Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
- PMID: 16408039
- DOI: 10.1038/nchembio727
Cytochrome c acts as a cardiolipin oxygenase required for release of proapoptotic factors
Abstract
Programmed death (apoptosis) is turned on in damaged or unwanted cells to secure their clean and safe self-elimination. The initial apoptotic events are coordinated in mitochondria, whereby several proapoptotic factors, including cytochrome c, are released into the cytosol to trigger caspase cascades. The release mechanisms include interactions of B-cell/lymphoma 2 family proteins with a mitochondria-specific phospholipid, cardiolipin, to cause permeabilization of the outer mitochondrial membrane. Using oxidative lipidomics, we showed that cardiolipin is the only phospholipid in mitochondria that undergoes early oxidation during apoptosis. The oxidation is catalyzed by a cardiolipin-specific peroxidase activity of cardiolipin-bound cytochrome c. In a previously undescribed step in apoptosis, we showed that oxidized cardiolipin is required for the release of proapoptotic factors. These results provide insight into the role of reactive oxygen species in triggering the cell-death pathway and describe an early role for cytochrome c before caspase activation.
Comment in
-
Cardiolipin oxidation sets cytochrome c free.Nat Chem Biol. 2005 Sep;1(4):188-9. doi: 10.1038/nchembio0905-188. Nat Chem Biol. 2005. PMID: 16408030 No abstract available.
Similar articles
-
Loss of cardiolipin in palmitate-treated GL15 glioblastoma cells favors cytochrome c release from mitochondria leading to apoptosis.J Neurochem. 2008 May;105(3):1019-31. doi: 10.1111/j.1471-4159.2007.05209.x. Epub 2007 Dec 24. J Neurochem. 2008. PMID: 18182042
-
Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis.Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):176-86. doi: 10.1016/j.ijrobp.2007.03.043. Int J Radiat Oncol Biol Phys. 2007. PMID: 17707271
-
Mitochondria, oxidative stress and cell death.Apoptosis. 2007 May;12(5):913-22. doi: 10.1007/s10495-007-0756-2. Apoptosis. 2007. PMID: 17453160 Review.
-
The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes.Chem Biol Interact. 2006 Oct 27;163(1-2):15-28. doi: 10.1016/j.cbi.2006.04.019. Epub 2006 May 12. Chem Biol Interact. 2006. PMID: 16797512 Review.
-
Oxidative lipidomics of apoptosis: redox catalytic interactions of cytochrome c with cardiolipin and phosphatidylserine.Free Radic Biol Med. 2004 Dec 15;37(12):1963-85. doi: 10.1016/j.freeradbiomed.2004.08.016. Free Radic Biol Med. 2004. PMID: 15544916 Review.
Cited by
-
The Role of Cardiolipin in Mitochondrial Function and Neurodegenerative Diseases.Cells. 2024 Mar 30;13(7):609. doi: 10.3390/cells13070609. Cells. 2024. PMID: 38607048 Free PMC article. Review.
-
Roles of reactive oxygen species in inflammation and cancer.MedComm (2020). 2024 Apr 4;5(4):e519. doi: 10.1002/mco2.519. eCollection 2024 Apr. MedComm (2020). 2024. PMID: 38576456 Free PMC article. Review.
-
Phosphorylations and Acetylations of Cytochrome c Control Mitochondrial Respiration, Mitochondrial Membrane Potential, Energy, ROS, and Apoptosis.Cells. 2024 Mar 12;13(6):493. doi: 10.3390/cells13060493. Cells. 2024. PMID: 38534337 Free PMC article. Review.
-
An Update of Kaempferol Protection against Brain Damage Induced by Ischemia-Reperfusion and by 3-Nitropropionic Acid.Molecules. 2024 Feb 8;29(4):776. doi: 10.3390/molecules29040776. Molecules. 2024. PMID: 38398528 Free PMC article. Review.
-
Iron homeostasis and post-hemorrhagic hydrocephalus: a review.Front Neurol. 2024 Jan 12;14:1287559. doi: 10.3389/fneur.2023.1287559. eCollection 2023. Front Neurol. 2024. PMID: 38283681 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
