Arsenic exposure promotes the emergence of cardiovascular diseases
- PMID: 34253004
- DOI: 10.1515/reveh-2021-0004
Arsenic exposure promotes the emergence of cardiovascular diseases
Abstract
A large number of studies conducted in the past decade 2010-2020 refer to the impact of arsenic (As) exposure on cardiovascular risk factors. The arsenic effect on humans is complex and mainly depends on the varying individual susceptibilities, its numerous toxic expressions and the variation in arsenic metabolism between individuals. In this review we present relevant data from studies which document the association of arsenic exposure with various biomarkers, the effect of several genome polymorphisms on arsenic methylation and the underling molecular mechanisms influencing the cardiovascular pathology. The corresponding results provide strong evidence that high and moderate-high As intake induce oxidative stress, inflammation and vessel endothelial dysfunction that are associated with increased risk for cardiovascular diseases (CVDs) and in particular hypertension, myocardial infarction, carotid intima-media thickness and stroke, ventricular arrhythmias and peripheral arterial disease. In addition, As exposure during pregnancy implies risks for blood pressure abnormalities among infants and increased mortality rates from acute myocardial infarction during early adulthood. Low water As concentrations are associated with increased systolic, diastolic and pulse pressure, coronary heart disease and incident stroke. For very low As concentrations the relevant studies are few. They predict a risk for myocardial infarction, stroke and ischemic stroke and incident CVD, but they are not in agreement regarding the risk magnitude.
Keywords: arsenic exposure; cardiovascular disease; endothelial dysfunction; hypertension; peripheral arterial disease; prenatal exposure.
© 2021 Walter de Gruyter GmbH, Berlin/Boston.
Similar articles
-
Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh.Toxicol Appl Pharmacol. 2014 May 1;276(3):195-203. doi: 10.1016/j.taap.2014.02.014. Epub 2014 Mar 2. Toxicol Appl Pharmacol. 2014. PMID: 24593923 Free PMC article.
-
Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh.Am J Epidemiol. 2013 Aug 1;178(3):372-81. doi: 10.1093/aje/kwt001. Epub 2013 Jun 20. Am J Epidemiol. 2013. PMID: 23788675 Free PMC article.
-
Association of low-level arsenic exposure in drinking water with cardiovascular disease: a systematic review and risk assessment.Toxicology. 2014 Sep 2;323:78-94. doi: 10.1016/j.tox.2014.06.008. Epub 2014 Jun 20. Toxicology. 2014. PMID: 24953689 Review.
-
Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association.J Am Heart Assoc. 2023 Jul 4;12(13):e029852. doi: 10.1161/JAHA.123.029852. Epub 2023 Jun 12. J Am Heart Assoc. 2023. PMID: 37306302 Free PMC article.
-
Arsenic exposure and cardiovascular disease: an updated systematic review.Curr Atheroscler Rep. 2012 Dec;14(6):542-55. doi: 10.1007/s11883-012-0280-x. Curr Atheroscler Rep. 2012. PMID: 22968315 Free PMC article. Review.
Cited by
-
Assessing the Impact of PM2.5-Bound Arsenic on Cardiovascular Risk among Workers in a Non-ferrous Metal Smelting Area: Insights from Chemical Speciation and Bioavailability.Environ Sci Technol. 2024 May 14;58(19):8228-8238. doi: 10.1021/acs.est.3c10761. Epub 2024 May 2. Environ Sci Technol. 2024. PMID: 38695658 Free PMC article.
-
Update of the risk assessment of inorganic arsenic in food.EFSA J. 2024 Jan 18;22(1):e8488. doi: 10.2903/j.efsa.2024.8488. eCollection 2024 Jan. EFSA J. 2024. PMID: 38239496 Free PMC article.
-
Arsenic-Induced Ferroptosis in Chicken Hepatocytes via the Mitochondrial ROS Pathway.Biol Trace Elem Res. 2024 Sep;202(9):4180-4190. doi: 10.1007/s12011-023-03968-7. Epub 2023 Dec 16. Biol Trace Elem Res. 2024. PMID: 38102534
-
Research progress of different components of PM2.5 and ischemic stroke.Sci Rep. 2023 Sep 25;13(1):15965. doi: 10.1038/s41598-023-43119-5. Sci Rep. 2023. PMID: 37749193 Free PMC article. Review.
-
Non-Uniform Bioaccumulation of Lead and Arsenic in Two Remote Regions of the Human Heart's Left Ventricle: A Post-Mortem Study.Biomolecules. 2023 Aug 10;13(8):1232. doi: 10.3390/biom13081232. Biomolecules. 2023. PMID: 37627297 Free PMC article.
References
-
- Karagas, MR, Punshon, T, Davis, M, Bulka, CM, Francis Slaughter, F, Karalis, D, et al.. Rice intake and emerging concerns on arsenic in rice: a review of the human evidence and methodologic challenges. Curr Environ Health Rep 2019;6:361–72. https://doi.org/10.1007/s40572-019-00249-1.
-
- Argos, M, Kalra, T, Rathouz, PJ, Chen, Y, Pierce, B, Parvez, F, et al.. Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study. Lancet 2010;376:252–8. https://doi.org/10.1016/s0140-6736(10)60481-3.
-
- Ahmed, S, Ahsan, KB, Kippler, M, Mily, A, Wagatsuma, Y, Hoque, AMW, et al.. In utero arsenic exposure is associated with impaired thymic function in newborns possibly via oxidative stress and apoptosis. Toxicol Sci 2012;129:305–14. https://doi.org/10.1093/toxsci/kfs202.
-
- Abdul, KSM, Jayasinghe, SS, Chandana, EPS, Jayasumana, CP, De Silva, MCS. Arsenic and human health effects: a review. Environ Toxicol Pharmacol 2015;40:828–46. https://doi.org/10.1016/j.etap.2015.09.016.
-
- Awata, H, Linder, S, Mitchell, LE, Delclos, GL. Association of dietary intake and biomarker levels of arsenic, cadmium, lead, and mercury among Asian populations in the United States: NHANES 2011–2012. Environ Health Perspect 2017;125:314–23. https://doi.org/10.1289/ehp28.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous