Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies
- PMID: 38378652
- PMCID: PMC10877904
- DOI: 10.1186/s13048-024-01369-5
Efficacy of natural products on premature ovarian failure: a systematic review and meta-analysis of preclinical studies
Abstract
Objective: This study aims to investigate the effects of natural products on animal models of premature ovarian failure (POF).
Methods: We conducted comprehensive literature searches and identified relevant studies that examined the protective effects of natural products on experimental POF. We extracted quantitative data on various aspects such as follicular development, ovarian function, physical indicators, oxidative stress markers, inflammatory factors, and protein changes. The data was analyzed using random-effects meta-analyses, calculating pooled standardized mean differences and 95% confidence intervals. Heterogeneity was assessed using the I2 statistic, and bias was estimated using the SYRCLE tool.
Results: Among the 879 reviewed records, 25 articles met our inclusion criteria. These findings demonstrate that treatment with different phytochemicals and marine natural products (flavonoids, phenols, peptides, and alkaloids, etc.) significantly improved various aspects of ovarian function compared to control groups. The treatment led to an increase in follicle count at different stages, elevated levels of key hormones, and a decrease in atretic follicles and hormone levels associated with POF. This therapy also reduced oxidative stress (specifically polyphenols, resveratrol) and apoptotic cell death (particularly flavonoids, chrysin) in ovarian granulosa cells, although it showed no significant impact on inflammatory responses. The certainty of evidence supporting these findings ranged from low to moderate.
Conclusions: Phytochemicals and marine natural product therapy (explicitly flavonoids, phenols, peptides, and alkaloids) has shown potential in enhancing folliculogenesis and improving ovarian function in animal models of POF. These findings provide promising strategies to protect ovarian reserve and reproductive health. Targeting oxidative stress and apoptosis pathways may be the underlying mechanism.
Keywords: Flavonoids; Oxidative stress; Phenols; Premature ovarian failure; Systematic review.
© 2024. The Author(s).
Conflict of interest statement
The authors declare no competing interests.
Figures
![Fig. 1](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig1_HTML.gif)
![Fig. 2](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig2_HTML.gif)
![Fig. 3](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig3_HTML.gif)
![Fig. 4](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig4_HTML.gif)
![Fig. 5](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig5_HTML.gif)
![Fig. 6](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig6_HTML.gif)
![Fig. 7](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig7_HTML.gif)
![Fig. 8](https://www.ncbi.nlm.nih.gov/pmc/articles/instance/10877904/bin/13048_2024_1369_Fig8_HTML.gif)
Similar articles
-
Natural products for treatment of premature ovarian failure: a narrative review.J Tradit Chin Med. 2023 Jun;43(3):606-617. doi: 10.19852/j.cnki.jtcm.20230227.002. J Tradit Chin Med. 2023. PMID: 37147765 Free PMC article. Review.
-
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217. Cochrane Database Syst Rev. 2022. PMID: 36321557 Free PMC article.
-
Chrysin reduces inflammation and oxidative stress and improves ovarian function in D-gal-induced premature ovarian failure.Bioengineered. 2022 Apr;13(4):8291-8301. doi: 10.1080/21655979.2021.2005991. Bioengineered. 2022. PMID: 35311454 Free PMC article.
-
Effects of hPMSCs on granulosa cell apoptosis and AMH expression and their role in the restoration of ovary function in premature ovarian failure mice.Stem Cell Res Ther. 2018 Jan 31;9(1):20. doi: 10.1186/s13287-017-0745-5. Stem Cell Res Ther. 2018. Retraction in: Stem Cell Res Ther. 2022 Oct 13;13(1):504. doi: 10.1186/s13287-022-03183-6. PMID: 29386068 Free PMC article. Retracted.
-
Immunoregulation of follicular renewal, selection, POF, and menopause in vivo, vs. neo-oogenesis in vitro, POF and ovarian infertility treatment, and a clinical trial.Reprod Biol Endocrinol. 2012 Nov 23;10:97. doi: 10.1186/1477-7827-10-97. Reprod Biol Endocrinol. 2012. PMID: 23176151 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
Grants and funding
- 2022-2-4097/Special Grant for Capital Health Research and Development
- 2020-2-40912/Special Grant for Capital Health Research and Development
- BYSYSZKF2023027/Funding from State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital
- 82074193/National Natural Science Foundation of China
- BYSYDL2022013/Cohort Construction Project of Peking University Third Hospital
LinkOut - more resources
Full Text Sources
Medical
Miscellaneous