Effects of a 36-h Survival Training with Sleep Deprivation on Oxidative Stress and Muscle Damage Biomarkers in Young Healthy Men
- PMID: 30241324
- PMCID: PMC6211103
- DOI: 10.3390/ijerph15102066
Effects of a 36-h Survival Training with Sleep Deprivation on Oxidative Stress and Muscle Damage Biomarkers in Young Healthy Men
Abstract
The aim of this study was to analyze changes in oxidative stress and muscle damage markers during a 36-h survival training combined with sleep deprivation. The study included 23 male students of physical education (specialty: Physical Education for Uniformed Services), randomly divided into the survival or control group. The students in the survival group completed a 36-h survival training with moderate to low physical activity, without the possibility to sleep. The students in the control group performed only physical activity included in daily routines and had a normal sleep pattern. No significant changes in measured parameters were seen in the control group throughout the study period. In the survival group, plasma lipid hydroperoxides (LHs) and creatine kinase (CK) activity increased at 24 h and remained elevated up to 36 h (main effects for LHs: time, p = 0.006 and group × time, p = 0.00008; main effects for CK: time, p = 0.000001, group, p = 0.005, and group × time, p = 0.000001). A 12-h recovery was sufficient to normalize both LHs and CK to the pre-training level; in fact, the post-recovery LHs and CK levels were even lower than at baseline. Residual total antioxidant capacity (TAC) of plasma (without the major constituents: uric acid and albumin) was elevated at both 24 h and 36 h of survival training, but not following a 12-h recovery (main effects: group, p = 0.001 and group × time, p = 0.04). In turn, the activity of glutathione peroxidase (GPx) in whole blood and superoxide dismutase (SOD) in erythrocytes decreased between 24 h and 36 h of survival training (main group effect for GPx, p = 0.038 and SOD, p = 0.045). In conclusion, these findings imply that a 36-h survival training with sleep deprivation impairs enzymatic antioxidant defense, increases lipid peroxidation, and induces muscle damage. Our findings also indicate that at least in the case of young physically active men, a 12-h recovery after the 36-h period of physical activity with sleep deprivation may be sufficient for the normalization of oxidative and muscle damage markers and restoration of blood prooxidant-antioxidant homeostasis.
Keywords: Keywords: lipid peroxidation; antioxidant capacity; blood prooxidant-antioxidant homeostasis; creatine kinase activity; students of physical education.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
![Figure 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6211103/bin/ijerph-15-02066-g001.gif)
![Figure 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6211103/bin/ijerph-15-02066-g002.gif)
![Figure 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6211103/bin/ijerph-15-02066-g003.gif)
![Figure 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/6211103/bin/ijerph-15-02066-g004.gif)
Similar articles
-
Survival Training Effects on Oxidative Stress and Muscle Damage Biomarkers of Naval Cadets.Aerosp Med Hum Perform. 2020 Sep 1;91(9):720-724. doi: 10.3357/AMHP.5536.2020. Aerosp Med Hum Perform. 2020. PMID: 32867903
-
Assessment of the Levels of Oxidative Stress, Muscle Damage, and Psychomotor Abilities of Special Force Soldiers during Military Survival Training.Int J Environ Res Public Health. 2020 Jul 7;17(13):4886. doi: 10.3390/ijerph17134886. Int J Environ Res Public Health. 2020. PMID: 32645886 Free PMC article.
-
Submaximal exercise training, more than dietary selenium supplementation, improves antioxidant status and ameliorates exercise-induced oxidative damage to skeletal muscle in young equine athletes.J Anim Sci. 2017 Feb 1;95(2):657-670. doi: 10.2527/jas.2016.1130. J Anim Sci. 2017. PMID: 29432539 Clinical Trial.
-
Short-term high-intensity interval exercise training attenuates oxidative stress responses and improves antioxidant status in healthy humans.Food Chem Toxicol. 2013 Nov;61:171-7. doi: 10.1016/j.fct.2013.05.046. Epub 2013 Jun 6. Food Chem Toxicol. 2013. PMID: 23747717
-
Creatine kinase monitoring in sport medicine.Br Med Bull. 2007;81-82:209-30. doi: 10.1093/bmb/ldm014. Epub 2007 Jun 14. Br Med Bull. 2007. PMID: 17569697 Review.
Cited by
-
Thalamic neurometabolite alterations in chronic low back pain: a common phenomenon across musculoskeletal pain conditions?Pain. 2024 Jan 1;165(1):126-134. doi: 10.1097/j.pain.0000000000003002. Epub 2023 Aug 11. Pain. 2024. PMID: 37578456
-
Effects of sleep deprivation on coronary heart disease.Korean J Physiol Pharmacol. 2022 Sep 1;26(5):297-305. doi: 10.4196/kjpp.2022.26.5.297. Korean J Physiol Pharmacol. 2022. PMID: 36039730 Free PMC article. Review.
-
Sleep Duration and Hypertension: Epidemiological Evidence and Underlying Mechanisms.Am J Hypertens. 2022 Jan 5;35(1):3-11. doi: 10.1093/ajh/hpab146. Am J Hypertens. 2022. PMID: 34536276 Free PMC article. Review.
-
Anxiogenic Potential of Experimental Sleep Fragmentation Is Duration-Dependent and Mediated via Oxidative Stress State.Oxid Med Cell Longev. 2021 Aug 21;2021:2262913. doi: 10.1155/2021/2262913. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34471462 Free PMC article.
-
REM sleep loss-induced elevated noradrenaline could predispose an individual to psychosomatic disorders: a review focused on proposal for prediction, prevention, and personalized treatment.EPMA J. 2020 Aug 13;11(4):529-549. doi: 10.1007/s13167-020-00222-1. eCollection 2020 Dec. EPMA J. 2020. PMID: 33240449 Free PMC article. Review.
References
-
- Dąbrowski J., Ziemba A., Tomczak A., Mikulski T. Physical performance of healthy men exposed to long exercise and sleep deprivation. Medicina Sportiva. 2012;16:6–11.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials