Maternal obesity is necessary for programming effect of high-fat diet on offspring
- PMID: 19244583
- PMCID: PMC2689819
- DOI: 10.1152/ajpregu.91015.2008
Maternal obesity is necessary for programming effect of high-fat diet on offspring
Abstract
We tested the hypothesis that maternal consumption of dietary fat, independent from obesity, increases serum leptin in neonatal pups and predisposes them to adult obesity. Female rats either were fed a high-fat (HF) diet or a low-fat (LF) diet or were fed the HF diet but pair fed (PF) to the caloric intake of the LF group for 4 wk before breeding and throughout gestation and lactation. Dams consuming the HF diet had increased adiposity and were hyperphagic. At weaning, pups born to obese dams had significantly higher body fat and serum leptin levels and reduced insulin tolerance compared with offspring of LF-fed dams. Pups were weaned onto a chow diet until 8 wk of age, when they were then fed either HF or LF diet. At 18 wk of age, offspring from obese HF dams weighed more than offspring from nonobese LF or PF dams, and offspring eating HF diet weighed significantly more than those eating LF diet. Consequently, HF-fed offspring of obese HF dams weighed the most and LF-fed offspring from obese HF dams were similar in weight to HF-fed offspring from nonobese LF dams. These data suggest that maternal obesity exerts an independent effect on offspring body weight that is of similar magnitude as the effect of the offspring's adult diet. Furthermore, there was no difference in body weight between the nonobese LF and PF offspring on either diet. Together, these data suggest that maternal adiposity, and not dietary fat per se, induces hyperleptinemia and insulin resistance in offspring, as well as an increased body weight that persists into adulthood.
Figures
![Fig. 1.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650001.gif)
![Fig. 2.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650002.gif)
![Fig. 3.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650003.gif)
![Fig. 4.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650004.gif)
![Fig. 5.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650005.gif)
![Fig. 6.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650006.gif)
![Fig. 7.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650007.gif)
![Fig. 8.](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/2689819/bin/zh60050967650008.gif)
Similar articles
-
In utero nutritional stress as a cause of obesity: Altered relationship between body fat, leptin levels and caloric intake in offspring into adulthood.Life Sci. 2020 Aug 1;254:117764. doi: 10.1016/j.lfs.2020.117764. Epub 2020 May 12. Life Sci. 2020. PMID: 32407841 Free PMC article.
-
Early postweaning exercise improves central leptin sensitivity in offspring of rat dams fed high-fat diet during pregnancy and lactation.Am J Physiol Regul Integr Comp Physiol. 2013 Nov 1;305(9):R1076-84. doi: 10.1152/ajpregu.00566.2012. Epub 2013 Sep 11. Am J Physiol Regul Integr Comp Physiol. 2013. PMID: 24026073 Free PMC article.
-
Maternal high fat diet consumption during the perinatal period programs offspring behavior.Physiol Behav. 2014 Jan 17;123:236-42. doi: 10.1016/j.physbeh.2012.07.014. Epub 2012 Oct 17. Physiol Behav. 2014. PMID: 23085399 Free PMC article. Review.
-
A systematic review on animal models of maternal high fat feeding and offspring glycaemic control.Int J Obes (Lond). 2011 Mar;35(3):325-35. doi: 10.1038/ijo.2010.149. Epub 2010 Aug 3. Int J Obes (Lond). 2011. PMID: 20680016 Review.
-
Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet.J Physiol. 2009 Feb 15;587(Pt 4):905-15. doi: 10.1113/jphysiol.2008.163477. Epub 2008 Dec 22. J Physiol. 2009. PMID: 19103681 Free PMC article.
Cited by
-
Maternal and Child Health, Non-Communicable Diseases and Metabolites.Metabolites. 2023 Jun 15;13(6):756. doi: 10.3390/metabo13060756. Metabolites. 2023. PMID: 37367913 Free PMC article. Review.
-
Maternal obesity driven changes in collagen linearity of breast extracellular matrix induces invasive mammary epithelial cell phenotype.Biomaterials. 2023 Jun;297:122110. doi: 10.1016/j.biomaterials.2023.122110. Epub 2023 Apr 8. Biomaterials. 2023. PMID: 37062214 Free PMC article.
-
A comprehensive approach to modeling maternal immune activation in rodents.Front Neurosci. 2022 Dec 16;16:1071976. doi: 10.3389/fnins.2022.1071976. eCollection 2022. Front Neurosci. 2022. PMID: 36590294 Free PMC article. Review.
-
The metabolic conditioning of obesity: A review of the pathogenesis of obesity and the epigenetic pathways that "program" obesity from conception.Front Endocrinol (Lausanne). 2022 Oct 18;13:1032491. doi: 10.3389/fendo.2022.1032491. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36329895 Free PMC article. Review.
-
Short Communication: Maternal obesity alters ovine endometrial gene expression during peri-implantation development.J Anim Sci. 2022 Jul 1;100(7):skac090. doi: 10.1093/jas/skac090. J Anim Sci. 2022. PMID: 35772750 Free PMC article.
References
-
- Adair LS Child and adolescent obesity: epidemiology and developmental perspectives. Physiol Behav 94: 8–16, 2008. - PubMed
-
- Aslan H, Altunkaynak BZ, Altunkaynak ME, Vuraler O, Kaplan S, Unal B. Effect of a high fat diet on quantitative features of adipocytes in the omentum: an experimental, stereological and ultrastructural study. Obes Surg 16: 1526–1534, 2006. - PubMed
-
- Bayol SA, Farrington SJ, Stickland NC. A maternal “junk food” diet in pregnancy and lactation promotes an exacerbated taste for “junk food” and a greater propensity for obesity in rat offspring. Br J Nutr 98: 843–851, 2007. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials
Miscellaneous