Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration
- PMID: 28330582
- PMCID: PMC5459794
- DOI: 10.1016/j.stem.2017.02.009
Adipocyte Accumulation in the Bone Marrow during Obesity and Aging Impairs Stem Cell-Based Hematopoietic and Bone Regeneration
Abstract
Aging and obesity induce ectopic adipocyte accumulation in bone marrow cavities. This process is thought to impair osteogenic and hematopoietic regeneration. Here we specify the cellular identities of the adipogenic and osteogenic lineages of the bone. While aging impairs the osteogenic lineage, high-fat diet feeding activates expansion of the adipogenic lineage, an effect that is significantly enhanced in aged animals. We further describe a mesenchymal sub-population with stem cell-like characteristics that gives rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche by promoting competitive repopulation following lethal irradiation. Conversely, bone-resident cells committed to the adipocytic lineage inhibit hematopoiesis and bone healing, potentially by producing excessive amounts of Dipeptidyl peptidase-4, a protease that is a target of diabetes therapies. These studies delineate the molecular identity of the bone-resident adipocytic lineage, and they establish its involvement in age-dependent dysfunction of bone and hematopoietic regeneration.
Keywords: DPP4; adipogenesis; adipogenic progenitors; aging; bone healing; bone marrow adipose tissue; hematopoiesis; mesenchymal stem cells; obesity; regeneration.
Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.
Figures
![None](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/fx1.gif)
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/gr1.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/gr2.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/gr3.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/gr4.gif)
![Figure 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/gr5.gif)
![Figure 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/gr6.gif)
![Figure 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/5459794/bin/gr7.gif)
Comment in
-
Adipocytes at the Core of Bone Function.Cell Stem Cell. 2017 Jun 1;20(6):739-740. doi: 10.1016/j.stem.2017.05.008. Cell Stem Cell. 2017. PMID: 28575686
Similar articles
-
Dpp4+ interstitial progenitor cells contribute to basal and high fat diet-induced adipogenesis.Mol Metab. 2021 Dec;54:101357. doi: 10.1016/j.molmet.2021.101357. Epub 2021 Oct 15. Mol Metab. 2021. PMID: 34662714 Free PMC article.
-
Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation.Sci Rep. 2015 Aug 5;5:12348. doi: 10.1038/srep12348. Sci Rep. 2015. PMID: 26242871 Free PMC article.
-
Bone marrow adipose cells - cellular interactions and changes with obesity.J Cell Sci. 2020 Mar 6;133(5):jcs238394. doi: 10.1242/jcs.238394. J Cell Sci. 2020. PMID: 32144195 Review.
-
Identification of a mesenchymal progenitor cell hierarchy in adipose tissue.Science. 2019 Apr 26;364(6438):eaav2501. doi: 10.1126/science.aav2501. Science. 2019. PMID: 31023895 Free PMC article.
-
Bone Marrow Adipose Tissue: Regulation of Osteoblastic Niche, Hematopoiesis and Hematological Malignancies.Stem Cell Rev Rep. 2023 Jul;19(5):1135-1151. doi: 10.1007/s12015-023-10531-3. Epub 2023 Mar 17. Stem Cell Rev Rep. 2023. PMID: 36930385 Review.
Cited by
-
In Vitro Cell Surface Marker Expression on Mesenchymal Stem Cell Cultures does not Reflect Their Ex Vivo Phenotype.Stem Cell Rev Rep. 2024 Jun 5. doi: 10.1007/s12015-024-10743-1. Online ahead of print. Stem Cell Rev Rep. 2024. PMID: 38837115
-
Impact of body mass index on fracture severity, clinical, radiological and functional outcome in distal radius fractures: a retrospective observational study after surgical treatment.Arch Orthop Trauma Surg. 2024 Jun;144(6):2915-2923. doi: 10.1007/s00402-024-05391-6. Epub 2024 May 30. Arch Orthop Trauma Surg. 2024. PMID: 38814456 Free PMC article.
-
Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis.Biomedicines. 2024 May 13;12(5):1075. doi: 10.3390/biomedicines12051075. Biomedicines. 2024. PMID: 38791037 Free PMC article. Review.
-
Adipose tissue as a linchpin of organismal ageing.Nat Metab. 2024 May;6(5):793-807. doi: 10.1038/s42255-024-01046-3. Epub 2024 May 23. Nat Metab. 2024. PMID: 38783156 Review.
-
Bone Marrow Adipose Tissue.Cells. 2024 Apr 23;13(9):724. doi: 10.3390/cells13090724. Cells. 2024. PMID: 38727260 Free PMC article. Review.
References
-
- Carnevale V., Romagnoli E., D’Erasmo L., D’Erasmo E. Bone damage in type 2 diabetes mellitus. Nutr. Metab. Cardiovasc. Dis. 2014;24:1151–1157. - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
Miscellaneous