Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Oct;11(10):700-14.
doi: 10.1038/nrm2970. Epub 2010 Sep 8.

Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter Vandenabeele  1 , Lorenzo Galluzzi, Tom Vanden Berghe, Guido Kroemer
Affiliations
Review

Molecular mechanisms of necroptosis: an ordered cellular explosion

Peter Vandenabeele et al. Nat Rev Mol Cell Biol. 2010 Oct.

Abstract

For a long time, apoptosis was considered the sole form of programmed cell death during development, homeostasis and disease, whereas necrosis was regarded as an unregulated and uncontrollable process. Evidence now reveals that necrosis can also occur in a regulated manner. The initiation of programmed necrosis, 'necroptosis', by death receptors (such as tumour necrosis factor receptor 1) requires the kinase activity of receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3), and its execution involves the active disintegration of mitochondrial, lysosomal and plasma membranes. Necroptosis participates in the pathogenesis of diseases, including ischaemic injury, neurodegeneration and viral infection, thereby representing an attractive target for the avoidance of unwarranted cell death.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Science. 2000 Jun 30;288(5475):2351-4 - PubMed
    1. J Gen Virol. 2003 Dec;84(Pt 12):3305-3314 - PubMed
    1. Sci STKE. 2006 Oct 24;2006(358):pe44 - PubMed
    1. Cell. 2005 Jan 28;120(2):275-85 - PubMed
    1. Cell Host Microbe. 2010 Apr 22;7(4):302-313 - PubMed

Publication types

Substances

LinkOut - more resources

-