Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Aug;21(6):593-8.
doi: 10.1016/j.semcdb.2009.12.012. Epub 2010 Jan 4.

OPA1 (dys)functions

Thomas Landes  1 , Ingrid Leroy, Ambre Bertholet, Alan Diot, Farnoosh Khosrobakhsh, Marlène Daloyau, Noélie Davezac, Marie-Christine Miquel, Delphine Courilleau, Emmanuelle Guillou, Aurélien Olichon, Guy Lenaers, Laetitia Arnauné-Pelloquin, Laurent J Emorine, Pascale Belenguer
Affiliations
Review

OPA1 (dys)functions

Thomas Landes et al. Semin Cell Dev Biol. 2010 Aug.

Abstract

Mitochondrial morphology varies according to cell type and cellular context from an interconnected filamentous network to isolated dots. This morphological plasticity depends on mitochondrial dynamics, a balance between antagonistic forces of fission and fusion. DRP1 and FIS1 control mitochondrial outer membrane fission and Mitofusins its fusion. This review focuses on OPA1, one of the few known actors of inner membrane dynamics, whose mutations provoke an optic neuropathy. Since its first identification in 2000 the characterization of the functions of OPA1 has made rapid progress thus providing numerous clues to unravel the pathogenetic mechanisms of ADOA-1.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

Publication types

LinkOut - more resources

-