Relationship of anterior and posterior subcutaneous abdominal fat to insulin sensitivity in nondiabetic men
- PMID: 9112243
- DOI: 10.1002/j.1550-8528.1997.tb00648.x
Relationship of anterior and posterior subcutaneous abdominal fat to insulin sensitivity in nondiabetic men
Abstract
Recent studies from our reveal that adipose tissue (AT) in the subcutaneous abdominal region is the most important determinant of peripheral and hepatic insulin sensitivity. Because of different anatomic and physiologic characteristics of anterior and posterior subcutaneous abdominal AT, we investigated the relationship of the masses of each compartment, as determined by magnetic resonance imaging, to insulin sensitivity (using euglycemic hyperinsulinemic glucose clamp technique), and other anthropometric variables. Thirty-four healthy men with varying ranges of obesity were recruited for the study. The mass of posterior subcutaneous abdominal AT was approximately 1.6 times more than that of the anterior compartment, and these masses accounted for 12.9% and 8.2% of the total body fat mass, respectively. All anthropometric variables, including body mass index (BMI), waist-to-hip circumference ratio (WHR), skin-fold thicknesses, and intraperitoneal AT mass were more significantly related to the posterior than the anterior subcutaneous abdominal AT mass. Compared to the anterior compartment mass, the posterior compartment mass displayed stronger relationship with insulin-mediated glucose disposal (Rd) (r = -0.44, p = 0.009, and r = -0.76, p = 0.0001, respectively) as well as with residual hepatic glucose output during the 40 mU.m-2.min-1 insulin infusion (r = 0.39, p = 0.02, and r = 0.53, p = 0.001, respectively). After adjusting for total body fat, the Rd values showed a significant partial correlation with the posterior subcutaneous abdominal AT mass (r = 0.52, p = 0.002). To conclude, posterior subcutaneous abdominal AT mass is more important determinant of peripheral and hepatic insulin sensitivity than the anterior subcutaneous abdominal AT.
Similar articles
-
Relationships of generalized and regional adiposity to insulin sensitivity in men.J Clin Invest. 1995 Jul;96(1):88-98. doi: 10.1172/JCI118083. J Clin Invest. 1995. PMID: 7615840 Free PMC article.
-
Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM.Diabetes. 1996 Dec;45(12):1684-93. doi: 10.2337/diab.45.12.1684. Diabetes. 1996. PMID: 8922352
-
Body fat distribution in pre- and post-menopausal women: metabolic and anthropometric variables and their inter-relationships.Int J Obes Relat Metab Disord. 1992 Jul;16(7):495-504. Int J Obes Relat Metab Disord. 1992. PMID: 1323546
-
Waist circumference, waist-to-hip ratio and body mass index as predictors of adipose tissue compartments in men.QJM. 2003 Jun;96(6):441-7. doi: 10.1093/qjmed/hcg069. QJM. 2003. PMID: 12788963
-
Simple skinfold-thickness measurements complement conventional anthropometric assessments in predicting glucose tolerance.Am J Clin Nutr. 2001 Mar;73(3):567-73. doi: 10.1093/ajcn/73.3.567. Am J Clin Nutr. 2001. PMID: 11237933
Cited by
-
Unraveling White Adipose Tissue Heterogeneity and Obesity by Adipose Stem/Stromal Cell Biology and 3D Culture Models.Cells. 2023 Jun 8;12(12):1583. doi: 10.3390/cells12121583. Cells. 2023. PMID: 37371053 Free PMC article. Review.
-
Ciliary control of adipocyte progenitor cell fate regulates energy storage.Front Cell Dev Biol. 2022 Dec 6;10:1083372. doi: 10.3389/fcell.2022.1083372. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36561368 Free PMC article. Review.
-
Chromatin accessibility landscape of stromal subpopulations reveals distinct metabolic and inflammatory features of porcine subcutaneous and visceral adipose tissue.PeerJ. 2022 May 24;10:e13250. doi: 10.7717/peerj.13250. eCollection 2022. PeerJ. 2022. PMID: 35646489 Free PMC article.
-
Magnetic resonance imaging-based body composition is associated with nutritional and inflammatory status: a longitudinal study in patients with Crohn's disease.Insights Imaging. 2021 Dec 4;12(1):178. doi: 10.1186/s13244-021-01121-3. Insights Imaging. 2021. PMID: 34862942 Free PMC article.
-
Creatine Monohydrate Supplementation Increases White Adipose Tissue Mitochondrial Markers in Male and Female Rats in a Depot Specific Manner.Nutrients. 2021 Jul 14;13(7):2406. doi: 10.3390/nu13072406. Nutrients. 2021. PMID: 34371916 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous