Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
- PMID: 8080489
- DOI: 10.1161/01.cir.88.6.2510
Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus
Abstract
Background: Endothelium-dependent vasodilation is abnormal in experimental models of diabetes mellitus. We postulated that abnormalities of endothelial function are also present in patients with insulin-dependent diabetes mellitus and may contribute to the pathogenesis of vascular disease in these individuals.
Methods and results: Vascular reactivity was measured in the forearm resistance vessels of 15 patients with insulin-dependent diabetes mellitus and 16 age-matched normal subjects. No patient had hypertension or dyslipidemia. Each subject was pretreated with aspirin to inhibit endogenous production of prostanoids. Methacholine chloride (0.3 to 10 micrograms/min) was administered via the brachial artery to assess endothelium-dependent vasodilation. Sodium nitroprusside (0.3 to 10 micrograms/min) and verapamil (10 to 300 micrograms/min) were infused intra-arterially to assess endothelium-independent vasodilation; phenylephrine (0.3 to 3 micrograms/min) was administered to examine vasoconstrictor responsiveness. Forearm blood flow was determined by venous occlusion plethysmography, and dose-response curves were generated for each drug. Basal forearm blood flow in diabetic and normal subjects was comparable (2.6 +/- 0.2 versus 2.1 +/- 0.3 mL x 100 mL-1 x min-1, respectively; P = NS). The forearm vasodilative response to methacholine was less in diabetic than in normal subjects. At the highest dose of methacholine, the forearm blood flow increased 9.5 +/- 1.1 mL x 100 mL-1 x min-1 in diabetic subjects and 15.3 +/- 1.4 mL.100 mL-1 x min-1 in normal subjects (P < .01). The forearm blood flow responses to nitroprusside and verapamil and the forearm vasoconstrictor responses to phenylephrine were similar in diabetic and healthy subjects. In diabetic subjects, endothelium-dependent vasodilation correlated inversely with serum insulin concentration but not with glucose concentration, glycosylated hemoglobin, or duration of diabetes.
Conclusions: Endothelium-dependent vasodilation is abnormal in forearm resistance vessels of patients with insulin-dependent diabetes mellitus. This abnormality may be relevant to the high prevalence of vascular disease that occurs in these individuals.
Comment in
-
Time course of endothelial dysfunction in diabetes mellitus.Circulation. 1994 Aug;90(2):1109-10. doi: 10.1161/01.cir.90.2.1109. Circulation. 1994. PMID: 8044928 No abstract available.
Similar articles
-
Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus.J Am Coll Cardiol. 1996 Mar 1;27(3):567-74. doi: 10.1016/0735-1097(95)00522-6. J Am Coll Cardiol. 1996. PMID: 8606266
-
Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus.J Clin Invest. 1996 Jan 1;97(1):22-8. doi: 10.1172/JCI118394. J Clin Invest. 1996. PMID: 8550838 Free PMC article. Clinical Trial.
-
Vasodilator responses in the forearm skin of patients with insulin-dependent diabetes mellitus.Vasc Med. 1996;1(3):187-93. doi: 10.1177/1358863X9600100303. Vasc Med. 1996. PMID: 9546937
-
Nitric oxide and vascular reactivity in African American patients with hypertension.J Card Fail. 2003 Oct;9(5 Suppl Nitric Oxide):S199-204; discussion S205-9. doi: 10.1054/s1071-9164(03)00588-8. J Card Fail. 2003. PMID: 14583889 Review. No abstract available.
-
The vascular endothelium and human diseases.Int J Biol Sci. 2013 Nov 9;9(10):1057-69. doi: 10.7150/ijbs.7502. eCollection 2013. Int J Biol Sci. 2013. PMID: 24250251 Free PMC article. Review.
Cited by
-
Differences in endothelial function between patients with Type 1 and Type 2 diabetes: effects of red blood cells and arginase.Clin Sci (Lond). 2024 Aug 7;138(15):975-985. doi: 10.1042/CS20240447. Clin Sci (Lond). 2024. PMID: 39037711 Free PMC article.
-
Oxidative and Nitrous Stress Underlies Vascular Malfunction Induced by Ionizing Radiation and Diabetes.Cardiovasc Toxicol. 2024 Aug;24(8):776-788. doi: 10.1007/s12012-024-09878-x. Epub 2024 Jun 25. Cardiovasc Toxicol. 2024. PMID: 38916845 Review.
-
Long-Term Effects of Suramin on Renal Function in Streptozotocin-Induced Diabetes in Rats.Int J Mol Sci. 2023 Sep 28;24(19):14671. doi: 10.3390/ijms241914671. Int J Mol Sci. 2023. PMID: 37834118 Free PMC article.
-
Steady solution and its stability of a mathematical model of diabetic atherosclerosis.J Biol Dyn. 2023 Dec;17(1):2257734. doi: 10.1080/17513758.2023.2257734. J Biol Dyn. 2023. PMID: 37711027
-
Correlation of hemoglobin levels with diabetic retinopathy in US adults aged ≥40 years: the NHANES 2005-2008.Front Endocrinol (Lausanne). 2023 Aug 2;14:1195647. doi: 10.3389/fendo.2023.1195647. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37600684 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous