Interaction of sulfpride and ergot derivatives on rat brain DOPAC concentration and prolactin secretion in vivo
- PMID: 467503
- DOI: 10.1016/0014-2999(79)90427-8
Interaction of sulfpride and ergot derivatives on rat brain DOPAC concentration and prolactin secretion in vivo
Abstract
Sulpiride, which differs from classical neuroleptics by not producing major extrapyramidal side effects, is a potent antiemetic agent and stimulates prolactin secretion in both laboratory animals and man. In parallel it increases dopamine synthesis in both striatum and nucleus accumbens. Bromocriptine and metergoline are two effective agents in suppressing prolactin release and postulated to stimulate dopamine receptors. The interactions of these two ergot derivatives with sulpiride have been investigated on prolactin release and on striatal and limbic DOPAC accumulation. Bromocriptine at all doses tested was able to suppress the increased in vivo prolactin secretion observed after sulpiride administration. Metergoline antagonized the sulpiride-induced prolactin increase only at low doses; on the contrary higher doses potentiated it. High concentrations of bromocriptine suppressed the sulpiride-induced increased of DOPAC levels in striatum and n. accumbens, while metergoline potentiated the sulpiride-induced accumulation of brain DOPAC.
Similar articles
-
The pharmacology of sulpiride--a dopamine receptor antagonist.Gen Pharmacol. 1982;13(3):185-93. doi: 10.1016/0306-3623(82)90088-x. Gen Pharmacol. 1982. PMID: 7047291 Review.
-
Does brain 3,4-dihydroxyphenylacetic acid reflect dopamine release?J Pharm Pharmacol. 1987 Feb;39(2):127-9. doi: 10.1111/j.2042-7158.1987.tb06958.x. J Pharm Pharmacol. 1987. PMID: 2881997
-
Ontogenetic changes in dopaminergic pre and postsynaptic elements in rat brain: effects of quinpirole and sulpiride.Neuropharmacology. 1991 May;30(5):531-4. doi: 10.1016/0028-3908(91)90017-6. Neuropharmacology. 1991. PMID: 1678147
-
Interaction of metergoline with striatal dopamine system.Life Sci. 1978 Dec 11;23(24):2383-91. doi: 10.1016/0024-3205(78)90296-5. Life Sci. 1978. PMID: 745518 No abstract available.
-
Stimulating action of sulpiride and pimozide on prolactin release. Effect on bromocriptine, L-dopa and metergoline administration.Acta Endocrinol (Copenh). 1977 Oct;86(2):251-6. doi: 10.1530/acta.0.0860251. Acta Endocrinol (Copenh). 1977. PMID: 578618
Cited by
-
Inhibition of cimetidine-induced hyperprolactinemia by pretreatment with metergoline.J Endocrinol Invest. 1981 Jan-Mar;4(1):111-3. doi: 10.1007/BF03349427. J Endocrinol Invest. 1981. PMID: 7240668 No abstract available.
-
Involvement of dopaminergic neurotransmission in the control of goal-directed movements.Psychopharmacology (Berl). 1983;80(4):360-4. doi: 10.1007/BF00432121. Psychopharmacology (Berl). 1983. PMID: 6312482
MeSH terms
Substances
LinkOut - more resources
Full Text Sources