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Review

Imipramine

No authors listed
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
.
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Review

Imipramine

No authors listed.
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Excerpt

Milk levels of imipramine and its metabolite are low and have not been detected in the serum of breastfed infants. Immediate side effects have not been reported and a limited amount of follow-up has found no adverse effects on infant growth and development. Imipramine use during breastfeeding would usually not be expected to cause any adverse effects in breastfed infants, especially if the infant is older than 2 months. A safety scoring system finds imipramine use to be possible during breastfeeding.[1] Some experts consider imipramine one of the antidepressants of choice for nursing mothers.[2] However, other agents may be preferred when large doses are required or while nursing a newborn or preterm infant.

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References

    1. Uguz F. A new safety scoring system for the use of psychotropic drugs during lactation. Am J Ther. 2021;28:e118–e126. - PubMed
    1. Lanza di Scalea T, Wisner KL. Pharmacotherapy of postpartum depression. Expert Opin Pharmacother. 2009;10:2593–607. - PMC - PubMed
    1. Weissman AM, Levy BT, Hartz AJ, et al. Pooled analysis of antidepressant levels in lactating mothers, breast milk, and nursing infants. Am J Psychiatry. 2004;161:1066–78. - PubMed
    1. Ware MR, DeVane CL. Imipramine treatment of panic disorder during pregnancy. J Clin Psychiatry. 1990;51:482–4. - PubMed
    1. Sovner R, Orsulak PJ. Excretion of imipramine and desipramine in human breast milk. Am J Psychiatry. 1979;136:451–2. - PubMed

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