doi: 10.1016/0014-5793(92)80616-o.
Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress
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- PMID: 1618322
- DOI: 10.1016/0014-5793(92)80616-o
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Cyclosporin A protects hepatocytes subjected to high Ca2+ and oxidative stress
FEBS Lett.
.
Free article
Abstract
Hepatocytes incubated with 0.8 mM t-butylhydroperoxide are protected by cyclosporin A when the medium Ca2+ concentration is 10 mM, but not when it is 2.5 mM. The highest Ca2+ level is associated with an inhibition of t-butylhydroperoxide-dependent malondialdehyde accumulation and with mitochondrial Ca2+ loading within the cells. These findings are new evidence that t-butylhydroperoxide can kill cells by peroxidation-dependent and -independent mechanisms, and suggest that the mitochondrial permeability transition and the resultant de-energization are components of the peroxidation-independent mechanism. Cyclosporin A may have considerable utility for the protection of cells subjected to oxidative stress.
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