Ednra (endothelin receptor type A) - Rat Genome Database

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Gene: Ednra (endothelin receptor type A) Rattus norvegicus
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Symbol: Ednra
Name: endothelin receptor type A
RGD ID: 2535
Description: Enables endothelin receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cellular response to mechanical stimulus; and glomerular filtration. Located in T-tubule and nuclear membrane. Used to study hypertension; myocardial infarction; portal hypertension; pulmonary emphysema; and pulmonary hypertension. Biomarker of several diseases, including hyperhomocysteinemia; impotence; obstructive sleep apnea; renal fibrosis; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypertension (multiple); lung disease; mandibulofacial dysostosis with alopecia; migraine; and obstructive sleep apnea. Orthologous to human EDNRA (endothelin receptor type A); PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (R)-noradrenaline; 11-deoxycorticosterone; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ENDOR; endothelin A receptor; endothelin-1 receptor; endothelin-1 receptor-like; ET-A; ET-AR; Eta; LOC100366209; RATENDOR; RGD1559432
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Scl12  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,137,360 - 47,207,961 (+)NCBIGRCr8mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2 EnsemblUTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIRnor_SHRUTH_Rnor_SHR_UtxUTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4RGSC_v3.11932,051,058 - 32,110,066 (+)NCBICelera1929,719,589 - 29,778,843 (+)NCBICeleraCytogenetic Map19q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
EdnraRatAcute Experimental Pancreatitis treatmentIMP 1581841 RGD 
EdnraRatasthma  ISOEdnra (Mus musculus)4892322 RGD 
EdnraRatasthma  ISOEdnra (Mus musculus)4892288 RGD 
EdnraRatCardiovascular Abnormalities  ISOEdnra (Mus musculus)734910 RGD 
EdnraRatDiabetic Nephropathies  IMP 4892326associated with Diabetes Mellitus and ExperimentalRGD 
EdnraRatExperimental Diabetes Mellitus  IMP 4892336 RGD 
EdnraRathyperhomocysteinemia  IEP 4892572 RGD 
EdnraRathypertension  ISOEDNRA (Homo sapiens)1580950 RGD 
EdnraRathypertension  IDA 1581830 RGD 
EdnraRathypertension  IEP 4892284associated with UremiaRGD 
EdnraRatimpotence  IEP 2292142 RGD 
EdnraRatInflammation  ISOEdnra (Mus musculus)4892288 RGD 
EdnraRatlung disease severityISOEDNRA (Homo sapiens)4892286associated with Cystic FibrosisRGD 
EdnraRatmigraine  ISOEDNRA (Homo sapiens)734916DNA:polymorphism:-231A>GRGD 
EdnraRatmyocardial infarction  IDA 1580948 RGD 
EdnraRatMyocardial Ischemia  ISOEDNRA (Homo sapiens)1580946 RGD 
EdnraRatMyocardial Reperfusion Injury  IMP 4892580 RGD 
EdnraRatNeoplasm Metastasis  ISOEdnra (Mus musculus)4892282associated with Bladder NeoplasmsRGD 
EdnraRatnephrotic syndrome  IEP 7244242mRNA:increased expression:GlomerulusRGD 
EdnraRatobstructive sleep apnea  IEP 4145067 RGD 
EdnraRatobstructive sleep apnea  ISOEDNRA (Homo sapiens)4892306DNA:polymorphism: :-231G>A (human)RGD 
EdnraRatOptic Nerve Injuries  IEP 4892579mRNA:increased expression:retinaRGD 
EdnraRatpleurisy  ISOEdnra (Mus musculus)4892325 RGD 
EdnraRatportal hypertension  IMP 4892595 RGD 
EdnraRatpulmonary emphysema  IMP 4892307 RGD 
EdnraRatpulmonary hypertension  IMP 4892283 RGD 
EdnraRatpulmonary hypertension  IDA 1580949 RGD 
EdnraRatpulmonary hypertension  ISOEDNRA (Homo sapiens)4144877 RGD 
EdnraRatpulmonary hypertension  ISOEDNRA (Homo sapiens)4892320 RGD 
EdnraRatrenal fibrosis  IEP 7244179associated with Ureteral obstruction and mRNA:increased expression:kidney RGD 
EdnraRatStroke  IMP 4892584 RGD 
EdnraRattype 2 diabetes mellitus  IEP 2313280protein:increased expression:mesenteric arteryRGD 

Imported Disease Annotations - ClinVar

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
EdnraRatgenetic disease  ISOEDNRA (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
EdnraRatmandibulofacial dysostosis with alopecia  ISOEDNRA (Homo sapiens)8554872ClinVar Annotator: match by term: Mandibulofacial dysostosis with alopeciaClinVarPMID:16116593 more ...
EdnraRatmethylmalonic acidemia cblA type  ISOEDNRA (Homo sapiens)8554872ClinVar Annotator: match by term: Methylmalonic aciduria and cblA typeClinVarPMID:15523652 more ...
EdnraRatmigraine  ISOEDNRA (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11376172 more ...

Imported Disease Annotations - CTD

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatcongenital heart disease  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9811577EdnraRatcongestive heart failure  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28095452EdnraRatCraniofacial Abnormalities  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9811577 and PMID:17294360EdnraRatDiaphragmatic Hernia  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9473106 and PMID:10693666EdnraRatDisease Progression  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25194819EdnraRathypertension  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12600921EdnraRatimpotence  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18823320EdnraRatNasopharyngeal Neoplasms  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17032313EdnraRatobstructive sleep apnea  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20083432EdnraRatOvarian Neoplasms  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25194819EdnraRatStroke  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29531354EdnraRattype 2 diabetes mellitus  ISOEDNRA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16387788

Imported Disease Annotations - MGI

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatmandibulofacial dysostosis with alopecia  ISSEdnra (Mus musculus)13592920OMIM:616367MouseDO EdnraRatvelocardiofacial syndrome  ISSEdnra (Mus musculus)13592920OMIM:192430MouseDO 

Imported Disease Annotations - OMIM

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatmandibulofacial dysostosis with alopecia  ISOEDNRA (Homo sapiens)7240710 OMIM EdnraRatmigraine  ISOEDNRA (Homo sapiens)7240710 OMIM 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRat(R)-noradrenaline multiple interactionsEXP 6480464[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to NorepinephrineCTDPMID:15834289EdnraRat(S)-nicotine decreases expressionISOEDNRA (Homo sapiens)6480464Nicotine results in decreased expression of EDNRA mRNACTDPMID:18247414EdnraRat1,2-dimethylhydrazine multiple interactionsISOEdnra (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EDNRA mRNACTDPMID:22206623EdnraRat1,2-dimethylhydrazine increases expressionISOEdnra (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of EDNRA mRNACTDPMID:22206623EdnraRat11-deoxycorticosterone multiple interactionsEXP 6480464[5-(dimethylamino)-N-(3 more ...CTDPMID:16271043 and PMID:22431579EdnraRat11-deoxycorticosterone affects response to substanceEXP 6480464EDNRA protein affects the susceptibility to DesoxycorticosteroneCTDPMID:12600921EdnraRat17beta-estradiol increases expressionISOEDNRA (Homo sapiens)6480464Estradiol results in increased expression of EDNRA mRNACTDPMID:19943105EdnraRat17beta-estradiol multiple interactionsISOEDNRA (Homo sapiens)6480464Tamoxifen inhibits the reaction [Estradiol results in increased expression of EDNRA mRNA]CTDPMID:19943105EdnraRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:27291303EdnraRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOEdnra (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of EDNRA mRNACTDPMID:25975270EdnraRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of EDNRA mRNACTDPMID:34747641EdnraRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of EDNRA mRNACTDPMID:32109520EdnraRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOEdnra (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of EDNRA mRNACTDPMID:26290441EdnraRat2-naphthylamine decreases expressionISOEDNRA (Homo sapiens)64804642-Naphthylamine results in decreased expression of EDNRA mRNACTDPMID:18247414EdnraRat3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine increases expressionEXP 6480464Puromycin Aminonucleoside results in increased expression of EDNRA mRNACTDPMID:12972712EdnraRat4,4'-sulfonyldiphenol increases expressionISOEdnra (Mus musculus)6480464bisphenol S results in increased expression of EDNRA mRNACTDPMID:30951980EdnraRat4,4'-sulfonyldiphenol decreases methylationISOEDNRA (Homo sapiens)6480464bisphenol S results in decreased methylation of EDNRA geneCTDPMID:31601247EdnraRat5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide multiple interactionsEXP 6480464[5-(dimethylamino)-N-(3 more ...CTDPMID:16271043EdnraRat5-fluorouracil affects response to substanceISOEDNRA (Homo sapiens)6480464EDNRA protein affects the susceptibility to FluorouracilCTDPMID:17032313EdnraRat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of EDNRA mRNACTDPMID:24780913 and PMID:25825206EdnraRatacadesine multiple interactionsEXP 6480464acadesine inhibits the reaction [Smoke results in increased expression of EDNRA protein]CTDPMID:36183783EdnraRatacetamide increases expressionEXP 6480464acetamide results in increased expression of EDNRA mRNACTDPMID:31881176EdnraRatacrolein multiple interactionsISOEDNRA (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EDNRA mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of EDNRA mRNACTDPMID:32699268EdnraRatactinomycin D multiple interactionsEXP 6480464[Dimethyl Sulfoxide co-treated with Dactinomycin] results in decreased expression of EDNRA mRNA more ...CTDPMID:20561571EdnraRataflatoxin B1 decreases methylationISOEDNRA (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of EDNRA geneCTDPMID:27153756EdnraRataflatoxin B1 increases expressionISOEDNRA (Homo sapiens)6480464Aflatoxin B1 results in increased expression of EDNRA mRNACTDPMID:32234424EdnraRataflatoxin B1 increases methylationISOEDNRA (Homo sapiens)6480464Aflatoxin B1 results in increased methylation of EDNRA exonCTDPMID:30157460EdnraRatAflatoxin B2 alpha increases methylationISOEDNRA (Homo sapiens)6480464aflatoxin B2 results in increased methylation of EDNRA exon and aflatoxin B2 results in increased methylation of EDNRA intronCTDPMID:30157460EdnraRatagmatine multiple interactionsISOEDNRA (Homo sapiens)6480464Agmatine inhibits the reaction [Palmitic Acid results in decreased expression of EDNRA protein]CTDPMID:35747990EdnraRataldehydo-D-glucose increases expressionISOEDNRA (Homo sapiens)6480464Glucose results in increased expression of EDNRA mRNACTDPMID:31655124EdnraRataldosterone multiple interactionsEXP 6480464[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Aldosterone results in increased expression of IL18 mRNA] and [EDN1 protein binds to and results in increased activity of EDNRA protein] promotes the reaction [Aldosterone results in increased expression of IL18 mRNA]CTDPMID:18660453EdnraRatall-trans-retinoic acid increases expressionISOEDNRA (Homo sapiens)6480464Tretinoin results in increased expression of EDNRA mRNACTDPMID:21934132EdnraRatall-trans-retinoic acid multiple interactionsISOEdnra (Mus musculus)6480464[bisphenol A co-treated with Tretinoin] results in decreased expression of EDNRA mRNACTDPMID:30951980EdnraRatall-trans-retinoic acid decreases expressionISOEDNRA (Homo sapiens)6480464Tretinoin results in decreased expression of EDNRA mRNACTDPMID:23724009EdnraRatalpha-pinene multiple interactionsISOEDNRA (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EDNRA mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of EDNRA mRNACTDPMID:32699268EdnraRatambrisentan multiple interactionsISOEDNRA (Homo sapiens)6480464ambrisentan binds to and results in decreased activity of EDNRA proteinCTDPMID:16219361EdnraRataminoguanidine multiple interactionsEXP 6480464pimagedine inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA]CTDPMID:18594475EdnraRatamitrole increases expressionEXP 6480464Amitrole results in increased expression of EDNRA mRNACTDPMID:30047161EdnraRatanthra[1,9-cd]pyrazol-6(2H)-one multiple interactionsEXP 6480464pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA mRNA] and pyrazolanthrone inhibits the reaction [Particulate Matter results in increased expression of EDNRA protein]CTDPMID:20561571EdnraRatantirheumatic drug increases expressionISOEDNRA (Homo sapiens)6480464Antirheumatic Agents results in increased expression of EDNRA mRNACTDPMID:24449571EdnraRatapocynin multiple interactionsEXP 6480464acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA] and acetovanillone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]CTDPMID:23270704EdnraRatarsane affects expressionISOEdnra (Mus musculus)6480464Arsenic affects the expression of EDNRA mRNACTDPMID:19654921EdnraRatarsenic atom affects expressionISOEdnra (Mus musculus)6480464Arsenic affects the expression of EDNRA mRNACTDPMID:19654921EdnraRataspartame decreases expressionISOEDNRA (Homo sapiens)6480464Aspartame results in decreased expression of EDNRA mRNACTDPMID:31655124EdnraRatatorvastatin calcium multiple interactionsEXP 6480464Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA] and Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA]CTDPMID:23091284EdnraRatatorvastatin calcium decreases expressionEXP 6480464Atorvastatin results in decreased expression of EDNRA mRNACTDPMID:23091284EdnraRatatrasentan multiple interactionsISOEdnra (Mus musculus)6480464atrasentan binds to and results in decreased activity of EDNRA proteinCTDPMID:18516094EdnraRatatrasentan multiple interactionsEXP 6480464Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of EDNRA mRNA]CTDPMID:34102242EdnraRatatrasentan multiple interactionsISOEDNRA (Homo sapiens)6480464atrasentan binds to and results in decreased activity of EDNRA proteinCTDPMID:12193141 more ...EdnraRatatrazine decreases expressionEXP 6480464Atrazine results in decreased expression of EDNRA mRNACTDPMID:36841081EdnraRatbelinostat increases expressionISOEDNRA (Homo sapiens)6480464belinostat results in increased expression of EDNRA mRNACTDPMID:26272509EdnraRatbelinostat multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNACTDPMID:27188386EdnraRatbenzo[a]pyrene decreases expressionISOEDNRA (Homo sapiens)6480464Benzo(a)pyrene results in decreased expression of EDNRA mRNACTDPMID:18247414EdnraRatbenzo[a]pyrene increases methylationISOEDNRA (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of EDNRA promoterCTDPMID:27901495EdnraRatbenzo[a]pyrene decreases expressionISOEdnra (Mus musculus)6480464Benzo(a)pyrene results in decreased expression of EDNRA mRNACTDPMID:22228805EdnraRatbis(2-ethylhexyl) phthalate increases expressionEXP 6480464Diethylhexyl Phthalate results in increased expression of EDNRA mRNACTDPMID:20920545EdnraRatbis(2-ethylhexyl) phthalate decreases expressionISOEDNRA (Homo sapiens)6480464Diethylhexyl Phthalate results in decreased expression of EDNRA mRNACTDPMID:31163220EdnraRatbisphenol A increases expressionISOEdnra (Mus musculus)6480464bisphenol A results in increased expression of EDNRA mRNACTDPMID:26063408 and PMID:30951980EdnraRatbisphenol A decreases expressionISOEdnra (Mus musculus)6480464bisphenol A results in decreased expression of EDNRA mRNACTDPMID:32156529EdnraRatbisphenol A multiple interactionsISOEdnra (Mus musculus)6480464[bisphenol A co-treated with Tretinoin] results in decreased expression of EDNRA mRNACTDPMID:30951980EdnraRatbisphenol A affects expressionEXP 6480464bisphenol A affects the expression of EDNRA mRNACTDPMID:25181051EdnraRatbisphenol F increases expressionISOEdnra (Mus musculus)6480464bisphenol F results in increased expression of EDNRA mRNACTDPMID:30951980EdnraRatbosentan multiple interactionsISOEDNRA (Homo sapiens)6480464bosentan binds to and results in decreased activity of EDNRA proteinCTDPMID:16219361EdnraRatbosentan multiple interactionsEXP 64804643 more ...CTDPMID:11093786 and PMID:15964565EdnraRatBQ 123 multiple interactionsEXP 64804643 more ...CTDPMID:11093786 more ...EdnraRatBQ 123 decreases activityISOEDNRA (Homo sapiens)6480464cyclo(Trp-Asp-Pro-Val-Leu) results in decreased activity of EDNRA proteinCTDPMID:18813882EdnraRatBQ 123 multiple interactionsISOEdnra (Mus musculus)6480464cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA proteinCTDPMID:15072961EdnraRatBQ 123 multiple interactionsISOEDNRA (Homo sapiens)6480464cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA proteinCTDPMID:11535565EdnraRatBQ 485 multiple interactionsEXP 6480464[BQ 485 binds to and results in decreased activity of EDNRA protein] which results in decreased expression of BCL2 proteinCTDPMID:14736733EdnraRatcadmium dichloride decreases expressionEXP 6480464Cadmium Chloride results in decreased expression of EDNRA mRNACTDPMID:33453195EdnraRatcalcium atom affects activityEXP 6480464Calcium affects the activity of EDNRA proteinCTDPMID:12628492EdnraRatcalcium(0) affects activityEXP 6480464Calcium affects the activity of EDNRA proteinCTDPMID:12628492EdnraRatcantharidin decreases expressionISOEdnra (Mus musculus)6480464Cantharidin results in decreased expression of EDNRA mRNACTDPMID:36907384EdnraRatcarbon nanotube increases expressionISOEDNRA (Homo sapiens)6480464Nanotubes and Carbon results in increased expression of EDNRA mRNACTDPMID:25511174EdnraRatcarbon nanotube decreases expressionISOEdnra (Mus musculus)6480464Nanotubes and Carbon analog results in decreased expression of EDNRA mRNACTDPMID:25620056EdnraRatcarmustine affects response to substanceISOEDNRA (Homo sapiens)6480464EDNRA mRNA affects the susceptibility to CarmustineCTDPMID:16365179EdnraRatcelecoxib multiple interactionsEXP 6480464Celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein]CTDPMID:25656942EdnraRatchromium(6+) affects expressionISOEdnra (Mus musculus)6480464chromium hexavalent ion affects the expression of EDNRA mRNACTDPMID:28472532EdnraRatcisplatin affects response to substanceISOEDNRA (Homo sapiens)6480464EDNRA protein affects the susceptibility to CisplatinCTDPMID:17032313EdnraRatcocaine increases expressionISOEDNRA (Homo sapiens)6480464Cocaine results in increased expression of EDNRA proteinCTDPMID:18813882EdnraRatcocaine increases expressionEXP 6480464Cocaine results in increased expression of EDNRA proteinCTDPMID:17420087EdnraRatCuprizon increases expressionEXP 6480464Cuprizone results in increased expression of EDNRA mRNACTDPMID:27523638EdnraRatcycloheximide multiple interactionsEXP 6480464[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA more ...CTDPMID:20561571EdnraRatcyclosporin A multiple interactionsEXP 6480464celecoxib inhibits the reaction [Cyclosporine results in increased expression of EDNRA protein]CTDPMID:25656942EdnraRatcyclosporin A increases expressionEXP 6480464Cyclosporine results in increased expression of EDNRA proteinCTDPMID:25656942EdnraRatD-glucose increases expressionISOEDNRA (Homo sapiens)6480464Glucose results in increased expression of EDNRA mRNACTDPMID:31655124EdnraRatdaunorubicin increases expressionEXP 6480464Daunorubicin results in increased expression of EDNRA proteinCTDPMID:20888384EdnraRatdaunorubicin multiple interactionsEXP 6480464telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]CTDPMID:20888384EdnraRatdecabromodiphenyl ether increases expressionEXP 6480464decabromobiphenyl ether results in increased expression of EDNRA mRNACTDPMID:23640034EdnraRatDeoxycorticosterone acetate multiple interactionsEXP 6480464[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDNRA mRNA and [Ozone co-treated with Oxygen] inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDNRA mRNA]CTDPMID:26550192EdnraRatdexamethasone decreases expressionISOEdnra (Mus musculus)6480464Dexamethasone results in decreased expression of EDNRA mRNACTDPMID:22733784EdnraRatdextran sulfate multiple interactionsISOEdnra (Mus musculus)6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EDNRA mRNACTDPMID:29950665EdnraRatdibutyl phthalate increases expressionEXP 6480464Dibutyl Phthalate results in increased expression of EDNRA mRNACTDPMID:21266533EdnraRatdibutyl phthalate increases expressionISOEdnra (Mus musculus)6480464Dibutyl Phthalate results in increased expression of EDNRA mRNACTDPMID:17361019EdnraRatdiethyl malate affects expressionISOEdnra (Mus musculus)6480464diethyl malate affects the expression of EDNRA mRNACTDPMID:24814887EdnraRatdimethyl sulfoxide multiple interactionsEXP 6480464[Dimethyl Sulfoxide co-treated with Cycloheximide] results in decreased expression of EDNRA mRNA more ...CTDPMID:20561571EdnraRatdioxygen increases expressionISOEdnra (Mus musculus)6480464Oxygen deficiency results in increased expression of EDNRA mRNA more ...CTDPMID:21926265 and PMID:25203536EdnraRatdioxygen multiple interactionsEXP 64804644-chlorobenzyltetrahydroberberine inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA] more ...CTDPMID:23270704 more ...EdnraRatdioxygen increases expressionEXP 6480464Oxygen deficiency results in increased expression of EDNRA mRNA and Oxygen deficiency results in increased expression of EDNRA proteinCTDPMID:23270704 more ...EdnraRatdioxygen multiple interactionsISOEdnra (Mus musculus)6480464rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA mRNA] and rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]CTDPMID:21926265EdnraRatdisodium selenite multiple interactionsISOEdnra (Mus musculus)6480464[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of EDNRA mRNACTDPMID:23274088EdnraRatdorsomorphin multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...CTDPMID:27188386EdnraRatdoxorubicin multiple interactionsEXP 6480464[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] affects the reaction [Doxorubicin results in increased activity of CASP3 protein]CTDPMID:14736733EdnraRatdoxorubicin decreases expressionISOEDNRA (Homo sapiens)6480464Doxorubicin results in decreased expression of EDNRA mRNACTDPMID:28940058 and PMID:29803840EdnraRatelemental selenium multiple interactionsISOEDNRA (Homo sapiens)6480464[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNACTDPMID:19244175EdnraRatelemental selenium decreases expressionISOEDNRA (Homo sapiens)6480464Selenium results in decreased expression of EDNRA mRNACTDPMID:19244175EdnraRatendosulfan increases expressionEXP 6480464Endosulfan results in increased expression of EDNRA mRNACTDPMID:29391264EdnraRatenrasentan multiple interactionsISOEDNRA (Homo sapiens)6480464enrasentan binds to and results in decreased activity of EDNRA proteinCTDPMID:16219361EdnraRatethanol increases expressionISOEdnra (Mus musculus)6480464Ethanol results in increased expression of EDNRA mRNACTDPMID:30319688EdnraRatethanol affects expressionISOEdnra (Mus musculus)6480464Ethanol affects the expression of EDNRA mRNACTDPMID:30319688EdnraRatfenvalerate decreases expressionEXP 6480464fenvalerate results in decreased expression of EDNRA mRNACTDPMID:30307764EdnraRatfluvastatin decreases expressionEXP 6480464fluvastatin results in decreased expression of EDNRA mRNACTDPMID:28951255EdnraRatfolic acid multiple interactionsISOEdnra (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of EDNRA mRNACTDPMID:22206623EdnraRatfructose multiple interactionsEXP 6480464KLK1 protein inhibits the reaction [Fructose results in increased expression of EDNRA mRNA]CTDPMID:14568997EdnraRatfructose increases expressionISOEDNRA (Homo sapiens)6480464Fructose results in increased expression of EDNRA mRNACTDPMID:31655124EdnraRatfructose increases expressionEXP 6480464Fructose results in increased expression of EDNRA mRNACTDPMID:14568997 and PMID:9869011EdnraRatfulvestrant multiple interactionsISOEDNRA (Homo sapiens)6480464[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNACTDPMID:19943105EdnraRatfulvestrant increases methylationISOEDNRA (Homo sapiens)6480464Fulvestrant results in increased methylation of EDNRA geneCTDPMID:31601247EdnraRatfuran decreases expressionEXP 6480464furan results in decreased expression of EDNRA mRNACTDPMID:25539665EdnraRatfuran increases expressionEXP 6480464furan results in increased expression of EDNRA mRNACTDPMID:27387713EdnraRatglucose increases expressionISOEDNRA (Homo sapiens)6480464Glucose results in increased expression of EDNRA mRNACTDPMID:31655124EdnraRathexadecanoic acid multiple interactionsISOEDNRA (Homo sapiens)6480464Agmatine inhibits the reaction [Palmitic Acid results in decreased expression of EDNRA protein]CTDPMID:35747990EdnraRathexadecanoic acid decreases expressionISOEDNRA (Homo sapiens)6480464Palmitic Acid results in decreased expression of EDNRA proteinCTDPMID:35747990EdnraRathydrogen cyanide decreases expressionISOEdnra (Mus musculus)6480464Hydrogen Cyanide results in decreased expression of EDNRA mRNACTDPMID:33914522EdnraRatinulin multiple interactionsISOEdnra (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of EDNRA mRNACTDPMID:36331819EdnraRatisoprenaline increases expressionISOEdnra (Mus musculus)6480464Isoproterenol results in increased expression of EDNRA mRNACTDPMID:20003209EdnraRatisoprenaline multiple interactionsEXP 6480464CPU0213 inhibits the reaction [Isoproterenol results in increased expression of EDNRA mRNA] more ...CTDPMID:18594475 more ...EdnraRatisoprenaline increases expressionEXP 6480464Isoproterenol results in increased expression of EDNRA mRNA and Isoproterenol results in increased expression of EDNRA proteinCTDPMID:18594475 more ...EdnraRatisoquinoline-1,5-diol decreases expressionEXP 64804641 and 5-dihydroxyisoquinoline results in decreased expression of EDNRA mRNACTDPMID:12824290EdnraRatLicochalcone B decreases expressionISOEDNRA (Homo sapiens)6480464licochalcone B results in decreased expression of EDNRA mRNACTDPMID:33647349EdnraRatlipopolysaccharide multiple interactionsISOEDNRA (Homo sapiens)6480464[S-(1 more ...CTDPMID:35811015EdnraRatlipopolysaccharide decreases expressionISOEDNRA (Homo sapiens)6480464Lipopolysaccharides results in decreased expression of EDNRA mRNACTDPMID:35811015EdnraRatlosartan multiple interactionsEXP 6480464Atorvastatin promotes the reaction [Losartan results in decreased expression of EDNRA mRNA] and Losartan promotes the reaction [Atorvastatin results in decreased expression of EDNRA mRNA]CTDPMID:23091284EdnraRatlosartan decreases expressionEXP 6480464Losartan results in decreased expression of EDNRA mRNACTDPMID:23091284EdnraRatMagnolol multiple interactionsEXP 6480464magnolol inhibits the reaction [Monocrotaline results in increased expression of EDNRA protein]CTDPMID:30466619EdnraRatmethimazole increases expressionEXP 6480464Methimazole results in increased expression of EDNRA mRNACTDPMID:30047161EdnraRatmethylmercury chloride decreases expressionISOEDNRA (Homo sapiens)6480464methylmercuric chloride results in decreased expression of EDNRA mRNACTDPMID:28001369EdnraRatmethylseleninic acid increases expressionISOEDNRA (Homo sapiens)6480464methylselenic acid results in increased expression of EDNRA mRNACTDPMID:18548127EdnraRatmifepristone decreases expressionEXP 6480464Mifepristone results in decreased expression of EDNRA mRNACTDPMID:25972201EdnraRatmonocrotaline multiple interactionsEXP 6480464magnolol inhibits the reaction [Monocrotaline results in increased expression of EDNRA protein] and Simvastatin inhibits the reaction [Monocrotaline results in increased expression of EDNRA mRNA]CTDPMID:22022327 and PMID:30466619EdnraRatmonocrotaline increases expressionEXP 6480464Monocrotaline results in increased expression of EDNRA mRNA and Monocrotaline results in increased expression of EDNRA proteinCTDPMID:20967148 more ...EdnraRatN(gamma)-nitro-L-arginine methyl ester multiple interactionsEXP 6480464Atrasentan inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of EDNRA mRNA]CTDPMID:34102242EdnraRatN(gamma)-nitro-L-arginine methyl ester increases expressionEXP 6480464NG-Nitroarginine Methyl Ester results in increased expression of EDNRA mRNACTDPMID:34102242EdnraRatnicotine decreases expressionISOEDNRA (Homo sapiens)6480464Nicotine results in decreased expression of EDNRA mRNACTDPMID:18247414EdnraRatnitrofen decreases expressionISOEdnra (Mus musculus)6480464nitrofen results in decreased expression of EDNRA mRNACTDPMID:12407540EdnraRatnitrofen increases expressionEXP 6480464nitrofen results in increased expression of EDNRA mRNA and nitrofen results in increased expression of EDNRA proteinCTDPMID:10693666 more ...EdnraRatouabain increases expressionEXP 6480464Ouabain results in increased expression of EDNRA mRNA and Ouabain results in increased expression of EDNRA proteinCTDPMID:15477225 and PMID:16982439EdnraRatozone decreases expressionEXP 6480464Ozone results in decreased expression of EDNRA mRNACTDPMID:16081523EdnraRatozone multiple interactionsISOEdnra (Mus musculus)6480464[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of EDNRA mRNACTDPMID:34911549EdnraRatozone multiple interactionsEXP 6480464[Ozone co-treated with Oxygen] inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDNRA mRNA]CTDPMID:26550192EdnraRatozone multiple interactionsISOEDNRA (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of EDNRA mRNA more ...CTDPMID:32699268EdnraRatozone increases expressionEXP 6480464Ozone results in increased expression of EDNRA mRNACTDPMID:20980218EdnraRatpanobinostat increases expressionISOEDNRA (Homo sapiens)6480464panobinostat results in increased expression of EDNRA mRNACTDPMID:26272509EdnraRatpanobinostat multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNACTDPMID:27188386EdnraRatparacetamol increases expressionISOEDNRA (Homo sapiens)6480464Acetaminophen results in increased expression of EDNRA mRNACTDPMID:29067470EdnraRatparaquat affects expressionEXP 6480464Paraquat affects the expression of EDNRA mRNACTDPMID:16854511EdnraRatparaquat decreases expressionISOEDNRA (Homo sapiens)6480464Paraquat results in decreased expression of EDNRA mRNACTDPMID:35182771EdnraRatperfluorohexanesulfonic acid increases expressionISOEdnra (Mus musculus)6480464perfluorohexanesulfonic acid results in increased expression of EDNRA mRNACTDPMID:37995155EdnraRatperfluorooctane-1-sulfonic acid multiple interactionsISOEdnra (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of EDNRA mRNACTDPMID:36331819EdnraRatphenylephrine multiple interactionsEXP 6480464[cyclo(Trp-Asp-Pro-Val-Leu) binds to and results in decreased activity of EDNRA protein] which results in decreased susceptibility to Phenylephrine and phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]CTDPMID:15007106EdnraRatphenylmercury acetate increases expressionISOEDNRA (Homo sapiens)6480464Phenylmercuric Acetate results in increased expression of EDNRA mRNACTDPMID:26272509EdnraRatphenylmercury acetate multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNACTDPMID:27188386EdnraRatphosphoramidon multiple interactionsEXP 6480464phosphoramidon inhibits the reaction [AGT protein results in increased expression of EDNRA protein] and phosphoramidon inhibits the reaction [Phenylephrine results in increased expression of EDNRA protein]CTDPMID:15007106EdnraRatpirinixic acid decreases expressionISOEdnra (Mus musculus)6480464pirinixic acid results in decreased expression of EDNRA mRNACTDPMID:16985257EdnraRatpotassium chloride multiple interactionsISOEdnra (Mus musculus)6480464[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA proteinCTDPMID:18516094EdnraRatpotassium cyanide decreases expressionISOEdnra (Mus musculus)6480464Potassium Cyanide results in decreased expression of EDNRA mRNACTDPMID:33914522EdnraRatpotassium dichromate increases expressionISOEdnra (Mus musculus)6480464Potassium Dichromate results in increased expression of EDNRA mRNACTDPMID:23608068EdnraRatpregnenolone 16alpha-carbonitrile increases expressionEXP 6480464Pregnenolone Carbonitrile results in increased expression of EDNRA mRNACTDPMID:30047161EdnraRatprogesterone decreases expressionISOEDNRA (Homo sapiens)6480464Progesterone results in decreased expression of EDNRA mRNACTDPMID:21795739EdnraRatPtaquiloside multiple interactionsISOEdnra (Mus musculus)6480464[ptaquiloside co-treated with Sodium Selenite] results in decreased expression of EDNRA mRNACTDPMID:23274088EdnraRatquartz decreases expressionISOEDNRA (Homo sapiens)6480464Quartz results in decreased expression of EDNRA mRNACTDPMID:27917503EdnraRatraloxifene multiple interactionsISOEDNRA (Homo sapiens)6480464[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of EDNRA mRNA and [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of EDNRA mRNACTDPMID:19059307EdnraRatreactive oxygen species multiple interactionsEXP 6480464[5-(dimethylamino)-N-(3 and 4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide binds to and results in decreased activity of EDNRA protein] inhibits the reaction [Desoxycorticosterone results in increased chemical synthesis of Reactive Oxygen Species]CTDPMID:16271043EdnraRatrebaudioside A increases expressionISOEDNRA (Homo sapiens)6480464rebaudioside A results in increased expression of EDNRA mRNACTDPMID:31655124EdnraRatresveratrol multiple interactionsEXP 6480464Resveratrol inhibits the reaction [Smoke results in increased expression of EDNRA protein] and Resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of EDNRA protein]CTDPMID:36183783EdnraRatrotenone decreases expressionISOEdnra (Mus musculus)6480464Rotenone results in decreased expression of EDNRA mRNACTDPMID:35919817EdnraRatrotenone increases expressionISOEDNRA (Homo sapiens)6480464Rotenone results in increased expression of EDNRA mRNACTDPMID:37210002EdnraRatS-(1,2-dichlorovinyl)-L-cysteine multiple interactionsISOEDNRA (Homo sapiens)6480464[S-(1 more ...CTDPMID:35811015EdnraRatSB 203580 multiple interactionsEXP 6480464SB 203580 inhibits the reaction [Smoke results in increased expression of EDNRA protein]CTDPMID:36183783EdnraRatSB 431542 multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with belinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ...CTDPMID:27188386EdnraRatselenium atom multiple interactionsISOEDNRA (Homo sapiens)6480464[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNACTDPMID:19244175EdnraRatselenium atom decreases expressionISOEDNRA (Homo sapiens)6480464Selenium results in decreased expression of EDNRA mRNACTDPMID:19244175EdnraRatsilicon dioxide decreases expressionISOEDNRA (Homo sapiens)6480464Silicon Dioxide analog results in decreased expression of EDNRA mRNA and Silicon Dioxide results in decreased expression of EDNRA mRNACTDPMID:25351596 and PMID:25895662EdnraRatsimvastatin multiple interactionsEXP 6480464Simvastatin inhibits the reaction [Cholesterol more ...CTDPMID:19505368 and PMID:22022327EdnraRatsodium arsenite multiple interactionsISOEDNRA (Homo sapiens)6480464EDNRA protein affects the reaction [sodium arsenite results in decreased expression of PLIN1 protein] and sodium arsenite results in decreased expression of and affects the splicing of EDNRA mRNACTDPMID:23650128 and PMID:25879800EdnraRatsodium chloride multiple interactionsISOEdnra (Mus musculus)6480464[19-oxo-11-deoxycorticosterone acetate co-treated with Potassium Chloride co-treated with Sodium Chloride] affects the activity of EDNRA proteinCTDPMID:18516094EdnraRatsodium chloride multiple interactionsEXP 6480464[Desoxycorticosterone Acetate co-treated with Sodium Chloride] results in increased expression of EDNRA mRNA more ...CTDPMID:22431579 and PMID:26550192EdnraRatsteviol increases expressionISOEDNRA (Homo sapiens)6480464steviol results in increased expression of EDNRA mRNACTDPMID:31655124EdnraRatstevioside increases expressionISOEDNRA (Homo sapiens)6480464stevioside results in increased expression of EDNRA mRNACTDPMID:31655124EdnraRatsulfadimethoxine increases expressionEXP 6480464Sulfadimethoxine results in increased expression of EDNRA mRNACTDPMID:30047161EdnraRatsulforaphane decreases expressionISOEDNRA (Homo sapiens)6480464sulforaphane results in decreased expression of EDNRA mRNACTDPMID:31838189EdnraRatsunitinib decreases expressionISOEDNRA (Homo sapiens)6480464Sunitinib results in decreased expression of EDNRA mRNACTDPMID:31533062EdnraRatsuperoxide affects abundanceEXP 6480464EDNRA protein affects the abundance of SuperoxidesCTDPMID:12600921EdnraRattacrolimus hydrate increases activityEXP 6480464Tacrolimus results in increased activity of EDNRA proteinCTDPMID:15964565EdnraRattacrolimus hydrate increases expressionEXP 6480464Tacrolimus results in increased expression of EDNRA mRNACTDPMID:8587392EdnraRattamoxifen multiple interactionsISOEDNRA (Homo sapiens)6480464[fulvestrant co-treated with Tamoxifen co-treated with ZD4054] results in decreased expression of EDNRA mRNA more ...CTDPMID:19059307 and PMID:19943105EdnraRattamoxifen increases expressionISOEDNRA (Homo sapiens)6480464Tamoxifen results in increased expression of EDNRA mRNACTDPMID:19943105EdnraRatTanshinone I multiple interactionsEXP 6480464tanshinone inhibits the reaction [Oxygen deficiency results in increased expression of EDNRA protein]CTDPMID:28985491EdnraRattelmisartan multiple interactionsEXP 6480464telmisartan inhibits the reaction [Daunorubicin results in increased expression of EDNRA protein]CTDPMID:20888384EdnraRattemozolomide affects response to substanceISOEDNRA (Homo sapiens)6480464EDNRA mRNA affects the susceptibility to temozolomideCTDPMID:16365179EdnraRattemozolomide decreases expressionISOEDNRA (Homo sapiens)6480464Temozolomide results in decreased expression of EDNRA mRNACTDPMID:31758290EdnraRattestosterone affects expressionEXP 6480464Testosterone affects the expression of EDNRA mRNACTDPMID:12122504 and PMID:14616470EdnraRattestosterone enanthate affects expressionISOEDNRA (Homo sapiens)6480464testosterone enanthate affects the expression of EDNRA mRNACTDPMID:17440010EdnraRattetrachloromethane decreases expressionISOEdnra (Mus musculus)6480464Carbon Tetrachloride results in decreased expression of EDNRA mRNACTDPMID:17484886EdnraRatthioacetamide affects expressionEXP 6480464Thioacetamide affects the expression of EDNRA mRNACTDPMID:34492290EdnraRattitanium dioxide affects expressionISOEdnra (Mus musculus)6480464titanium dioxide affects the expression of EDNRA mRNACTDPMID:23557971EdnraRattitanium dioxide multiple interactionsISOEdnra (Mus musculus)6480464[titanium dioxide co-treated with Azoxymethane co-treated with Dextran Sulfate] results in decreased expression of EDNRA mRNACTDPMID:29950665EdnraRattrichloroethene increases methylationEXP 6480464Trichloroethylene results in increased methylation of EDNRA geneCTDPMID:27618143EdnraRattrichloroethene increases expressionEXP 6480464Trichloroethylene results in increased expression of EDNRA mRNACTDPMID:33387578EdnraRattrichostatin A increases expressionISOEDNRA (Homo sapiens)6480464trichostatin A results in increased expression of EDNRA mRNACTDPMID:24935251 and PMID:26272509EdnraRattrichostatin A multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNACTDPMID:27188386EdnraRattriclosan decreases expressionISOEDNRA (Homo sapiens)6480464Triclosan results in decreased expression of EDNRA mRNACTDPMID:30510588EdnraRatvalproic acid decreases expressionISOEDNRA (Homo sapiens)6480464Valproic Acid results in decreased expression of EDNRA mRNACTDPMID:23179753 and PMID:28001369EdnraRatvalproic acid multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNACTDPMID:27188386EdnraRatvalproic acid increases expressionISOEDNRA (Homo sapiens)6480464Valproic Acid results in increased expression of EDNRA mRNACTDPMID:23179753 more ...EdnraRatvalproic acid increases expressionISOEdnra (Mus musculus)6480464Valproic Acid results in increased expression of EDNRA mRNACTDPMID:24896083EdnraRatvalproic acid affects expressionISOEDNRA (Homo sapiens)6480464Valproic Acid affects the expression of EDNRA mRNACTDPMID:25979313EdnraRatvalsartan decreases expressionEXP 6480464Valsartan results in decreased expression of EDNRA mRNACTDPMID:28951255EdnraRatvinclozolin increases expressionEXP 6480464vinclozolin results in increased expression of EDNRA mRNACTDPMID:20566332EdnraRatvinclozolin affects expressionEXP 6480464vinclozolin affects the expression of EDNRA mRNACTDPMID:19015723EdnraRatvitamin E multiple interactionsISOEDNRA (Homo sapiens)6480464[Selenium co-treated with Vitamin E] results in increased expression of EDNRA mRNACTDPMID:19244175EdnraRatvitamin E decreases expressionISOEDNRA (Homo sapiens)6480464Vitamin E results in decreased expression of EDNRA mRNACTDPMID:19244175EdnraRatvorinostat multiple interactionsISOEDNRA (Homo sapiens)6480464[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EDNRA mRNACTDPMID:27188386EdnraRatvorinostat increases expressionISOEDNRA (Homo sapiens)6480464vorinostat results in increased expression of EDNRA mRNACTDPMID:26272509
Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatadenylate cyclase-inhibiting G protein-coupled receptor signaling pathway acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:88121 PMID:15928212RGDPMID:15928212EdnraRatangiogenesis involved_inISOEdnra (Mus musculus)1624291MGI:95284 PMID:24043815RGDPMID:24043815EdnraRataorta development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRataorta development involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:14585980 and PMID:31219639EdnraRatartery smooth muscle contraction involved_inIEAUniProtKB:P25101 and ensembl:ENSP000004989691600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatartery smooth muscle contraction involved_inISOEDNRA (Homo sapiens)1624291 PMID:8982507RGDPMID:8982507EdnraRatatrial cardiac muscle tissue development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatatrial cardiac muscle tissue development involved_inISOEdnra (Mus musculus)1624291MGI:3773698 more ...RGDPMID:20929948EdnraRataxon extension involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRataxon extension involved_inISOEdnra (Mus musculus)1624291 PMID:18401410RGDPMID:18401410EdnraRataxon guidance involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:18401410 and PMID:30735130EdnraRataxonogenesis involved in innervation involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRataxonogenesis involved in innervation involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:24875861 and PMID:30735130EdnraRatblood vessel remodeling involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatblood vessel remodeling involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:25197047RGDPMID:25197047EdnraRatbranching involved in blood vessel morphogenesis involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatbranching involved in blood vessel morphogenesis involved_inISOEdnra (Mus musculus)1624291MGI:3773698 more ...RGDPMID:23933587EdnraRatbranching involved in blood vessel morphogenesis acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:1347481 PMID:15664398RGDPMID:15664398EdnraRatcalcium ion transmembrane transport involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcalcium ion transmembrane transport involved_inISOEdnra (Mus musculus)1624291MGI:102720 PMID:24722437RGDPMID:24722437EdnraRatcanonical Wnt signaling pathway involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcanonical Wnt signaling pathway involved_inISOEdnra (Mus musculus)1624291MGI:102720 PMID:24722437RGDPMID:24722437EdnraRatcardiac chamber formation involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcardiac chamber formation involved_inISOEdnra (Mus musculus)1624291MGI:3773698 more ...RGDPMID:20929948EdnraRatcardiac neural crest cell migration involved in outflow tract morphogenesis involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcardiac neural crest cell migration involved in outflow tract morphogenesis involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:31219639EdnraRatcellular response to follicle-stimulating hormone stimulus involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcellular response to follicle-stimulating hormone stimulus involved_inISOEdnra (Mus musculus)1624291 PMID:19111534RGDPMID:19111534EdnraRatcellular response to human chorionic gonadotropin stimulus involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcellular response to human chorionic gonadotropin stimulus involved_inISOEdnra (Mus musculus)1624291 PMID:19111534RGDPMID:19111534EdnraRatcellular response to luteinizing hormone stimulus involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcellular response to luteinizing hormone stimulus involved_inISOEdnra (Mus musculus)1624291 PMID:19111534RGDPMID:19111534EdnraRatcellular response to mechanical stimulus  IMP 4889461 RGD EdnraRatcellular response to oxidative stress involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcellular response to oxidative stress involved_inISOEdnra (Mus musculus)1624291 PMID:27899487RGDPMID:27899487EdnraRatcranial skeletal system development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatcranial skeletal system development involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:17294360 more ...EdnraRatdevelopmental pigmentation involved_inIBAMGI:102720 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033EdnraRatembryonic heart tube development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatembryonic heart tube development involved_inISOEdnra (Mus musculus)1624291MGI:105923 more ...RGDPMID:20929948 more ...EdnraRatembryonic skeletal system development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatembryonic skeletal system development involved_inISOEdnra (Mus musculus)1624291MGI:103580 PMID:19017795RGDPMID:19017795EdnraRatendothelin receptor signaling pathway involved_inIEAGO:00049621600115GO_REF:0000108GOCGO_REF:0000108EdnraRatendothelin receptor signaling pathway involved_inISOEdnra (Mus musculus)1624291MGI:102720 PMID:24722437RGDPMID:24722437EdnraRatendothelin receptor signaling pathway involved_inIBAMGI:102720 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033EdnraRatendothelin receptor signaling pathway involved in heart process involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatendothelin receptor signaling pathway involved in heart process involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:31219639RGDPMID:31219639EdnraRatenteric nervous system development involved_inIEAInterPro:IPR0004991600115GO_REF:0000002InterProGO_REF:0000002EdnraRatestablishment of endothelial barrier involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatestablishment of endothelial barrier involved_inISOEdnra (Mus musculus)1624291 PMID:27026367RGDPMID:27026367EdnraRatface development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatface development involved_inISOEdnra (Mus musculus)1624291MGI:3773699 PMID:18199583RGDPMID:18199583EdnraRatfibroblast proliferation  IMP 4892344 RGD EdnraRatgene expression involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatgene expression involved_inISOEdnra (Mus musculus)1624291MGI:102720 more ...RGDPMID:20929948 more ...EdnraRatglomerular endothelium development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatglomerular endothelium development involved_inISOEdnra (Mus musculus)1624291 PMID:31402170RGDPMID:31402170EdnraRatglomerular filtration  IMP 4892335 RGD EdnraRatglomerular filtration involved_inISOEdnra (Mus musculus)1624291 PMID:31402170RGDPMID:31402170EdnraRatglomerular filtration involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatglomerulus development involved_inISOEdnra (Mus musculus)1624291 PMID:27899487RGDPMID:27899487EdnraRathead development acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:1857473 PMID:15306564RGDPMID:15306564EdnraRatheart development acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:1347481 PMID:15664398RGDPMID:15664398EdnraRatheart development involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:24875861 and PMID:25197047EdnraRatheart process involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:25197047 and PMID:31219639RGDPMID:25197047 and PMID:31219639EdnraRatheparin metabolic process involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatheparin metabolic process involved_inISOEdnra (Mus musculus)1624291MGI:102720 more ...RGDPMID:27026367EdnraRathistamine secretion  IMP 4892576 RGD EdnraRatin utero embryonic development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatin utero embryonic development acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291 PMID:15327783RGDPMID:15327783EdnraRatintracellular calcium ion homeostasis involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatintracellular calcium ion homeostasis involved_inISOEDNRA (Homo sapiens)1624291 PMID:30990108RGDPMID:30990108EdnraRatintracellular calcium ion homeostasis involved_inIEAUniProtKB:P25101 and ensembl:ENSP000004989691600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatleft ventricular cardiac muscle tissue morphogenesis involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatleft ventricular cardiac muscle tissue morphogenesis involved_inISOEdnra (Mus musculus)1624291MGI:3773698 more ...RGDPMID:20929948EdnraRatmaternal process involved in parturition  IEP 4892575 RGD EdnraRatmeiotic cell cycle process involved in oocyte maturation involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatmeiotic cell cycle process involved in oocyte maturation involved_inISOEdnra (Mus musculus)1624291 PMID:19111534RGDPMID:19111534EdnraRatmesenchymal cell apoptotic process involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatmesenchymal cell apoptotic process involved_inISOEdnra (Mus musculus)1624291MGI:1857473 PMID:17294360RGDPMID:17294360EdnraRatmiddle ear morphogenesis involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatmiddle ear morphogenesis involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:19185569RGDPMID:19185569EdnraRatmitochondrion organization involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatmitochondrion organization involved_inISOEdnra (Mus musculus)1624291 PMID:27899487RGDPMID:27899487EdnraRatmitotic cell cycle involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatmitotic cell cycle involved_inISOEdnra (Mus musculus)1624291MGI:3773699 PMID:20929948RGDPMID:20929948EdnraRatnegative regulation of apoptotic process  IMP 4892573 RGD EdnraRatneural crest cell development acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:1857473 PMID:15306564 more ...RGDPMID:15306564 more ...EdnraRatneural crest cell differentiation involved_inISOEdnra (Mus musculus)1624291MGI:102780 more ...RGDPMID:19185569 more ...EdnraRatneural crest cell fate commitment involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatneural crest cell fate commitment involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:17294360 and PMID:23933587EdnraRatneuromuscular process involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatneuromuscular process involved_inISOEdnra (Mus musculus)1624291MGI:3773699 PMID:19017795RGDPMID:19017795EdnraRatneuron projection development involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:24875861 and PMID:30735130EdnraRatneuron remodeling involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatneuron remodeling involved_inISOEdnra (Mus musculus)1624291MGI:3773699 PMID:19017795RGDPMID:19017795EdnraRatnoradrenergic neuron differentiation involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatnoradrenergic neuron differentiation involved_inISOEdnra (Mus musculus)1624291MGI:1857473 PMID:24875861RGDPMID:24875861EdnraRatnorepinephrine metabolic process involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatnorepinephrine metabolic process involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:25197047RGDPMID:25197047EdnraRatpharyngeal arch artery morphogenesis involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatpharyngeal arch artery morphogenesis involved_inISOEdnra (Mus musculus)1624291MGI:1857473 more ...RGDPMID:23933587 and PMID:31219639EdnraRatphospholipase C-activating G protein-coupled receptor signaling pathway  IMP 728499 RGD EdnraRatpodocyte apoptotic process involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatpodocyte apoptotic process involved_inISOEdnra (Mus musculus)1624291 PMID:27899487RGDPMID:27899487EdnraRatpodocyte differentiation involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatpodocyte differentiation involved_inISOEdnra (Mus musculus)1624291MGI:102720 more ...RGDPMID:24722437 and PMID:31402170EdnraRatpositive regulation of calcium ion transport  IMP 728499 RGD EdnraRatpositive regulation of canonical NF-kappaB signal transduction involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatpositive regulation of canonical NF-kappaB signal transduction involved_inISOEdnra (Mus musculus)1624291 PMID:24722437RGDPMID:24722437EdnraRatpositive regulation of cell population proliferation  IMP 4892573 RGD EdnraRatpositive regulation of cytosolic calcium ion concentration  IDA 728424 RGD EdnraRatpositive regulation of ERK1 and ERK2 cascade  IMP 4892323 RGD EdnraRatpositive regulation of kidney development  IMP 4892573 RGD EdnraRatpositive regulation of neutrophil chemotaxis  IMP 4892576 RGD EdnraRatpositive regulation of odontogenesis  IMP 4892598 RGD EdnraRatpositive regulation of protein phosphorylation  IMP 1581836 RGD EdnraRatpositive regulation of release of sequestered calcium ion into cytosol  IMP 728499 RGD EdnraRatprotein kinase A signaling involved_inIEAUniProtKB:P25101 and ensembl:ENSP000004989691600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatprotein kinase A signaling involved_inISOEDNRA (Homo sapiens)1624291 PMID:30990108RGDPMID:30990108EdnraRatprotein kinase C-activating G protein-coupled receptor signaling pathway  IMP 728499 RGD EdnraRatprotein transmembrane transport involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatprotein transmembrane transport involved_inISOEdnra (Mus musculus)1624291 PMID:27026367RGDPMID:27026367EdnraRatregulation of blood pressure involved_inIEAInterPro:IPR000499 and InterPro:IPR0021751600115GO_REF:0000002InterProGO_REF:0000002EdnraRatregulation of blood pressure involved_inISOEdnra (Mus musculus)1624291MGI:102720 more ...RGDPMID:16399858 more ...EdnraRatregulation of blood pressure NOT|acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:3044563 more ...RGDPMID:15928212EdnraRatregulation of blood pressure involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatregulation of epithelial cell proliferation  IMP 1581844 RGD EdnraRatregulation of glucose transmembrane transport involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatregulation of glucose transmembrane transport acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291 PMID:11546805RGDPMID:11546805EdnraRatregulation of heart rate involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatregulation of heart rate involved_inISOEdnra (Mus musculus)1624291MGI:102720 PMID:16399858RGDPMID:16399858EdnraRatregulation of protein localization to cell leading edge involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatregulation of protein localization to cell leading edge involved_inISOEdnra (Mus musculus)1624291MGI:1857473 PMID:31219639RGDPMID:31219639EdnraRatrenal albumin absorption involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatrenal albumin absorption involved_inISOEdnra (Mus musculus)1624291MGI:102720 more ...RGDPMID:24722437 more ...EdnraRatrenal sodium ion absorption involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatrenal sodium ion absorption involved_inISOEdnra (Mus musculus)1624291 PMID:23698114RGDPMID:23698114EdnraRatrespiratory gaseous exchange by respiratory system involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatrespiratory gaseous exchange by respiratory system acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:1857473 PMID:10626068 and PMID:9449664RGDPMID:10626068 and PMID:9449664EdnraRatresponse to acetylcholine involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatresponse to acetylcholine involved_inISOEdnra (Mus musculus)1624291 PMID:26531127RGDPMID:26531127EdnraRatresponse to amphetamine involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatresponse to amphetamine involved_inISOEdnra (Mus musculus)1624291MGI:1857473 PMID:24875861RGDPMID:24875861EdnraRatresponse to hypoxia involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatresponse to hypoxia acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291MGI:1857473 PMID:9449664RGDPMID:9449664EdnraRatresponse to lipopolysaccharide  IMP 4892341 RGD EdnraRatresponse to organic cyclic compound  IEP 4892287 RGD EdnraRatresponse to wounding involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatresponse to wounding involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:25197047RGDPMID:25197047EdnraRatRho protein signal transduction  IMP 4892323 RGD EdnraRatsemaphorin-plexin signaling pathway involved in axon guidance involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatsemaphorin-plexin signaling pathway involved in axon guidance involved_inISOEdnra (Mus musculus)1624291MGI:1857637 more ...RGDPMID:30735130EdnraRatsmooth muscle cell proliferation  IMP 4892323 RGD EdnraRatsodium ion homeostasis involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatsodium ion homeostasis involved_inISOEdnra (Mus musculus)1624291MGI:102720 PMID:18784261RGDPMID:18784261EdnraRatsympathetic nervous system development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatsympathetic nervous system development involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:25197047RGDPMID:25197047EdnraRatsympathetic neuron axon guidance involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatsympathetic neuron axon guidance involved_inISOEdnra (Mus musculus)1624291MGI:2179061 PMID:30735130RGDPMID:30735130EdnraRatthyroid gland development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatthyroid gland development involved_inISOEdnra (Mus musculus)1624291MGI:4867385 PMID:26506449RGDPMID:26506449EdnraRatvascular associated smooth muscle cell development involved_inIEAUniProtKB:Q61614 and ensembl:ENSMUSP000000340291600115GO_REF:0000107EnsemblGO_REF:0000107EdnraRatvascular associated smooth muscle cell development involved_inISOEdnra (Mus musculus)1624291MGI:2687362 PMID:24412386RGDPMID:24412386EdnraRatvasoconstriction  IMP 1581832 RGD EdnraRatvasoconstriction acts_upstream_of_or_withinISOEdnra (Mus musculus)1624291 PMID:9826706RGDPMID:9826706EdnraRatvasoconstriction involved_inIBAMGI:105923 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033EdnraRatvasoconstriction involved_inIEAInterPro:IPR000499 and InterPro:IPR0021751600115GO_REF:0000002InterProGO_REF:0000002EdnraRatvasoconstriction involved_inISOEDNRA (Homo sapiens)1624291 PMID:8982507RGDPMID:8982507

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatcell periphery is_active_inISOEdnra (Mus musculus)1624291 PMID:30990108RGDPMID:30990108EdnraRatnuclear membrane  IDA 1581838 RGD EdnraRatplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044EdnraRatplasma membrane is_active_inIBAPANTHER:PTN002517505 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033EdnraRatT-tubule  IDA 1581834 RGD 

Molecular Function

  

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatendothelin signaling pathway  IMP 4892591 RGD EdnraRatinflammatory response pathway  IMP 4892591 RGD EdnraRatRho/Rac/Cdc42 mediated signaling pathway  IMP 4892323 RGD 

Imported Annotations - KEGG (archival)

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatcalcium/calcium-mediated signaling pathway   IEA 6907045 KEGGrno:04020

Imported Annotations - PID (archival)

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatendothelin signaling pathway  ISOEDNRA (Homo sapiens)6484113 PIDPID:200005
Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)EdnraRatglomerulosclerosis  IDA 1581830 RGD EdnraRatheart left ventricle hypertrophy  IDA 1581830 RGD EdnraRatincreased systemic arterial systolic blood pressure  IDA 1581830 RGD EdnraRatkidney cyst  IMP 1581844 RGD EdnraRatrenal interstitial fibrosis  IMP 1581844 RGD 
Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-noradrenaline  (EXP)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
11-deoxycorticosterone  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-naphthylamine  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-(dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide  (EXP)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acadesine  (EXP)
acetamide  (EXP)
acrolein  (ISO)
actinomycin D  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
agmatine  (ISO)
aldehydo-D-glucose  (ISO)
aldosterone  (EXP)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ambrisentan  (ISO)
aminoguanidine  (EXP)
amitrole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apocynin  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
aspartame  (ISO)
atorvastatin calcium  (EXP)
atrasentan  (EXP,ISO)
atrazine  (EXP)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bosentan  (EXP,ISO)
BQ 123  (EXP,ISO)
BQ 485  (EXP)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
cantharidin  (ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
celecoxib  (EXP)
chromium(6+)  (ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
Cuprizon  (EXP)
cycloheximide  (EXP)
cyclosporin A  (EXP)
D-glucose  (ISO)
daunorubicin  (EXP)
decabromodiphenyl ether  (EXP)
Deoxycorticosterone acetate  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (EXP,ISO)
diethyl malate  (ISO)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
enrasentan  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
fluvastatin  (EXP)
folic acid  (ISO)
fructose  (EXP,ISO)
fulvestrant  (ISO)
furan  (EXP)
glucose  (ISO)
hexadecanoic acid  (ISO)
hydrogen cyanide  (ISO)
inulin  (ISO)
isoprenaline  (EXP,ISO)
isoquinoline-1,5-diol  (EXP)
Licochalcone B  (ISO)
lipopolysaccharide  (ISO)
losartan  (EXP)
Magnolol  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
monocrotaline  (EXP)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
nicotine  (ISO)
nitrofen  (EXP,ISO)
ouabain  (EXP)
ozone  (EXP,ISO)
panobinostat  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
phosphoramidon  (EXP)
pirinixic acid  (ISO)
potassium chloride  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
Ptaquiloside  (ISO)
quartz  (ISO)
raloxifene  (ISO)
reactive oxygen species  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 203580  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
simvastatin  (EXP)
sodium arsenite  (ISO)
sodium chloride  (EXP,ISO)
steviol  (ISO)
stevioside  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
superoxide  (EXP)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
Tanshinone I  (EXP)
telmisartan  (EXP)
temozolomide  (ISO)
testosterone  (EXP)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (ISO)
valsartan  (EXP)
vinclozolin  (EXP)
vitamin E  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (IEA,ISO)
angiogenesis  (ISO)
aorta development  (IEA,ISO)
artery smooth muscle contraction  (IEA,ISO)
atrial cardiac muscle tissue development  (IEA,ISO)
axon extension  (IEA,ISO)
axon guidance  (ISO)
axonogenesis involved in innervation  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
branching involved in blood vessel morphogenesis  (IEA,ISO)
calcium ion transmembrane transport  (IEA,ISO)
canonical Wnt signaling pathway  (IEA,ISO)
cardiac chamber formation  (IEA,ISO)
cardiac neural crest cell migration involved in outflow tract morphogenesis  (IEA,ISO)
cellular response to follicle-stimulating hormone stimulus  (IEA,ISO)
cellular response to human chorionic gonadotropin stimulus  (IEA,ISO)
cellular response to luteinizing hormone stimulus  (IEA,ISO)
cellular response to mechanical stimulus  (IMP)
cellular response to oxidative stress  (IEA,ISO)
cranial skeletal system development  (IEA,ISO)
developmental pigmentation  (IBA)
embryonic heart tube development  (IEA,ISO)
embryonic skeletal system development  (IEA,ISO)
endothelin receptor signaling pathway  (IBA,IEA,ISO)
endothelin receptor signaling pathway involved in heart process  (IEA,ISO)
enteric nervous system development  (IEA)
establishment of endothelial barrier  (IEA,ISO)
face development  (IEA,ISO)
fibroblast proliferation  (IMP)
gene expression  (IEA,ISO)
glomerular endothelium development  (IEA,ISO)
glomerular filtration  (IEA,IMP,ISO)
glomerulus development  (ISO)
head development  (ISO)
heart development  (ISO)
heart process  (ISO)
heparin metabolic process  (IEA,ISO)
histamine secretion  (IMP)
in utero embryonic development  (IEA,ISO)
intracellular calcium ion homeostasis  (IEA,ISO)
left ventricular cardiac muscle tissue morphogenesis  (IEA,ISO)
maternal process involved in parturition  (IEP)
meiotic cell cycle process involved in oocyte maturation  (IEA,ISO)
mesenchymal cell apoptotic process  (IEA,ISO)
middle ear morphogenesis  (IEA,ISO)
mitochondrion organization  (IEA,ISO)
mitotic cell cycle  (IEA,ISO)
negative regulation of apoptotic process  (IMP)
neural crest cell development  (ISO)
neural crest cell differentiation  (ISO)
neural crest cell fate commitment  (IEA,ISO)
neuromuscular process  (IEA,ISO)
neuron projection development  (ISO)
neuron remodeling  (IEA,ISO)
noradrenergic neuron differentiation  (IEA,ISO)
norepinephrine metabolic process  (IEA,ISO)
pharyngeal arch artery morphogenesis  (IEA,ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
podocyte apoptotic process  (IEA,ISO)
podocyte differentiation  (IEA,ISO)
positive regulation of calcium ion transport  (IMP)
positive regulation of canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cytosolic calcium ion concentration  (IDA)
positive regulation of ERK1 and ERK2 cascade  (IMP)
positive regulation of kidney development  (IMP)
positive regulation of neutrophil chemotaxis  (IMP)
positive regulation of odontogenesis  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of release of sequestered calcium ion into cytosol  (IMP)
protein kinase A signaling  (IEA,ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (IMP)
protein transmembrane transport  (IEA,ISO)
regulation of blood pressure  (IEA,ISO)
regulation of epithelial cell proliferation  (IMP)
regulation of glucose transmembrane transport  (IEA,ISO)
regulation of heart rate  (IEA,ISO)
regulation of protein localization to cell leading edge  (IEA,ISO)
renal albumin absorption  (IEA,ISO)
renal sodium ion absorption  (IEA,ISO)
respiratory gaseous exchange by respiratory system  (IEA,ISO)
response to acetylcholine  (IEA,ISO)
response to amphetamine  (IEA,ISO)
response to hypoxia  (IEA,ISO)
response to lipopolysaccharide  (IMP)
response to organic cyclic compound  (IEP)
response to wounding  (IEA,ISO)
Rho protein signal transduction  (IMP)
semaphorin-plexin signaling pathway involved in axon guidance  (IEA,ISO)
smooth muscle cell proliferation  (IMP)
sodium ion homeostasis  (IEA,ISO)
sympathetic nervous system development  (IEA,ISO)
sympathetic neuron axon guidance  (IEA,ISO)
thyroid gland development  (IEA,ISO)
vascular associated smooth muscle cell development  (IEA,ISO)
vasoconstriction  (IBA,IEA,IMP,ISO)

Cellular Component

Molecular Function
endothelin receptor activity  (IBA,IDA,IEA,ISO,TAS)
protein binding  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
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2. Inhibition of endothelin-1 receptors improves impaired nitric oxide synthase-dependent dilation of cerebral arterioles in type-1 diabetic rats. Arrick DM and Mayhan WG, Microcirculation. 2010 Aug;17(6):439-46.
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40. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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44. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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49. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
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51. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
52. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
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57. GOA pipeline RGD automated data pipeline
58. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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69. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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Additional References at PubMed
PMID:1312429   PMID:8982507   PMID:9449664   PMID:9826706   PMID:10626068   PMID:11546805   PMID:11882629   PMID:11897624   PMID:11910302   PMID:12464391   PMID:12668144   PMID:12686728  
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PMID:21801594   PMID:21801595   PMID:22258095   PMID:22365956   PMID:22406300   PMID:22407503   PMID:22569294   PMID:22952915   PMID:23047940   PMID:23351051   PMID:23396520   PMID:23436727  
PMID:23946290   PMID:24144054   PMID:24157978   PMID:24449761   PMID:24486390   PMID:24582810   PMID:24636620   PMID:24815227   PMID:24918345   PMID:25088996   PMID:25091502   PMID:25255392  
PMID:25891848   PMID:26459423   PMID:26528589   PMID:26776836   PMID:27697218   PMID:27997891   PMID:28012855   PMID:28412414   PMID:28579512   PMID:28757442   PMID:29329779   PMID:29360807  
PMID:31075232   PMID:31398465   PMID:32023824   PMID:33098940   PMID:33127751   PMID:33339902   PMID:34894846   PMID:38166688  


Genomics

Comparative Map Data
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81947,137,360 - 47,207,961 (+)NCBIGRCr8mRatBN7.21930,233,540 - 30,303,727 (+)NCBImRatBN7.2mRatBN7.2mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblmRatBN7.2 EnsemblUTH_Rnor_SHR_Utx1937,065,939 - 37,130,121 (+)NCBIRnor_SHRUTH_Rnor_SHR_UtxUTH_Rnor_SHRSP_BbbUtx_1.01937,719,814 - 37,783,991 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_WKY_Bbb_1.01939,968,901 - 40,033,091 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4RGSC_v3.11932,051,058 - 32,110,066 (+)NCBICelera1929,719,589 - 29,778,843 (+)NCBICeleraCytogenetic Map19q11NCBI
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38GRCh38.p14 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38GRCh374148,402,249 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37Build 364148,621,575 - 148,685,555 (+)NCBINCBI36Build 36hg18NCBI36Build 344148,759,734 - 148,823,710NCBICelera4145,723,204 - 145,787,202 (+)NCBICeleraCytogenetic Map4q31.22-q31.23NCBIHuRef4144,129,326 - 144,193,179 (+)NCBIHuRefCHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1T2T-CHM13v2.04150,805,228 - 150,869,037 (+)NCBIT2T-CHM13v2.0
Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBIGRCm39GRCm39mm39GRCm39 Ensembl878,389,660 - 78,451,093 (-)EnsemblGRCm39 EnsemblGRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37MGSCv37mm9NCBIm37MGSCv36880,559,140 - 80,620,420 (-)NCBIMGSCv36mm8Celera881,946,457 - 82,007,225 (-)NCBICeleraCytogenetic Map8C1NCBIcM Map836.63NCBI
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23145,349,200 - 145,415,071 (+)NCBINHGRI_mPanPan1-v2NHGRI_mPanPan14145,714,744 - 145,780,615 (+)NCBINHGRI_mPanPan1Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1Dog10K_Boxer_Tasha1546,219,878 - 46,270,714 (+)NCBIDog10K_Boxer_TashaROS_Cfam_1.01546,496,528 - 46,553,179 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0 Ensembl1546,496,502 - 46,554,470 (+)EnsemblROS_Cfam_1.0 EnsemblUMICH_Zoey_3.11545,768,959 - 45,819,737 (+)NCBIUMICH_Zoey_3.1UNSW_CanFamBas_1.01545,864,678 - 45,915,481 (+)NCBIUNSW_CanFamBas_1.0UU_Cfam_GSD_1.01546,175,034 - 46,225,816 (+)NCBIUU_Cfam_GSD_1.0
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530144,512,782 - 44,568,451 (-)NCBIHiC_Itri_2SpeTri2.0 EnsemblNW_0049365351,949,941 - 2,005,910 (-)EnsemblSpeTri2.0SpeTri2.0 EnsemblSpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBIChlSab1.1ChlSab1.1chlSab2ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2Vero_WHO_p1.0NW_02366603773,678,428 - 73,748,330 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ednra
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248536,302,751 - 6,360,089 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2HetGla 1.0NW_0046248536,298,406 - 6,362,353 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
Variants

.
Variants in Ednra
518 total Variants
miRNA Target Status

Predicted Target Of
Summary ValueCount of predictions:386Count of miRNA genes:211Interacting mature miRNAs:276Transcripts:ENSRNOT00000058162Prediction methods:Miranda, TargetscanResult types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat61407Scl12Serum cholesterol level QTL 120.001blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)191392640130303727Rat1558656Prcs1Prostate cancer susceptibility QTL 15prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)191511459834521833Rat7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191545586057337602Rat1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191560502346559041Rat1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191563020157337602Rat2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)191715443357337602Rat61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192048357557337602Rat61328Eae8Experimental allergic encephalomyelitis QTL 84nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)192481604133061905Rat1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192481797839654489Rat1354600Salc2Saline consumption QTL 29.910.001drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)192753020737947399Rat1354607Gmadr1Adrenal mass QTL 15.83adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)192753020737947399Rat1354633Bw28Body weight QTL 286.04body mass (VT:0001259)body weight (CMO:0000012)192753020737947399Rat724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)192932249057337602Rat
Markers in Region
D19Mco2  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01944,873,858 - 44,874,084NCBIRnor5.0RGSC_v3.41932,107,108 - 32,107,333RGDRGSC3.4RGSC_v3.11932,111,934 - 32,112,159RGDCytogenetic Map19q11UniSTS
RH127903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,296,755 - 30,296,970 (+)MAPPERmRatBN7.2Rnor_6.01933,991,410 - 33,991,624NCBIRnor6.0Rnor_5.01944,874,611 - 44,874,825UniSTSRnor5.0RGSC_v3.41932,107,860 - 32,108,074UniSTSRGSC3.4Celera1929,778,550 - 29,778,764UniSTSCytogenetic Map19q11UniSTS
RH141089  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21930,295,676 - 30,295,891 (+)MAPPERmRatBN7.2Rnor_6.01933,990,331 - 33,990,545NCBIRnor6.0Rnor_5.01944,873,532 - 44,873,746UniSTSRnor5.0RGSC_v3.41932,106,781 - 32,106,995UniSTSRGSC3.4Celera1929,777,471 - 29,777,685UniSTSRH 3.4 Map19231.2UniSTSCytogenetic Map19q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 37 6 20 37 11
Low 3 6 57 41 19 41 8 11 68 15 4 8
Below cutoff
View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772472 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039097468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005496613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CB798671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ832324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ839232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ839233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ839234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M60786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000058162   &xrArr;   ENSRNOP00000054967
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,233,692 - 30,297,049 (+)EnsemblRnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078395   &xrArr;   ENSRNOP00000072294
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,237,576 - 30,294,075 (+)EnsemblRnor_6.0 Ensembl1933,932,532 - 33,988,729 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000078701   &xrArr;   ENSRNOP00000069839
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,237,576 - 30,294,075 (+)EnsemblRnor_6.0 Ensembl1933,932,532 - 33,988,729 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080095   &xrArr;   ENSRNOP00000071866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1933,931,719 - 33,988,877 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000080317   &xrArr;   ENSRNOP00000071667
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,233,571 - 30,297,049 (+)EnsemblRnor_6.0 Ensembl1933,932,558 - 33,988,196 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000091985   &xrArr;   ENSRNOP00000073963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1930,237,576 - 30,294,075 (+)EnsemblRnor_6.0 Ensembl1933,932,532 - 33,988,729 (+)Ensembl
RefSeq Acc Id: NM_012550   &xrArr;   NP_036682
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,137,924 - 47,201,285 (+)NCBImRatBN7.21930,233,692 - 30,297,049 (+)NCBIRnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor_5.01944,812,252 - 44,874,904 (+)NCBIRGSC_v3.41932,042,366 - 32,108,153 (+)RGDCelera1929,719,589 - 29,778,843 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097468   &xrArr;   XP_038953396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,137,360 - 47,201,285 (+)NCBImRatBN7.21930,233,540 - 30,293,865 (+)NCBI
RefSeq Acc Id: XR_005496613
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81947,137,360 - 47,207,961 (+)NCBImRatBN7.21930,233,543 - 30,303,727 (+)NCBI
Protein Sequences
Protein RefSeqs NP_036682 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953396 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41114 (Get FASTA)   NCBI Sequence Viewer  
  ABH10615 (Get FASTA)   NCBI Sequence Viewer  
  ABI33934 (Get FASTA)   NCBI Sequence Viewer  
  ABI33935 (Get FASTA)   NCBI Sequence Viewer  
  ABI33936 (Get FASTA)   NCBI Sequence Viewer  
  EDL92330 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054967
  ENSRNOP00000054967.2
  ENSRNOP00000069839.1
  ENSRNOP00000071667.2
  ENSRNOP00000072294.1
  ENSRNOP00000073963.1
  ENSRNOP00055011058
  ENSRNOP00060017028
  ENSRNOP00065012929
GenBank Protein P26684 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_036682   &xlArr;   NM_012550
- Peptide Label: precursor
- UniProtKB: P26684 (UniProtKB/Swiss-Prot),   A0A0G2JSX5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071667   &xlArr;   ENSRNOT00000080317
RefSeq Acc Id: ENSRNOP00000071866   &xlArr;   ENSRNOT00000080095
RefSeq Acc Id: ENSRNOP00000072294   &xlArr;   ENSRNOT00000078395
RefSeq Acc Id: ENSRNOP00000054967   &xlArr;   ENSRNOT00000058162
RefSeq Acc Id: ENSRNOP00000073963   &xlArr;   ENSRNOT00000091985
RefSeq Acc Id: ENSRNOP00000069839   &xlArr;   ENSRNOT00000078701
RefSeq Acc Id: XP_038953396   &xlArr;   XM_039097468
- Peptide Label: isoform X1
- UniProtKB: P26684 (UniProtKB/Swiss-Prot),   A1Y2B8 (UniProtKB/TrEMBL)
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P26684-F1-model_v2 AlphaFold P26684 1-426 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2535 AgrOrtholog
BioCyc Gene G2FUF-5916 BioCyc
Ensembl Genes ENSRNOG00000012721 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055008127 UniProtKB/Swiss-Prot
  ENSRNOG00060012663 UniProtKB/Swiss-Prot
  ENSRNOG00065010420 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000058162 ENTREZGENE
  ENSRNOT00000058162.4 UniProtKB/TrEMBL
  ENSRNOT00000078395.2 UniProtKB/TrEMBL
  ENSRNOT00000078701.2 UniProtKB/TrEMBL
  ENSRNOT00000080317.2 UniProtKB/TrEMBL
  ENSRNOT00000091985.2 UniProtKB/TrEMBL
  ENSRNOT00055013770 UniProtKB/Swiss-Prot
  ENSRNOT00060021549 UniProtKB/Swiss-Prot
  ENSRNOT00065016885 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Endthln_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ETA_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24326 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24326 ENTREZGENE
PANTHER ENDOTHELIN-1 RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ednra PhenoGen
PRINTS ENDOTHELINAR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENDOTHELINR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012721 RatGTEx
  ENSRNOG00055008127 RatGTEx
  ENSRNOG00060012663 RatGTEx
  ENSRNOG00065010420 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC215722
UniProt A0A0G2JSX5 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K118_RAT UniProtKB/TrEMBL
  A1Y2B8 ENTREZGENE, UniProtKB/TrEMBL
  A1Y2R7_RAT UniProtKB/TrEMBL
  A1Y2R8_RAT UniProtKB/TrEMBL
  A1Y2R9_RAT UniProtKB/TrEMBL
  A6IYK2_RAT UniProtKB/TrEMBL
  EDNRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-03-29 Ednra  endothelin receptor type A  LOC100366209  endothelin-1 receptor-like  Data merged from RGD:2324049 737654 PROVISIONAL
2013-03-29 Ednra  endothelin receptor type A  RGD1559432  RGD1559432  Data merged from RGD:1559432 737654 PROVISIONAL
2010-05-06 LOC100366209  endothelin-1 receptor-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-04-30 RGD1559432  RGD1559432   RGD1559432_predicted  RGD1559432 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1559432_predicted  RGD1559432 (predicted)  LOC498937  LOC498937  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498937  LOC498937      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Ednra  Endothelin receptor type A      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in vascular and nonvascular tissues 628459
gene_expression expressed in vascular and nonvascular tissues 628515
gene_expression expressed in vascular and nonvascular tissues 628516
gene_expression not expressed in Spontaneously hypertensive rat hearts but was expressed in salt-hypertensive sensitive and resistant rats fed a high-salt diet 1358986
gene_product member of the endothelian family 628516
 


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