Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2010 Mar;60(3):229-37.
doi: 10.1016/j.jinf.2010.01.003. Epub 2010 Jan 18.

Clinical, epidemiological and virological features of Dengue virus infections in Vietnamese patients presenting to primary care facilities with acute undifferentiated fever

Khoa T D Thai  1 , Hoang Lan Phuong, Tran Thi Thanh Nga, Phan Trong Giao, Le Quoc Hung, Nguyen Van Nam, Tran Quang Binh, Cameron Simmons, Jeremy Farrar, Tran Thinh Hien, H Rogier van Doorn, Menno D de Jong, Peter J de Vries
Affiliations

Clinical, epidemiological and virological features of Dengue virus infections in Vietnamese patients presenting to primary care facilities with acute undifferentiated fever

Khoa T D Thai et al. J Infect. 2010 Mar.

Abstract

Objectives: To explore clinical and virological characteristics and describe the epidemiology of dengue in patients who presented with acute undifferentiated fever (AUF) at primary health centers (PHC) in Binh Thuan Province, Vietnam.

Methods: A prospective observational study was conducted from 2001 to 2006 to study the aetiology in AUF patients. Demographic and clinical information was obtained, and dengue polymerase chain reaction (RT-PCR) and serology were performed on a random selection of patients.

Results: Three hundred fifty-one serologically confirmed dengue patients including 68 primary and 283 secondary infections were included in this study. In 25% (86/351) dengue virus (DENV) was detected by RT-PCR among which 32 DENV-1, 16 DENV-2, 1 DENV-3 and 37 DENV-4 were identified. The predominant dengue serotype varied by year with seasonal fluctuation: DENV-4 in 2001-2002, DENV-1 and DENV-2 from 2003 to 2006. Primary dengue was more common in children. Higher viraemia levels (P=0.010) were found in primary infections compared to secondary infections. DENV-1 infected patients had higher viraemia levels than DENV-2 (P=0.003) and DENV-4 (P<0.001) infected patients. Clinical symptoms were often seen in adults. Few differences in clinical symptoms were found between primary and secondary infection and no significant differences in clinical symptoms between the serotypes were observed.

Conclusions: Our data provide insight in the epidemiology, clinical profile and virological features of mild symptomatic dengue patients who presented to PHC with AUF in Vietnam.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Co-occurrence of multiple dengue virus serotypes in Binh Thuan from 2001 to 2006.
Figure 2
Figure 2
Age group distribution of serologically (n = 1938) and RT-PCR (n = 86) confirmed dengue virus infection and serotypes among AUF patients in Binh Thuan province, 2001–2006.
Figure 3
Figure 3
Distribution of viraemia levels in: (A) patients with primary and secondary dengue infections; (B) patients with primary and secondary dengue infection and fever history; (C) patients with DENV-1, DENV-2, DENV-3 and DENV-4 infections; (D) patients with and without NS1 antigen. All comparison within groups was performed using Mann–Whitney tests. Box plots show median values (horizontal line in the box), 25–75% interquartile range (lower-upper limits of the box), 90% range of data (additional bars), and outliers (circles).
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. World Health Organization . 2nd ed. WHO; Geneva: 1997. Dengue haemorrhagic fever. Diagnosis, treatment and control.
    1. Gubler D.J. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002 Feb;10(2):100–103. - PubMed
    1. Beatty M., Letson W., Edgil D., Margolis H. Estimating the total world population at risk for locally acquired dengue infection. Abstract presented at the 56th Annual Meeting of the American Society of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2007;77(Suppl. 5):170–257. - PubMed
    1. Black W.C., Bennett K.E., Gorrochotegui-Escalante N., Barillas-Mury C.V., Fernandez-Salas I., de Lourdes M.M. Flavivirus susceptibility in Aedes aegypti. Arch Med Res. 2002 Jul;33(4):379–388. - PubMed
    1. Rigau-Perez J.G., Clark G.G., Gubler D.J., Reiter P., Sanders E.J., Vorndam A.V. Dengue and dengue haemorrhagic fever. Lancet. 1998 Sep 19;352(9132):971–977. - PubMed

Publication types

MeSH terms

-