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. 2024 May 21;24(1):385.
doi: 10.1186/s12888-024-05831-y.

Association among abnormal glycolipids, reproductive hormones, and cognitive dysfunction in female patients with bipolar disorder

Tianxiang Zou #  1 , Min Yang #  1 , Zhuohui Chen  2 , Haiqing Xie  3 , Jing Huang  1 , Yue Qin  1 , Furu Liu  1 , Haiyu Chen  1 , Xuelei Xu  1 , Jindong Chen  1 , Hui Tang  1 , Hui Xiang  1 , Haishan Wu  1 , MingHui Liu  3 , Wenbo Luo  3 , Jieyu Liu  4 , Ziwei Teng  5
Affiliations

Association among abnormal glycolipids, reproductive hormones, and cognitive dysfunction in female patients with bipolar disorder

Tianxiang Zou et al. BMC Psychiatry. .

Abstract

Background: Patients with bipolar disorder (BD) show abnormalities in glucolipid metabolism and reproductive hormone levels, which are of concern in women with BD. This study was dedicated to investigating the glucolipid and reproductive hormone levels of female patients, and to preliminarily investigating their relationships with cognition.

Methods: A total of 58 unmedicated female BD patients, 61 stable-medicated female BD patients, and 63 healthy controls (HC) were recruited in this study. Serum glycolipid indexes and reproductive hormones were measured. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and the Stroop Color-Word Test (Stroop test).

Results: Patients with BD showed significant cognitive impairment (p < 0.05), which was not affected by medication. Triglycerides (TG), luteinizing hormone (LH), and high-density lipoprotein cholesterol (HDL-c) were altered in stable-medicated BD patients. In addition, regression analysis showed that progesterone (PRGE) and prolactin (PRL) were negatively associated with cognitive performance in stable-medicated BD patients.

Conclusions: Female BD patients may have cognitive deficits and abnormal levels of glycolipids and reproductive hormones. And abnormal levels of glycolipids and reproductive hormones may be associated with cognitive dysfunction in female BD patients.

Keywords: Bipolar disorder; Cognitive dysfunction; Female; Glycolipid level; Reproductive hormone.

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Conflict of interest statement

The authors declare no competing interests.

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