Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
- PMID: 8953045
- DOI: 10.1126/science.274.5295.2100
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
Abstract
Adipocyte differentiation is an important component of obesity and other metabolic diseases. This process is strongly inhibited by many mitogens and oncogenes. Several growth factors that inhibit fat cell differentiation caused mitogen-activated protein (MAP) kinase-mediated phosphorylation of the dominant adipogenic transcription factor peroxisome proliferator-activated receptor gamma (PPARgamma) and reduction of its transcriptional activity. Expression of PPARgamma with a nonphosphorylatable mutation at this site (serine-112) yielded cells with increased sensitivity to ligand-induced adipogenesis and resistance to inhibition of differentiation by mitogens. These results indicate that covalent modification of PPARgamma by serum and growth factors is a major regulator of the balance between cell growth and differentiation in the adipose cell lineage.
Similar articles
-
Genes and transcription factors, including nuclear receptors: methods of studying their interactions.J Lab Clin Med. 2002 Oct;140(4):215-27. doi: 10.1067/mlc.2002.127370. J Lab Clin Med. 2002. PMID: 12389019 Review. No abstract available.
-
c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity.Endocrinology. 1999 Jan;140(1):392-7. doi: 10.1210/endo.140.1.6457. Endocrinology. 1999. PMID: 9886850
-
Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis.J Biol Chem. 1998 Nov 27;273(48):32111-20. doi: 10.1074/jbc.273.48.32111. J Biol Chem. 1998. PMID: 9822687
-
Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase.J Biol Chem. 1997 Apr 18;272(16):10811-6. doi: 10.1074/jbc.272.16.10811. J Biol Chem. 1997. PMID: 9099735
-
Insulin- and mitogen-activated protein kinase-mediated phosphorylation and activation of peroxisome proliferator-activated receptor gamma.J Biol Chem. 1996 Dec 13;271(50):31771-4. doi: 10.1074/jbc.271.50.31771. J Biol Chem. 1996. PMID: 8943212
Cited by
-
Stellera chamaejasme L. extract inhibits adipocyte differentiation through activation of the extracellular signal-regulated kinase pathway.PLoS One. 2024 Mar 21;19(3):e0300520. doi: 10.1371/journal.pone.0300520. eCollection 2024. PLoS One. 2024. PMID: 38512891 Free PMC article.
-
Platelet-derived growth factor receptor beta is required for embryonic specification and confinement of the adult white adipose lineage.iScience. 2023 Dec 12;27(1):108682. doi: 10.1016/j.isci.2023.108682. eCollection 2024 Jan 19. iScience. 2023. PMID: 38235323 Free PMC article.
-
Ginsenoside Rg1 promotes β‑amyloid peptide degradation through inhibition of the ERK/PPARγ phosphorylation pathway in an Alzheimer's disease neuronal model.Exp Ther Med. 2023 Nov 23;27(1):31. doi: 10.3892/etm.2023.12319. eCollection 2024 Jan. Exp Ther Med. 2023. PMID: 38125359 Free PMC article.
-
Functional role of skeletal muscle-derived interleukin-6 and its effects on lipid metabolism.Front Physiol. 2023 Jul 24;14:1110926. doi: 10.3389/fphys.2023.1110926. eCollection 2023. Front Physiol. 2023. PMID: 37555019 Free PMC article. Review.
-
PPARγ Acetylation in Adipocytes Exacerbates BAT Whitening and Worsens Age-Associated Metabolic Dysfunction.Cells. 2023 May 18;12(10):1424. doi: 10.3390/cells12101424. Cells. 2023. PMID: 37408258 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Molecular Biology Databases