A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins
- PMID: 17266926
- DOI: 10.1016/j.bbrc.2007.01.003
A component of green tea, (-)-epigallocatechin-3-gallate, promotes apoptosis in T24 human bladder cancer cells via modulation of the PI3K/Akt pathway and Bcl-2 family proteins
Abstract
Bladder cancer is the fourth most common cancer in men and ninth most common in women. It has a protracted course of progression and is thus an ideal candidate for chemoprevention strategies and trials. This study was conducted to evaluate the chemopreventive/antiproliferative potential of (-)-epigallocatechin gallate (EGCG, the major phytochemical in green tea) against bladder cancer and its mechanism of action. Using the T24 human bladder cancer cell line, we found that EGCG treatment caused dose- and time-dependent inhibition of cellular proliferation and cell viability, and induced apoptosis. Mechanistically, EGCG inhibits phosphatidylinositol 3'-kinase/Akt activation that, in turn, results in modulation of Bcl-2 family proteins, leading to enhanced apoptosis of T24 cells. These findings suggest that EGCG may be an important chemoprevention agent for the management of bladder cancer.
Similar articles
-
Epigallocatechin-3 gallate induces growth inhibition and apoptosis in human breast cancer cells through survivin suppression.Int J Oncol. 2007 Oct;31(4):705-11. Int J Oncol. 2007. PMID: 17786300
-
Tea polyphenol (-)-epigallocatechin 3-gallate suppresses heregulin-beta1-induced fatty acid synthase expression in human breast cancer cells by inhibiting phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase cascade signaling.J Agric Food Chem. 2007 Jun 27;55(13):5030-7. doi: 10.1021/jf070316r. Epub 2007 Jun 1. J Agric Food Chem. 2007. PMID: 17539658
-
Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer.Life Sci. 2006 Nov 17;79(25):2329-36. doi: 10.1016/j.lfs.2006.07.036. Epub 2006 Aug 5. Life Sci. 2006. PMID: 16945390 Review.
-
Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.Cancer Res. 2006 Mar 1;66(5):2500-5. doi: 10.1158/0008-5472.CAN-05-3636. Cancer Res. 2006. PMID: 16510563 Review.
-
Green tea component, catechin, induces apoptosis of human malignant B cells via production of reactive oxygen species.Clin Cancer Res. 2005 Aug 15;11(16):6040-9. doi: 10.1158/1078-0432.CCR-04-2273. Clin Cancer Res. 2005. PMID: 16115949
Cited by
-
Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications.Molecules. 2023 Jul 6;28(13):5246. doi: 10.3390/molecules28135246. Molecules. 2023. PMID: 37446908 Free PMC article. Review.
-
Resveratrol, Epigallocatechin Gallate and Curcumin for Cancer Therapy: Challenges from Their Pro-Apoptotic Properties.Life (Basel). 2023 Jan 17;13(2):261. doi: 10.3390/life13020261. Life (Basel). 2023. PMID: 36836619 Free PMC article. Review.
-
The Antagonistic Effect of Glutamine on Zearalenone-Induced Apoptosis via PI3K/Akt Signaling Pathway in IPEC-J2 Cells.Toxins (Basel). 2021 Dec 12;13(12):891. doi: 10.3390/toxins13120891. Toxins (Basel). 2021. PMID: 34941728 Free PMC article.
-
EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction.Nat Commun. 2021 Feb 12;12(1):986. doi: 10.1038/s41467-021-21258-5. Nat Commun. 2021. PMID: 33579943 Free PMC article.
-
Chemopreventive Property of Sencha Tea Extracts towards Sensitive and Multidrug-Resistant Leukemia and Multiple Myeloma Cells.Biomolecules. 2020 Jul 4;10(7):1000. doi: 10.3390/biom10071000. Biomolecules. 2020. PMID: 32635587 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical