Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi
- PMID: 17011546
- DOI: 10.1016/j.ejphar.2006.08.034
Adolescents differ from adults in cocaine conditioned place preference and cocaine-induced dopamine in the nucleus accumbens septi
Abstract
In humans, adolescent exposure to illicit drugs predicts the onset of adult drug abuse and suggests that early drug use potentiates vulnerability to drug addiction. Cocaine conditioned place preferences were measured in early adolescent [postnatal day (PND) 35], late adolescent (PND 45) and young adult (PND 60) rats by injecting either 0, 5 or 20 mg/kg cocaine and conditioning them to environmental cues. Cocaine preferences were found for all ages at the high dose. PND 35s were the only age group to have a preference at the low dose. To address whether age-related differences in cocaine place preferences were related to differences in the mesolimbic dopaminergic system, we measured extracellular dopamine levels in the nucleus accumbens septi of PND 35, PND 45 and PND 60 rats via quantitative microdialysis under transient conditions. Rats were injected daily with either 5 mg/kg/ip or saline for 4 days and surgically implanted with a microdialysis probe aimed at the nucleus accumbens. Rats were perfused with either 0, 1, 10 or 40 nM dopamine and the extracellular dopamine concentration was measured. Our results show that adolescents differ from adults in basal dopamine. All cocaine treated rats, regardless of age, showed a significant increase in dopamine over baseline in response to a cocaine challenge. Additionally, there were age-related differences in the extraction fraction (E(d)), an indirect measure of dopamine reuptake. Together these findings suggest ontogenetic differences in extracellular dopamine and dopamine reuptake and that these differences may provide an explanation for adolescent vulnerability to addiction.
Similar articles
-
Neurokinin3 receptor modulation of the behavioral and neurochemical effects of cocaine in rats and monkeys.Rev Neurosci. 2008;19(2-3):101-11. doi: 10.1515/revneuro.2008.19.2-3.101. Rev Neurosci. 2008. PMID: 18751518 Review.
-
Chronic ethanol exposure during adolescence increases basal dopamine in the nucleus accumbens septi during adulthood.Alcohol Clin Exp Res. 2007 May;31(5):895-900. doi: 10.1111/j.1530-0277.2007.00370.x. Epub 2007 Mar 28. Alcohol Clin Exp Res. 2007. PMID: 17391340
-
Neurochemical effects of cocaine in adolescence compared to adulthood.Brain Res Dev Brain Res. 2005 Oct 6;159(2):119-25. doi: 10.1016/j.devbrainres.2005.07.005. Brain Res Dev Brain Res. 2005. PMID: 16112203
-
Developmental differences in the accumbal dopaminergic response to repeated ethanol exposure.Ann N Y Acad Sci. 2004 Jun;1021:422-6. doi: 10.1196/annals.1308.056. Ann N Y Acad Sci. 2004. PMID: 15251921
-
Neuropharmacological mechanisms of drug reward: beyond dopamine in the nucleus accumbens.Crit Rev Neurobiol. 1998;12(1-2):37-67. doi: 10.1615/critrevneurobiol.v12.i1-2.30. Crit Rev Neurobiol. 1998. PMID: 9444481 Review.
Cited by
-
Cocaine reward and reinstatement in adolescent versus adult rodents.Front Behav Neurosci. 2024 Jan 5;17:1278263. doi: 10.3389/fnbeh.2023.1278263. eCollection 2023. Front Behav Neurosci. 2024. PMID: 38249124 Free PMC article. Review.
-
Investigating the Modulation of the VTA Neurons in Nicotine-Exposed Pups during Early Maturation Using Optogenetics.Int J Mol Sci. 2023 Jan 23;24(3):2280. doi: 10.3390/ijms24032280. Int J Mol Sci. 2023. PMID: 36768606 Free PMC article.
-
Binge eating and psychostimulant addiction.World J Psychiatry. 2021 Sep 19;11(9):517-529. doi: 10.5498/wjp.v11.i9.517. eCollection 2021 Sep 19. World J Psychiatry. 2021. PMID: 34631457 Free PMC article. Review.
-
Sexual Differentiation and Substance Use: A Mini-Review.Endocrinology. 2020 Sep 1;161(9):bqaa129. doi: 10.1210/endocr/bqaa129. Endocrinology. 2020. PMID: 32761086 Free PMC article. Review.
-
Role of adolescent-formed, context-drug-associations on reinstatement of drug-seeking behavior in rats.Psychopharmacology (Berl). 2020 Sep;237(9):2823-2833. doi: 10.1007/s00213-020-05575-z. Epub 2020 Jun 29. Psychopharmacology (Berl). 2020. PMID: 32601989 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Medical