood protein adductomics?Arch Toxicol. 2022 Jan;96(1):79-103. doi: 10.1007/s00204-021-03165-2. Epub 2021 Nov 13. Arch Toxicol. 2022. PMID: 34773488 Free PMC article. Review.