Urinary Metals, Arsenic, and Polycyclic Aromatic Hydrocarbon Exposure and Risk of Self-reported Emphysema in the US Adult Population
- PMID: 35178625
- DOI: 10.1007/s00408-022-00518-1
Urinary Metals, Arsenic, and Polycyclic Aromatic Hydrocarbon Exposure and Risk of Self-reported Emphysema in the US Adult Population
Abstract
Purpose: Metal and chemical exposure can cause acute and chronic respiratory diseases in humans. The purpose of this analysis was to analyze 14 types of urinary metals including mercury, uranium, tin, lead, antimony, barium, cadmium, cobalt, cesium, molybdenum, manganese, strontium, thallium, tungsten, six types of speciated arsenic, total arsenic and seven forms of polycyclic aromatic hydrocarbons (PAHs), and the link with self-reported emphysema in the US adult population.
Methods: A cross-sectional analysis using the 2011-2012, 2013-2014 and 2015-2016 National Health and Nutrition Examination Survey datasets was conducted. A specialized weighted complex survey design analysis package was used in analyzing the data. Multivariate logistic regression models were used to assess the association between urinary metals, arsenic, and PAHs and self-reported emphysema among all participants and among non-smokers only. Models were adjusted for lifestyle and demographic factors.
Results: A total of 4,181 adults were analyzed. 1-Hydroxynaphthalene, 2-hydroxynaphthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxypyrene, and 2 & 3-hydroxyphenanthrene were positively associated with self-reported emphysema. Positive associations were also observed in cadmium and cesium with self-reported emphysema. Among non-smokers, quantiles among 2-hydroxynaphthalene, arsenocholine, total urinary arsenic, cesium, and tin were associated with increased odds of self-reported emphysema. Quantiles among 1-hydroxyphenanthrene, cadmium, manganese, lead, antimony, thallium, and tungsten were associated with an inverse relationship with self-reported emphysema in non-smokers.
Conclusion: The study determined that six types of urinary PAHs, cadmium, and cesium are positively associated with self-reported emphysema. Certain quantiles of 2-hydroxynaphthalene, arsenocholine, total urinary arsenic, cesium, and tin are positively associated with self-reported emphysema among non-smokers.
Keywords: Arsenic; Emphysema; Heavy metals; NHANES; Non-smoker; Polycyclic aromatic hydrocarbons.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Similar articles
-
Urinary metals, arsenic, and polycyclic aromatic hydrocarbon exposure and risk of chronic bronchitis in the US adult population.Environ Sci Pollut Res Int. 2022 Oct;29(48):73480-73491. doi: 10.1007/s11356-022-20982-9. Epub 2022 May 27. Environ Sci Pollut Res Int. 2022. PMID: 35624372
-
Urinary polycyclic aromatic hydrocarbon, arsenic, and metal exposure and correlation with emphysema in smokers.Toxicol Appl Pharmacol. 2022 Sep 1;450:116168. doi: 10.1016/j.taap.2022.116168. Epub 2022 Jul 13. Toxicol Appl Pharmacol. 2022. PMID: 35842137
-
Association between environmental toxic metals, arsenic and polycyclic aromatic hydrocarbons and chronic obstructive pulmonary disease in the US adult population.Environ Sci Pollut Res Int. 2022 Aug;29(36):54507-54517. doi: 10.1007/s11356-022-19695-w. Epub 2022 Mar 18. Environ Sci Pollut Res Int. 2022. PMID: 35303226
-
A State-of-the-Science Review on Metal Biomarkers.Curr Environ Health Rep. 2023 Sep;10(3):215-249. doi: 10.1007/s40572-023-00402-x. Epub 2023 Jun 20. Curr Environ Health Rep. 2023. PMID: 37337116 Free PMC article. Review.
-
Association of polycyclic aromatic hydrocarbons exposure with child neurodevelopment and adult emotional disorders: A meta-analysis study.Ecotoxicol Environ Saf. 2023 Apr 15;255:114770. doi: 10.1016/j.ecoenv.2023.114770. Epub 2023 Mar 15. Ecotoxicol Environ Saf. 2023. PMID: 36931089 Review.
Cited by
-
Oral arsenite exposure induces inflammation and apoptosis in pulmonary tissue: acute and chronic evaluation in young and adult mice.Biometals. 2024 Jun;37(3):587-607. doi: 10.1007/s10534-023-00577-8. Epub 2024 Jan 25. Biometals. 2024. PMID: 38267778
-
Systemic inflammation mediates environmental polycyclic aromatic hydrocarbons to increase chronic obstructive pulmonary disease risk in United States adults: a cross-sectional NHANES study.Front Public Health. 2023 Nov 21;11:1248812. doi: 10.3389/fpubh.2023.1248812. eCollection 2023. Front Public Health. 2023. PMID: 38074734 Free PMC article.
-
MicroRNAs as Potential Biomarkers of Environmental Exposure to Polycyclic Aromatic Hydrocarbons and Their Link with Inflammation and Lung Cancer.Int J Mol Sci. 2023 Nov 30;24(23):16984. doi: 10.3390/ijms242316984. Int J Mol Sci. 2023. PMID: 38069307 Free PMC article. Review.
-
LUNG Year in Review: 2022.Lung. 2023 Feb;201(1):1-4. doi: 10.1007/s00408-022-00594-3. Epub 2023 Jan 30. Lung. 2023. PMID: 36717405 Free PMC article. No abstract available.
References
-
- Global Initiative for Chronic Obstructive Lung Disease (2020) Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease 2021 report. https://goldcopd.org/wp-content/uploads/2020/11/GOLD-REPORT-2021-v1.1-25... . Accessed 25 Nov 2021
-
- Shapiro SD (2000) Animal models for chronic obstructive pulmonary diseases. Am J Respir Cell Mol Biol 22:4–7 - DOI
-
- GOLD (2018) Global strategy for the diagnosis, management and prevention of COPD, global initiative for chronic obstructive lung disease (GOLD) 2018. https://goldcopd.org/ . Accessed 25 Nov 2021
-
- Vogelmeier CF, Criner GJ, Martinez FJ et al (2017) Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med 195(5):557–582 - DOI
-
- Mirza S, Clay RD, Koslow MA, Scanlon PD (2018) COPD guidelines: a review of the 2018 GOLD report. Mayo Clin Proc 93(10):1488–1502. https://doi.org/10.1016/j.mayocp.2018.05.026 - DOI - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical