New Advances in Adaptive Thermogenesis: UCP1 and Beyond
- PMID: 30503034
- DOI: 10.1016/j.cmet.2018.11.002
New Advances in Adaptive Thermogenesis: UCP1 and Beyond
Abstract
Brown and beige adipocytes can catabolize stored energy to generate heat, and this distinct capacity for thermogenesis could be leveraged as a therapy for metabolic diseases like obesity and type 2 diabetes. Thermogenic adipocytes drive heat production through close coordination of substrate supply with the mitochondrial oxidative machinery and effectors that control the rate of substrate oxidation. Together, this apparatus affords these adipocytes with tremendous capacity to drive thermogenesis. The best characterized thermogenic effector is uncoupling protein 1 (UCP1). Importantly, additional mechanisms for activating thermogenesis beyond UCP1 have been identified and characterized to varying extents. Acute regulation of these thermogenic pathways has been an active area of study, and numerous regulatory factors have been uncovered in recent years. Here we will review the evidence for regulators of heat production in thermogenic adipocytes in the context of the thermodynamic and kinetic principles that govern their therapeutic utility.
Keywords: UCP1; beige fat; brown fat; creatine; diabetes; mitochondria; obesity; redox metabolism; thermogenesis; uncoupling.
Copyright © 2018 Elsevier Inc. All rights reserved.
Similar articles
-
UCP1 Dependent and Independent Thermogenesis in Brown and Beige Adipocytes.Front Endocrinol (Lausanne). 2020 Jul 28;11:498. doi: 10.3389/fendo.2020.00498. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 32849287 Free PMC article. Review.
-
UCP1-independent thermogenesis.Biochem J. 2020 Feb 14;477(3):709-725. doi: 10.1042/BCJ20190463. Biochem J. 2020. PMID: 32059055 Review.
-
Mechanisms underlying UCP1 dependent and independent adipocyte thermogenesis.Obes Rev. 2019 Feb;20(2):241-251. doi: 10.1111/obr.12796. Epub 2018 Nov 18. Obes Rev. 2019. PMID: 30450758 Review.
-
Mitochondrial reactive oxygen species and adipose tissue thermogenesis: Bridging physiology and mechanisms.J Biol Chem. 2017 Oct 13;292(41):16810-16816. doi: 10.1074/jbc.R117.789628. Epub 2017 Aug 24. J Biol Chem. 2017. PMID: 28842500 Free PMC article. Review.
-
Brite/beige fat and UCP1 - is it thermogenesis?Biochim Biophys Acta. 2014 Jul;1837(7):1075-82. doi: 10.1016/j.bbabio.2014.02.008. Epub 2014 Feb 14. Biochim Biophys Acta. 2014. PMID: 24530356
Cited by
-
The Role of Exerkines in Obesity-Induced Disruption of Mitochondrial Homeostasis in Thermogenic Fat.Metabolites. 2024 May 17;14(5):287. doi: 10.3390/metabo14050287. Metabolites. 2024. PMID: 38786764 Free PMC article. Review.
-
Aging impairs cold-induced beige adipogenesis and adipocyte metabolic reprogramming.Elife. 2024 May 22;12:RP87756. doi: 10.7554/eLife.87756. Elife. 2024. PMID: 38775132 Free PMC article.
-
Coffee, tea, and cocoa in obesity prevention: Mechanisms of action and future prospects.Curr Res Food Sci. 2024 Apr 20;8:100741. doi: 10.1016/j.crfs.2024.100741. eCollection 2024. Curr Res Food Sci. 2024. PMID: 38694556 Free PMC article. Review.
-
Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway.Nutr Metab (Lond). 2024 Apr 24;21(1):22. doi: 10.1186/s12986-024-00790-3. Nutr Metab (Lond). 2024. PMID: 38658956 Free PMC article.
-
The molecular mechanism of macrophage-adipocyte crosstalk in maintaining energy homeostasis.Front Immunol. 2024 Apr 8;15:1378202. doi: 10.3389/fimmu.2024.1378202. eCollection 2024. Front Immunol. 2024. PMID: 38650945 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
