Bioavailability of Tea Catechins and Its Improvement

doi:10.3390/molecules23092346

Review

. 2018 Sep 13;23(9):2346.

doi: 10.3390/molecules23092346.

Bioavailability of Tea Catechins and Its Improvement

Zhuo-Yu Cai¹, Xu-Min Li², Jin-Pei Liang³, Li-Ping Xiang⁴, Kai-Rong Wang⁵, Yun-Long Shi⁶, Rui Yang⁷, Meng Shi⁸, Jian-Hui Ye⁹, Jian-Liang Lu¹⁰, Xin-Qiang Zheng¹¹, Yue-Rong Liang¹²

Affiliations

¹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21716160@zju.edu.cn.
² Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21616096@zju.edu.cn.
³ Intellectual Property Office of Lanshan District, Rizhao 543003, China. liangjinpeirz@163.com.
⁴ National Tea and Tea Product Quality Supervision and Inspection Center (Guizhou), Zunyi 563100, China. xlping6009@126.com.
⁵ Ningbo Extension Station of Forestry & Speciality Technology, Ningbo 315012, China. wkrtea321hjytea@163.com.
⁶ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 11516051@zju.edu.cn.
⁷ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21616106@zju.edu.cn.
⁸ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 11616052@zju.edu.cn.
⁹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. jianhuiye@zju.edu.cn.
¹⁰ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. jllu@zju.edu.cn.
¹¹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. xqzheng@zju.edu.cn.
¹² Tea Research Institute, Zhejiang University, Hangzhou 310058, China. yrliang@zju.edu.cn.

PMID: 30217074
PMCID: PMC6225109
DOI: 10.3390/molecules23092346

Review

Bioavailability of Tea Catechins and Its Improvement

Zhuo-Yu Cai et al. Molecules. 2018.

. 2018 Sep 13;23(9):2346.

doi: 10.3390/molecules23092346.

Authors

Zhuo-Yu Cai¹, Xu-Min Li², Jin-Pei Liang³, Li-Ping Xiang⁴, Kai-Rong Wang⁵, Yun-Long Shi⁶, Rui Yang⁷, Meng Shi⁸, Jian-Hui Ye⁹, Jian-Liang Lu¹⁰, Xin-Qiang Zheng¹¹, Yue-Rong Liang¹²

Affiliations

¹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21716160@zju.edu.cn.
² Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21616096@zju.edu.cn.
³ Intellectual Property Office of Lanshan District, Rizhao 543003, China. liangjinpeirz@163.com.
⁴ National Tea and Tea Product Quality Supervision and Inspection Center (Guizhou), Zunyi 563100, China. xlping6009@126.com.
⁵ Ningbo Extension Station of Forestry & Speciality Technology, Ningbo 315012, China. wkrtea321hjytea@163.com.
⁶ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 11516051@zju.edu.cn.
⁷ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 21616106@zju.edu.cn.
⁸ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. 11616052@zju.edu.cn.
⁹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. jianhuiye@zju.edu.cn.
¹⁰ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. jllu@zju.edu.cn.
¹¹ Tea Research Institute, Zhejiang University, Hangzhou 310058, China. xqzheng@zju.edu.cn.
¹² Tea Research Institute, Zhejiang University, Hangzhou 310058, China. yrliang@zju.edu.cn.

PMID: 30217074
PMCID: PMC6225109
DOI: 10.3390/molecules23092346

Abstract

Many in vitro studies have shown that tea catechins had vevarious health beneficial effects. However, inconsistent results between in vitro and in vivo studies or between laboratory tests and epidemical studies are observed. Low bioavailability of tea catechins was an important factor leading to these inconsistencies. Research advances in bioavailability studies involving absorption and metabolic biotransformation of tea catechins were reviewed in the present paper. Related techniques for improving their bioavailability such as nanostructure-based drug delivery system, molecular modification, and co-administration of catechins with other bioactives were also discussed.

Keywords: Camellia sinensis; bioavailability; catechins; interaction; nanoparticle.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Schematic diagram of metabolism of green tea catechins [28,32,33,37].

**Figure 2**
Molecular structures of (−)-epigallocatechin-3-gallate (EGCG) and EGCG-based prodrugs and analogs.

See this image and copyright information in PMC

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References

1. Nagle D.G., Ferreira D., Zhou Y.D. Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives. Phytochemistry. 2006;67:1849–1855. doi: 10.1016/j.phytochem.2006.06.020. - DOI - PMC - PubMed
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1. Miyazawa T. Absorption, metabolism and antioxidative effects of tea catechin in humans. Biofactors. 2000;13:55–59. doi: 10.1002/biof.5520130110. - DOI - PubMed
1. Fu Q.Y., Li Q.S., Lin X.M., Qiao R.Y., Yang R., Li X.M., Dong Z.B., Xiang L.P., Zheng X.Q., Lu J.L., et al. Antidiabetic effects of tea. Molecules. 2017;22:849. doi: 10.3390/molecules22050849. - DOI - PMC - PubMed
1. Cavet M.E., Harrington K.L., Vollmer T.R., Ward K.W., Zhang J.Z. Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells. Mol. Vis. 2011;17:533–542. - PMC - PubMed

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[1] Nagle D.G., Ferreira D., Zhou Y.D. Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives. Phytochemistry. 2006;67:1849–1855. doi: 10.1016/j.phytochem.2006.06.020. - DOI - PMC - PubMed

[2] Nagle D.G., Ferreira D., Zhou Y.D. Epigallocatechin-3-gallate (EGCG): Chemical and biomedical perspectives. Phytochemistry. 2006;67:1849–1855. doi: 10.1016/j.phytochem.2006.06.020. - DOI - PMC - PubMed

[3] Koch W., Kukula-Koch W., Komsta Ł., Marzec Z., Szwerc W., Głowniak K. Green tea quality evaluation based on its catechins and metals composition in combination with chemometric analysis. Molecules. 2018;23:1689. doi: 10.3390/molecules23071689. - DOI - PMC - PubMed

[4] Koch W., Kukula-Koch W., Komsta Ł., Marzec Z., Szwerc W., Głowniak K. Green tea quality evaluation based on its catechins and metals composition in combination with chemometric analysis. Molecules. 2018;23:1689. doi: 10.3390/molecules23071689. - DOI - PMC - PubMed

[5] Miyazawa T. Absorption, metabolism and antioxidative effects of tea catechin in humans. Biofactors. 2000;13:55–59. doi: 10.1002/biof.5520130110. - DOI - PubMed

[6] Miyazawa T. Absorption, metabolism and antioxidative effects of tea catechin in humans. Biofactors. 2000;13:55–59. doi: 10.1002/biof.5520130110. - DOI - PubMed

[7] Fu Q.Y., Li Q.S., Lin X.M., Qiao R.Y., Yang R., Li X.M., Dong Z.B., Xiang L.P., Zheng X.Q., Lu J.L., et al. Antidiabetic effects of tea. Molecules. 2017;22:849. doi: 10.3390/molecules22050849. - DOI - PMC - PubMed

[8] Fu Q.Y., Li Q.S., Lin X.M., Qiao R.Y., Yang R., Li X.M., Dong Z.B., Xiang L.P., Zheng X.Q., Lu J.L., et al. Antidiabetic effects of tea. Molecules. 2017;22:849. doi: 10.3390/molecules22050849. - DOI - PMC - PubMed

[9] Cavet M.E., Harrington K.L., Vollmer T.R., Ward K.W., Zhang J.Z. Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells. Mol. Vis. 2011;17:533–542. - PMC - PubMed

[10] Cavet M.E., Harrington K.L., Vollmer T.R., Ward K.W., Zhang J.Z. Anti-inflammatory and anti-oxidative effects of the green tea polyphenol epigallocatechin gallate in human corneal epithelial cells. Mol. Vis. 2011;17:533–542. - PMC - PubMed

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Bioavailability of Tea Catechins and Its Improvement

Affiliations

Bioavailability of Tea Catechins and Its Improvement

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