Pgr (progesterone receptor) - Rat Genome Database

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Gene: Pgr (progesterone receptor) Rattus norvegicus
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Symbol: Pgr
Name: progesterone receptor
RGD ID: 3317
Description: Enables several functions, including nuclear steroid receptor activity; sequence-specific DNA binding activity; and steroid binding activity. Involved in several processes, including cellular response to estrogen stimulus; cellular response to gonadotropin stimulus; and regulation of DNA-templated transcription. Located in axon terminus; dendritic spine; and perikaryon. Biomarker of endometriosis and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in endometriosis; hyperprolactinemia; and obesity. Orthologous to human PGR (progesterone receptor); PARTICIPATES IN phosphatidylinositol 3-kinase-Akt signaling pathway; INTERACTS WITH (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: nuclear receptor subfamily 3 group C member 3; PR; progestin receptor form A; progestin receptor form B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Pgrem1Soar  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8814,354,398 - 14,413,271 (+)NCBIGRCr8mRatBN7.286,072,673 - 6,131,552 (+)NCBImRatBN7.2mRatBN7.2mRatBN7.2 Ensembl86,072,673 - 6,131,344 (+)EnsemblmRatBN7.2 EnsemblUTH_Rnor_SHR_Utx810,003,167 - 10,062,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_UtxUTH_Rnor_SHRSP_BbbUtx_1.088,300,792 - 8,359,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_WKY_Bbb_1.086,329,892 - 6,388,768 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0Rnor_6.087,128,656 - 7,187,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0Rnor_6.0 Ensembl87,128,656 - 7,187,796 (+)EnsemblRnor6.0rn6Rnor6.0Rnor_5.087,113,895 - 7,172,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0RGSC_v3.485,784,717 - 5,845,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4RGSC_v3.185,784,716 - 5,845,901 (+)NCBICelera87,609,728 - 7,668,047 (+)NCBICeleraCytogenetic Map8q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
PgrRatBrain Injuries  IEP 7248711 RGD 
PgrRatductal carcinoma in situ disease_progressionISOPGR (Homo sapiens)2289659 RGD 
PgrRatendometriosis  ISOPGR (Homo sapiens)1601277 RGD 
PgrRatendometriosis  IEP 7248704 RGD 
PgrRathyperprolactinemia susceptibilityISOPGR (Homo sapiens)1601278 RGD 
PgrRatleiomyoma no_associationISOPGR (Homo sapiens)1601278 RGD 
PgrRatobesity  ISOPGR (Homo sapiens)1642050 RGD 
PgrRatpolycystic ovary syndrome  IEP 4145934protein:decreased expression:ovary:RGD 

Imported Disease Annotations - ClinVar

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
PgrRatataxia telangiectasia  ISOPGR (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571 more ...
PgrRatintellectual disability  ISOPGR (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

Imported Disease Annotations - CTD

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PgrRatadenocarcinoma  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15639718PgrRatAnimal Mammary Neoplasms  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15637090PgrRatBreast Neoplasms  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19436038 and PMID:21501481PgrRatcarcinoma  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15637090PgrRatEndometrial Neoplasms  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23200943PgrRatendometriosis  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642 and PMID:21232532PgrRatExperimental Mammary Neoplasms  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15637090PgrRatmeningioma  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8008172 more ...PgrRatMesothelioma  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15639718PgrRatProgesterone Resistance  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD PgrRatRecurrence  ISOPGR (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19747051

Imported Disease Annotations - OMIM

Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PgrRatProgesterone Resistance  ISOPGR (Homo sapiens)7240710 OMIM 

Gene-Chemical Interaction Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PgrRat(-)-epigallocatechin 3-gallate decreases expressionISOPGR (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of PGR mRNACTDPMID:20706672PgrRat(-)-epigallocatechin 3-gallate increases expressionISOPgr (Mus musculus)6480464epigallocatechin gallate results in increased expression of PGR proteinCTDPMID:35863485PgrRat(20S)-ginsenoside Rh1 increases expressionISOPGR (Homo sapiens)6480464ginsenoside Rh1 results in increased expression of PGR proteinCTDPMID:16204943PgrRat(25R)-cholest-5-ene-3beta,26-diol increases expressionISOPGR (Homo sapiens)648046427-hydroxycholesterol results in increased expression of PGR mRNA and 27-hydroxycholesterol results in increased expression of PGR proteinCTDPMID:17872378PgrRat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]CTDPMID:17872378PgrRat(R)-camphor multiple interactionsISOPGR (Homo sapiens)6480464Camphor binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRat(R)-linalyl acetate increases expressionISOPGR (Homo sapiens)6480464linalyl acetate results in increased expression of PGR mRNACTDPMID:31393563PgrRat(R)-linalyl acetate multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of PGR mRNA]CTDPMID:31393563PgrRat(S)-naringenin increases expressionEXP 6480464naringenin results in increased expression of PGR mRNACTDPMID:10397250PgrRat(S)-naringenin multiple interactionsISOPGR (Homo sapiens)6480464[naringenin results in increased phosphorylation of and results in increased activity of ESR1 protein] which results in increased expression of PGR mRNACTDPMID:24586459PgrRat(S)-nicotine decreases expressionISOPGR (Homo sapiens)6480464Nicotine results in decreased expression of PGR mRNACTDPMID:27552315PgrRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsEXP 64804642 more ...CTDPMID:19414516PgrRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expressionISOPGR (Homo sapiens)64804642 more ...CTDPMID:23384675PgrRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsISOPGR (Homo sapiens)6480464ESR1 protein inhibits the reaction [2 more ...CTDPMID:23384675PgrRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane increases expressionEXP 64804642 more ...CTDPMID:10774817PgrRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane multiple interactionsISOPgr (Mus musculus)6480464[Estradiol co-treated with 2 more ...CTDPMID:11509743PgrRat1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane decreases expressionISOPgr (Mus musculus)64804642 more ...CTDPMID:11509743PgrRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactionsEXP 6480464o and p'-DDT promotes the reaction [Progesterone binds to PGR protein]CTDPMID:7414049PgrRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionEXP 6480464o and p'-DDT results in decreased expression of PGR mRNACTDPMID:10822019 and PMID:23209616PgrRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOPgr (Mus musculus)6480464o and p'-DDT results in increased expression of PGR mRNACTDPMID:9607801PgrRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOPGR (Homo sapiens)6480464o and p'-DDT results in increased expression of PGR mRNACTDPMID:11867264 more ...PgrRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects bindingISOPGR (Homo sapiens)6480464o and p'-DDT binds to PGR proteinCTDPMID:14579009PgrRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactionsISOPGR (Homo sapiens)64804642-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o more ...CTDPMID:14579009 more ...PgrRat1,2-dichloroethane decreases expressionISOPgr (Mus musculus)6480464ethylene dichloride results in decreased expression of PGR mRNACTDPMID:28960355PgrRat1,2-dimethylhydrazine multiple interactionsEXP 6480464[APC protein affects the susceptibility to 1 and 2-Dimethylhydrazine] which results in increased expression of PGR mRNACTDPMID:27840820PgrRat1-(3-(trifluoromethyl)phenyl)piperazine increases expressionISOPGR (Homo sapiens)64804641-(3-trifluoromethylphenyl)piperazine results in increased expression of PGR mRNACTDPMID:23026265PgrRat1-benzylpiperazine increases expressionISOPGR (Homo sapiens)64804641-benzylpiperazine results in increased expression of PGR mRNACTDPMID:23026265PgrRat1-Hydroxypyrene multiple interactionsISOPGR (Homo sapiens)64804641-hydroxypyrene inhibits the reaction [Progesterone binds to PGR protein] and [Progesterone co-treated with 1-hydroxypyrene] results in decreased expression of PGR mRNACTDPMID:9144411PgrRat17alpha-ethynylestradiol increases expressionISOPgr (Mus musculus)6480464Ethinyl Estradiol results in increased expression of PGR mRNA and Ethinyl Estradiol results in increased expression of PGR proteinCTDPMID:17574608 more ...PgrRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of PGR mRNA and Ethinyl Estradiol results in increased expression of PGR proteinCTDPMID:10822019 more ...PgrRat17alpha-ethynylestradiol multiple interactionsISOPGR (Homo sapiens)6480464Ethinyl Estradiol binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRat17alpha-ethynylestradiol increases expressionISOPGR (Homo sapiens)6480464Ethinyl Estradiol results in increased expression of PGR mRNACTDPMID:18936297 and PMID:35307500PgrRat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of PGR mRNACTDPMID:16551644PgrRat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of PGR proteinCTDPMID:11218048PgrRat17alpha-ethynylestradiol multiple interactionsEXP 6480464[Ethinyl Estradiol co-treated with Progesterone] results in increased expression of PGR protein more ...CTDPMID:14728856 and PMID:19654335PgrRat17alpha-hydroxyprogesterone multiple interactionsISOPGR (Homo sapiens)648046417-alpha-Hydroxyprogesterone analog binds to and results in increased activity of PGR proteinCTDPMID:18060946PgrRat17beta-estradiol multiple interactionsISOPGR (Homo sapiens)64804642-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of PGR mRNA] more ...CTDPMID:10376965 more ...PgrRat17beta-estradiol increases expressionISOPGR (Homo sapiens)6480464Estradiol results in increased expression of PGR mRNA more ...CTDPMID:10376965 more ...PgrRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of PGR mRNA and Estradiol results in increased expression of PGR proteinCTDPMID:10397250 more ...PgrRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PGR mRNA and Estradiol results in decreased expression of PGR proteinCTDPMID:17532555 more ...PgrRat17beta-estradiol affects expressionISOPgr (Mus musculus)6480464Estradiol affects the expression of PGR mRNA and Estradiol affects the expression of PGR proteinCTDPMID:21195146 and PMID:23552522PgrRat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of PGR mRNA and Estradiol affects the expression of PGR proteinCTDPMID:18790044 more ...PgrRat17beta-estradiol multiple interactionsEXP 648046411-fluoro-7-(14 more ...CTDPMID:12834913 more ...PgrRat17beta-estradiol decreases expressionISOPGR (Homo sapiens)6480464Estradiol results in decreased expression of PGR mRNA alternative form and Estradiol results in decreased expression of PGR protein alternative formCTDPMID:15806153PgrRat17beta-estradiol multiple interactionsISOPgr (Mus musculus)6480464[Estradiol co-treated with 2 more ...CTDPMID:11145618 more ...PgrRat17beta-estradiol increases expressionISOPgr (Mus musculus)6480464Estradiol results in increased expression of PGR mRNA and Estradiol results in increased expression of PGR proteinCTDPMID:11145618 more ...PgrRat17beta-estradiol decreases expressionISOPgr (Mus musculus)6480464Estradiol results in decreased expression of PGR mRNACTDPMID:11509743 more ...PgrRat17beta-estradiol 3-benzoate increases expressionEXP 6480464estradiol 3-benzoate results in increased expression of PGR mRNA more ...CTDPMID:15456929 more ...PgrRat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one affects bindingISOPGR (Homo sapiens)6480464Metribolone binds to PGR proteinCTDPMID:15189034PgrRat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOPgr (Mus musculus)6480464[2 more ...CTDPMID:25510870PgrRat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOPGR (Homo sapiens)64804642 more ...CTDPMID:16601080 more ...PgrRat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISOPGR (Homo sapiens)64804642 more ...CTDPMID:30796839PgrRat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOPgr (Mus musculus)6480464[2 more ...CTDPMID:25510870PgrRat2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene multiple interactionsISOPGR (Homo sapiens)64804642 more ...CTDPMID:14579009 and PMID:18262749PgrRat2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene affects bindingISOPGR (Homo sapiens)64804642 more ...CTDPMID:14579009PgrRat2,3',4,4',5-Pentachlorobiphenyl multiple interactionsISOPGR (Homo sapiens)64804642 more ...CTDPMID:26022396PgrRat2,3,3',4,4',5,5'-Heptachlorobiphenyl multiple interactionsISOPGR (Homo sapiens)64804642 more ...CTDPMID:26022396PgrRat2,3,4,5-Tetrachloro-4'-biphenylol multiple interactionsISOPGR (Homo sapiens)64804644-hydroxy-2' more ...CTDPMID:9144411PgrRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPgr (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PGR mRNA and Tetrachlorodibenzodioxin results in decreased expression of PGR protein alternative formCTDPMID:17056225 more ...PgrRat2,3,7,8-tetrachlorodibenzodioxine increases response to substanceISOPGR (Homo sapiens)6480464PGR protein results in increased susceptibility to TetrachlorodibenzodioxinCTDPMID:22266097PgrRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPgr (Mus musculus)6480464Fish Oils inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PGR mRNA]CTDPMID:21653731PgrRat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPGR (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of PGR mRNA and Tetrachlorodibenzodioxin results in increased expression of PGR proteinCTDPMID:15570619 more ...PgrRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PGR mRNA and Tetrachlorodibenzodioxin results in increased expression of PGR proteinCTDPMID:11399792 more ...PgrRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464Estrogens affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PGR mRNA] and Estrogens affects the reaction [Tetrachlorodibenzodioxin results in increased expression of PGR protein]CTDPMID:15570619PgrRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPGR (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of PGR mRNA more ...CTDPMID:16009159 more ...PgrRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPGR (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PGR mRNA more ...CTDPMID:10822009 more ...PgrRat2,4,6-Trimethylbenzaldehyde multiple interactionsISOPGR (Homo sapiens)64804642 more ...CTDPMID:27633901PgrRat2,4-dibromophenyl 2,4,5-tribromophenyl ether multiple interactionsISOPGR (Homo sapiens)64804642 more ...CTDPMID:16601080 and PMID:23398518PgrRat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionEXP 64804642 more ...CTDPMID:16414171PgrRat2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester multiple interactionsISOPGR (Homo sapiens)6480464homosalate binds to and results in decreased activity of PGR proteinCTDPMID:15537743PgrRat2-palmitoylglycerol increases expressionISOPGR (Homo sapiens)64804642-palmitoylglycerol results in increased expression of PGR mRNACTDPMID:37199045PgrRat26-hydroxycholesterol multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [27-hydroxycholesterol results in increased expression of PGR mRNA]CTDPMID:17872378PgrRat26-hydroxycholesterol increases expressionISOPGR (Homo sapiens)648046427-hydroxycholesterol results in increased expression of PGR mRNA and 27-hydroxycholesterol results in increased expression of PGR proteinCTDPMID:17872378PgrRat3',5'-cyclic AMP multiple interactionsISOPGR (Homo sapiens)6480464Cyclic AMP inhibits the reaction [[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]CTDPMID:37552060PgrRat3,3',4,4',5-pentachlorobiphenyl multiple interactionsISOPGR (Homo sapiens)64804643 more ...CTDPMID:26022396PgrRat3,3',5,5'-tetrabromobisphenol A increases expressionISOPGR (Homo sapiens)6480464tetrabromobisphenol A results in increased expression of PGR proteinCTDPMID:11693576 and PMID:12753421PgrRat3,3',5,5'-tetrabromobisphenol A multiple interactionsISOPGR (Homo sapiens)6480464tetrabromobisphenol A binds to and results in decreased activity of PGR proteinCTDPMID:23398518PgrRat3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol increases expressionISOPGR (Homo sapiens)6480464fluorotelomer alcohols results in increased expression of PGR mRNACTDPMID:16393665PgrRat3,5-di-tert-Butyl-4-hydroxybenzaldehyde multiple interactionsISOPGR (Homo sapiens)64804643 and 5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRat3,6-diaminoacridine multiple interactionsISOPGR (Homo sapiens)6480464Proflavine inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRat3,7-dihydropurine-6-thione increases expressionEXP 6480464Mercaptopurine results in increased expression of PGR mRNACTDPMID:23358152PgrRat3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione multiple interactionsISOPGR (Homo sapiens)6480464bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [benz(a)anthracene results in increased expression of PGR mRNA]]CTDPMID:22643241PgrRat3-methylcholanthrene increases expressionISOPGR (Homo sapiens)6480464Methylcholanthrene results in increased expression of PGR mRNACTDPMID:16257430PgrRat3-methylcholanthrene multiple interactionsEXP 6480464Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of PGR mRNA] and Methylcholanthrene inhibits the reaction [Estradiol results in increased expression of PGR protein]CTDPMID:26372666PgrRat3-methylcholanthrene increases expressionEXP 6480464Methylcholanthrene results in increased expression of PGR mRNACTDPMID:26372666PgrRat4'-epidoxorubicin multiple interactionsISOPGR (Homo sapiens)6480464Epirubicin binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRat4,4'-sulfonyldiphenol increases expressionISOPGR (Homo sapiens)6480464bisphenol S results in increased expression of PGR mRNA and bisphenol S results in increased expression of PGR proteinCTDPMID:28591870 more ...PgrRat4,4'-sulfonyldiphenol increases expressionISOPgr (Mus musculus)6480464bisphenol S results in increased expression of PGR proteinCTDPMID:29526645PgrRat4,4'-sulfonyldiphenol multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [bisphenol S results in increased expression of PGR mRNA]CTDPMID:29389661 and PMID:34831106PgrRat4-hydroxy-17beta-estradiol increases expressionISOPgr (Mus musculus)64804644-hydroxyestradiol results in increased expression of PGR mRNACTDPMID:9607801PgrRat4-nonylphenol increases expressionISOPGR (Homo sapiens)64804644-nonylphenol results in increased expression of PGR mRNACTDPMID:16393665PgrRat4-nonylphenol decreases expressionISOPgr (Mus musculus)64804644-nonylphenol analog results in decreased expression of PGR mRNACTDPMID:27086933PgrRat4-nonylphenol increases expressionEXP 64804644-nonylphenol results in increased expression of PGR mRNACTDPMID:17033158PgrRat4-terpineol multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [terpinenol-4 results in increased expression of PGR mRNA]CTDPMID:31393563PgrRat4-terpineol increases expressionISOPGR (Homo sapiens)6480464terpinenol-4 results in increased expression of PGR mRNACTDPMID:31393563PgrRat4-tert-butylphenol increases expressionISOPGR (Homo sapiens)6480464butylphen results in increased expression of PGR proteinCTDPMID:11879974PgrRat4-tert-Octylphenol increases expressionEXP 64804644-tert-octylphenol results in increased expression of PGR mRNACTDPMID:14763995 and PMID:17033158PgrRat4-tert-Octylphenol increases expressionISOPGR (Homo sapiens)64804644-tert-octylphenol results in increased expression of PGR mRNACTDPMID:35307500PgrRat4-tert-Octylphenol decreases expressionISOPgr (Mus musculus)64804644-tert-octylphenol results in decreased expression of PGR mRNACTDPMID:30061528PgrRat5-aza-2'-deoxycytidine increases expressionISOPGR (Homo sapiens)6480464Decitabine results in increased expression of PGR mRNA more ...CTDPMID:16024066 and PMID:21515334PgrRat5-aza-2'-deoxycytidine multiple interactionsISOPGR (Homo sapiens)6480464[Decitabine co-treated with trichostatin A] affects the expression of PGR mRNA more ...CTDPMID:16024066 more ...PgrRat5-fluorouracil affects expressionISOPGR (Homo sapiens)6480464Fluorouracil affects the expression of PGR mRNACTDPMID:34151400PgrRat6-oxocampestanol affects localizationISOPGR (Homo sapiens)64804646-oxocampestanol affects the localization of PGR proteinCTDPMID:32001316PgrRat8-Br-cAMP multiple interactionsISOPGR (Homo sapiens)6480464[8-Bromo Cyclic Adenosine Monophosphate co-treated with Progesterone co-treated with Estradiol] affects the expression of and affects the phosphorylation of PGR proteinCTDPMID:23275455PgrRat8-Br-cAMP decreases expressionISOPGR (Homo sapiens)64804648-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PGR proteinCTDPMID:23275455PgrRatadefovir pivoxil multiple interactionsISOPGR (Homo sapiens)6480464adefovir dipivoxil binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatafimoxifene multiple interactionsISOPGR (Homo sapiens)6480464[Resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA] more ...CTDPMID:27159275 more ...PgrRatafimoxifene multiple interactionsISOPgr (Mus musculus)6480464afimoxifene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:26879975PgrRatafimoxifene increases expressionISOPGR (Homo sapiens)6480464afimoxifene results in increased expression of PGR mRNACTDPMID:15072547PgrRatafimoxifene decreases expressionISOPGR (Homo sapiens)6480464afimoxifene results in decreased expression of PGR mRNACTDPMID:27159275PgrRatalachlor multiple interactionsISOPGR (Homo sapiens)6480464alachlor inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRatalachlor affects bindingISOPGR (Homo sapiens)6480464alachlor binds to PGR proteinCTDPMID:14579009PgrRataldicarb multiple interactionsISOPGR (Homo sapiens)6480464Aldicarb inhibits the reaction [Progesterone results in increased activity of PGR protein]CTDPMID:9126867PgrRataldrin multiple interactionsISOPGR (Homo sapiens)6480464Aldrin inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 more ...CTDPMID:14579009 and PMID:26022396PgrRataldrin affects bindingISOPGR (Homo sapiens)6480464Aldrin binds to PGR proteinCTDPMID:14579009PgrRatall-trans-retinoic acid increases expressionISOPGR (Homo sapiens)6480464Tretinoin results in increased expression of PGRCTDPMID:11029503PgrRatalpha-hexachlorocyclohexane multiple interactionsISOPGR (Homo sapiens)6480464alpha-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatalpha-Methylstyrene multiple interactionsISOPGR (Homo sapiens)6480464alpha-methylstyrol binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatalpha-naphthoflavone increases expressionISOPGR (Homo sapiens)6480464alpha-naphthoflavone results in increased expression of PGR proteinCTDPMID:22266097PgrRatalpha-Zearalanol increases expressionISOPgr (Mus musculus)6480464Zeranol results in increased expression of PGR mRNACTDPMID:24120472PgrRatalpha-Zearalanol multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PGR mRNACTDPMID:35163327PgrRatalpha-Zearalanol affects expressionEXP 6480464Zeranol affects the expression of PGR proteinCTDPMID:35163327PgrRatalternariol multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [alternariol results in increased expression of PGR protein]CTDPMID:23665424PgrRatalternariol increases expressionISOPGR (Homo sapiens)6480464alternariol results in increased expression of PGR proteinCTDPMID:23665424PgrRataminoglutethimide multiple interactionsISOPGR (Homo sapiens)6480464[Aminoglutethimide co-treated with 17 alpha-Hydroxyprogesterone Caproate] results in decreased expression of PGR proteinCTDPMID:8565696PgrRataminoglutethimide decreases expressionISOPGR (Homo sapiens)6480464Aminoglutethimide results in decreased expression of PGR proteinCTDPMID:8565696 and PMID:9208491PgrRatamlodipine multiple interactionsISOPGR (Homo sapiens)6480464Amlodipine binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatammonium sulfate increases activityISOPGR (Homo sapiens)6480464Ammonium Sulfate results in increased activity of PGR proteinCTDPMID:9879984PgrRatamsacrine multiple interactionsISOPGR (Homo sapiens)6480464Amsacrine binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatanastrozole decreases expressionISOPGR (Homo sapiens)6480464anastrozole results in decreased expression of PGR proteinCTDPMID:16002280PgrRatandrogen antagonist multiple interactionsEXP 6480464[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatapigenin affects bindingISOPGR (Homo sapiens)6480464Apigenin binds to PGR proteinCTDPMID:14579009PgrRatapigenin multiple interactionsISOPGR (Homo sapiens)6480464Apigenin inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRataprepitant multiple interactionsISOPGR (Homo sapiens)6480464aprepitant binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatarsane multiple interactionsISOPGR (Homo sapiens)6480464[Metals more ...CTDPMID:29111618 and PMID:33047385PgrRatarsane decreases expressionISOPGR (Homo sapiens)6480464Arsenic results in decreased expression of PGR protein and Arsenic results in decreased expression of PGR protein alternative formCTDPMID:33047385PgrRatarsane affects expressionISOPGR (Homo sapiens)6480464Arsenic affects the expression of PGR mRNACTDPMID:33047385PgrRatarsenic atom multiple interactionsISOPGR (Homo sapiens)6480464[Metals more ...CTDPMID:29111618 and PMID:33047385PgrRatarsenic atom decreases expressionISOPGR (Homo sapiens)6480464Arsenic results in decreased expression of PGR protein and Arsenic results in decreased expression of PGR protein alternative formCTDPMID:33047385PgrRatarsenic atom affects expressionISOPGR (Homo sapiens)6480464Arsenic affects the expression of PGR mRNACTDPMID:33047385PgrRatarsenite(3-) increases expressionISOPGR (Homo sapiens)6480464arsenite results in increased expression of PGR mRNA and arsenite results in increased expression of PGR proteinCTDPMID:11014213 and PMID:31646340PgrRatarsenite(3-) increases methylationISOPGR (Homo sapiens)6480464arsenite results in increased methylation of PGR promoterCTDPMID:23974009PgrRatarsenite(3-) multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [arsenite results in increased expression of PGR mRNA] and Fulvestrant inhibits the reaction [arsenite results in increased expression of PGR protein]CTDPMID:11014213 and PMID:31646340PgrRatartesunate multiple interactionsISOPGR (Homo sapiens)6480464artesunate binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatatrazine multiple interactionsEXP 6480464[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA] more ...CTDPMID:23583632 and PMID:8812239PgrRatatrazine affects methylationEXP 6480464Atrazine affects the methylation of PGR geneCTDPMID:35440735PgrRatatrazine multiple interactionsISOPGR (Homo sapiens)6480464Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of PGR mRNA]CTDPMID:26923738PgrRatbendiocarb multiple interactionsISOPGR (Homo sapiens)6480464bendiocarb inhibits the reaction [Progesterone results in increased activity of PGR protein]CTDPMID:9126867PgrRatbenzo[a]pyrene multiple interactionsISOPGR (Homo sapiens)6480464Benzo(a)pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 more ...CTDPMID:10822009 and PMID:26022396PgrRatbenzo[a]pyrene increases methylationISOPGR (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of PGR exon and Benzo(a)pyrene results in increased methylation of PGR promoterCTDPMID:27901495PgrRatbeta-hexachlorocyclohexane multiple interactionsISOPGR (Homo sapiens)64804642-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA] more ...CTDPMID:16242299 more ...PgrRatbeta-hexachlorocyclohexane increases expressionISOPGR (Homo sapiens)6480464beta-hexachlorocyclohexane results in increased expression of PGR and beta-hexachlorocyclohexane results in increased expression of PGR mRNACTDPMID:16242299 more ...PgrRatbexarotene multiple interactionsISOPGR (Homo sapiens)6480464bexarotene binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatbicalutamide multiple interactionsISOPGR (Homo sapiens)6480464bicalutamide binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatbifenthrin multiple interactionsEXP 6480464bifenthrin inhibits the reaction [CGA protein results in increased expression of PGR mRNA]CTDPMID:21251947PgrRatbifenthrin multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [bifenthrin results in increased expression of PGR mRNA]CTDPMID:24938463PgrRatbifenthrin increases expressionISOPGR (Homo sapiens)6480464bifenthrin results in increased expression of PGR and bifenthrin results in increased expression of PGR mRNACTDPMID:24938463PgrRatbiochanin A affects bindingISOPGR (Homo sapiens)6480464biochanin A binds to PGR proteinCTDPMID:14579009PgrRatbiochanin A increases expressionEXP 6480464biochanin A results in increased expression of PGR mRNACTDPMID:34848279PgrRatbiochanin A multiple interactionsEXP 6480464Fulvestrant inhibits the reaction [biochanin A results in increased expression of PGR mRNA]CTDPMID:34848279PgrRatbiochanin A increases expressionISOPGR (Homo sapiens)6480464biochanin A results in increased expression of PGR mRNACTDPMID:16076101PgrRatbiochanin A multiple interactionsISOPGR (Homo sapiens)6480464biochanin A inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRatbiphenyl-2-ol increases expressionISOPGR (Homo sapiens)64804642-phenylphenol results in increased expression of PGR mRNACTDPMID:12822488PgrRatbiphenyl-4-ol increases expressionISOPGR (Homo sapiens)64804644-phenylphenol results in increased expression of PGR proteinCTDPMID:12753421PgrRatbis(2-ethylhexyl) phthalate multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatbis(2-ethylhexyl) phthalate multiple interactionsISOPGR (Homo sapiens)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA] and Cyclic AMP inhibits the reaction [[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]CTDPMID:37552060PgrRatbis(2-ethylhexyl) phthalate decreases expressionEXP 6480464Diethylhexyl Phthalate results in decreased expression of PGR proteinCTDPMID:36435455PgrRatbis(2-ethylhexyl) phthalate multiple interactionsISOPgr (Mus musculus)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the reaction [CGA protein results in increased expression of PGR mRNA]CTDPMID:33316053PgrRatbis(2-ethylhexyl) phthalate decreases expressionISOPgr (Mus musculus)6480464Diethylhexyl Phthalate results in decreased expression of PGR mRNACTDPMID:28286118PgrRatbisphenol A multiple interactionsISOPGR (Homo sapiens)6480464[bisphenol A co-treated with Tamoxifen] results in increased expression of PGR mRNA more ...CTDPMID:10411312 more ...PgrRatbisphenol A multiple interactionsISOPgr (Mus musculus)6480464bisphenol A inhibits the reaction [Progesterone results in increased expression of PGR mRNA] more ...CTDPMID:30061528 more ...PgrRatbisphenol A decreases expressionISOPGR (Homo sapiens)6480464bisphenol A results in decreased expression of PGRCTDPMID:28729173PgrRatbisphenol A affects methylationISOPgr (Mus musculus)6480464bisphenol A affects the methylation of PGR promoterCTDPMID:27334623PgrRatbisphenol A affects expressionISOPGR (Homo sapiens)6480464bisphenol A affects the expression of PGRCTDPMID:26021997PgrRatbisphenol A decreases expressionISOPgr (Mus musculus)6480464bisphenol A results in decreased expression of PGR mRNA and bisphenol A results in decreased expression of PGR proteinCTDPMID:24769007 more ...PgrRatbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of PGR mRNA and bisphenol A results in increased expression of PGR proteinCTDPMID:11474214 more ...PgrRatbisphenol A multiple interactionsEXP 6480464[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PGR mRNA more ...CTDPMID:23211298 more ...PgrRatbisphenol A increases expressionISOPgr (Mus musculus)6480464bisphenol A results in increased expression of PGR mRNA and bisphenol A results in increased expression of PGR proteinCTDPMID:15689538 more ...PgrRatbisphenol A affects bindingISOPGR (Homo sapiens)6480464bisphenol A binds to PGR proteinCTDPMID:14579009PgrRatbisphenol A increases expressionISOPGR (Homo sapiens)6480464bisphenol A analog results in increased expression of PGR mRNA more ...CTDPMID:10411312 more ...PgrRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of PGR mRNA and bisphenol A results in decreased expression of PGR proteinCTDPMID:10822019 more ...PgrRatbisphenol A affects expressionISOPgr (Mus musculus)6480464bisphenol A affects the expression of PGR mRNA and bisphenol A affects the expression of PGR proteinCTDPMID:14967926 more ...PgrRatbisphenol A dimethacrylate increases expressionISOPGR (Homo sapiens)64804642 and 2-di(4-methacryloxyphenyl)propane results in increased expression of PGR proteinCTDPMID:8919768 and PMID:9449681PgrRatBisphenol B increases expressionISOPGR (Homo sapiens)6480464bisphenol B results in increased expression of PGR mRNACTDPMID:28591870 more ...PgrRatBisphenol B multiple interactionsISOPGR (Homo sapiens)6480464bisphenol B inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:31195007PgrRatbisphenol F increases expressionISOPGR (Homo sapiens)64804644 more ...CTDPMID:28591870 more ...PgrRatbisphenol F multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [bisphenol F results in increased expression of PGR mRNA]CTDPMID:34831106PgrRatbortezomib multiple interactionsISOPGR (Homo sapiens)6480464Bortezomib binds to and results in decreased activity of PGR protein and Bortezomib inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:25752796 and PMID:30818834PgrRatbudesonide multiple interactionsISOPGR (Homo sapiens)6480464Budesonide binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatbuta-1,3-diene decreases expressionISOPgr (Mus musculus)64804641 and 3-butadiene results in decreased expression of PGR mRNACTDPMID:29038090PgrRatbutylated hydroxyanisole affects bindingISOPGR (Homo sapiens)6480464Butylated Hydroxyanisole binds to PGR proteinCTDPMID:14579009PgrRatbutylated hydroxyanisole increases expressionISOPGR (Homo sapiens)6480464Butylated Hydroxyanisole results in increased expression of PGR mRNACTDPMID:12822488PgrRatbutylated hydroxyanisole multiple interactionsISOPgr (Mus musculus)6480464Butylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]CTDPMID:21220312PgrRatbutylated hydroxyanisole multiple interactionsISOPGR (Homo sapiens)6480464Butylated Hydroxyanisole inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRatButylbenzyl phthalate increases expressionEXP 6480464butylbenzyl phthalate results in increased expression of PGR mRNACTDPMID:11474214PgrRatButylbenzyl phthalate increases expressionISOPGR (Homo sapiens)6480464butylbenzyl phthalate results in increased expression of PGR mRNACTDPMID:35307500PgrRatButylbenzyl phthalate multiple interactionsISOPGR (Homo sapiens)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA] and Cyclic AMP inhibits the reaction [[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]CTDPMID:37552060PgrRatButylbenzyl phthalate multiple interactionsISOPgr (Mus musculus)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the reaction [CGA protein results in increased expression of PGR mRNA]CTDPMID:33316053PgrRatButylparaben multiple interactionsISOPGR (Homo sapiens)6480464Silver inhibits the reaction [butylparaben results in increased expression of PGR mRNA]CTDPMID:29074358PgrRatButylparaben increases expressionISOPGR (Homo sapiens)6480464butylparaben results in increased expression of PGR mRNACTDPMID:17121429 more ...PgrRatButylparaben multiple interactionsEXP 6480464[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PGR mRNA more ...CTDPMID:19654335 and PMID:25607892PgrRatButylparaben increases expressionEXP 6480464butylparaben results in increased expression of PGR mRNA and butylparaben results in increased expression of PGR proteinCTDPMID:19654335PgrRatcadmium atom multiple interactionsISOPgr (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PGR mRNA and [Cadmium co-treated with Methimazole] results in decreased expression of PGR mRNACTDPMID:17408746 and PMID:37325564PgrRatcadmium atom increases expressionISOPGR (Homo sapiens)6480464Cadmium results in increased expression of PGR mRNA and Cadmium results in increased expression of PGR proteinCTDPMID:31646340 and PMID:8207012PgrRatcadmium atom multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [Cadmium results in increased expression of PGR mRNA] and ICI 164384 inhibits the reaction [Cadmium results in increased expression of PGR protein]CTDPMID:31646340 and PMID:8207012PgrRatcadmium dichloride increases expressionISOPGR (Homo sapiens)6480464Cadmium Chloride results in increased expression of PGRCTDPMID:22041583PgrRatcadmium dichloride multiple interactionsISOPgr (Mus musculus)6480464[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PGR mRNACTDPMID:37325564PgrRatcadmium dichloride increases expressionISOPgr (Mus musculus)6480464Cadmium Chloride results in increased expression of PGR mRNACTDPMID:21195146PgrRatcadmium dichloride increases expressionEXP 6480464Cadmium Chloride results in increased expression of PGR mRNA and Cadmium Chloride results in increased expression of PGR proteinCTDPMID:12858169 and PMID:22127542PgrRatcadmium dichloride multiple interactionsISOPGR (Homo sapiens)6480464Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of PGR]CTDPMID:22041583PgrRatcadmium dichloride multiple interactionsEXP 648046411-fluoro-7-(14 more ...CTDPMID:12858169 and PMID:22127542PgrRatcaffeine increases expressionEXP 6480464Caffeine results in increased expression of PGR mRNACTDPMID:20864626PgrRatcamphor multiple interactionsISOPGR (Homo sapiens)6480464Camphor binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatcamptothecin multiple interactionsISOPGR (Homo sapiens)6480464Camptothecin binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatcarbaryl multiple interactionsISOPGR (Homo sapiens)6480464Carbaryl inhibits the reaction [Progesterone results in increased activity of PGR protein]CTDPMID:9126867PgrRatcarbon nanotube decreases expressionISOPgr (Mus musculus)6480464Nanotubes and Carbon results in decreased expression of PGR mRNACTDPMID:25554681PgrRatcarfilzomib multiple interactionsISOPGR (Homo sapiens)6480464carfilzomib inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRatchlordecone affects bindingISOPGR (Homo sapiens)6480464Chlordecone binds to PGR proteinCTDPMID:14579009PgrRatchlordecone increases expressionISOPGR (Homo sapiens)6480464Chlordecone results in increased expression of PGR mRNACTDPMID:35307500PgrRatchlordecone increases expressionEXP 6480464Chlordecone results in increased expression of PGR mRNACTDPMID:10774817PgrRatchlordecone multiple interactionsISOPgr (Mus musculus)6480464fulvestrant affects the reaction [Chlordecone results in increased expression of PGR mRNA]CTDPMID:9607801PgrRatchlordecone increases expressionISOPgr (Mus musculus)6480464Chlordecone results in increased expression of PGR mRNACTDPMID:9607801PgrRatchlordecone multiple interactionsISOPGR (Homo sapiens)6480464Chlordecone inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRatchlorogenic acid decreases expressionISOPGR (Homo sapiens)6480464Chlorogenic Acid results in decreased expression of PGR mRNACTDPMID:20706672PgrRatchlorogenic acid increases expressionISOPGR (Homo sapiens)6480464Chlorogenic Acid results in increased expression of PGR mRNACTDPMID:20706672PgrRatchlorpyrifos affects bindingISOPGR (Homo sapiens)6480464Chlorpyrifos binds to PGR protein and Chlorpyrifos metabolite binds to PGR proteinCTDPMID:31889325PgrRatchlorpyrifos decreases expressionISOPGR (Homo sapiens)6480464Chlorpyrifos results in decreased expression of PGR mRNACTDPMID:35457321PgrRatchlorpyrifos increases expressionEXP 6480464Chlorpyrifos results in increased expression of PGR proteinCTDPMID:26518068PgrRatchlorpyrifos multiple interactionsISOPGR (Homo sapiens)6480464Chlorpyrifos inhibits the reaction [Progesterone binds to PGR protein] and Chlorpyrifos metabolite inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:31889325PgrRatChorionic gonadotropin multiple interactionsISOPGR (Homo sapiens)6480464Atrazine inhibits the reaction [Chorionic Gonadotropin results in increased expression of PGR mRNA]CTDPMID:26923738PgrRatChorionic gonadotropin increases expressionISOPGR (Homo sapiens)6480464Chorionic Gonadotropin results in increased expression of PGR mRNACTDPMID:26923738PgrRatchrysen-6-ol multiple interactionsISOPGR (Homo sapiens)64804646-hydroxychrysene inhibits the reaction [Progesterone binds to PGR protein] and [Progesterone co-treated with 6-hydroxychrysene] results in decreased expression of PGR mRNACTDPMID:9144411PgrRatCiclesonide multiple interactionsISOPGR (Homo sapiens)6480464ciclesonide binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatciclopirox multiple interactionsISOPGR (Homo sapiens)6480464ciclopirox binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatclomiphene increases expressionISOPGR (Homo sapiens)6480464Clomiphene results in increased expression of PGR proteinCTDPMID:15749485PgrRatclomiphene multiple interactionsISOPGR (Homo sapiens)6480464Clomiphene binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatcobalt dichloride multiple interactionsISOPGR (Homo sapiens)6480464cobaltous chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA] more ...CTDPMID:12746304PgrRatcobalt dichloride increases expressionISOPGR (Homo sapiens)6480464cobaltous chloride results in increased expression of PGR mRNA and cobaltous chloride results in increased expression of PGR proteinCTDPMID:12746304PgrRatcocaine increases expressionEXP 6480464Cocaine results in increased expression of PGR proteinCTDPMID:17109827PgrRatcocaine affects expressionEXP 6480464Cocaine affects the expression of PGR mRNACTDPMID:20187946PgrRatcolforsin daropate hydrochloride increases expressionISOPgr (Mus musculus)6480464Colforsin results in increased expression of PGR mRNACTDPMID:20378682PgrRatcopper(II) chloride multiple interactionsISOPGR (Homo sapiens)6480464cupric chloride promotes the reaction [Estradiol results in increased expression of PGR mRNA] more ...CTDPMID:12746304PgrRatcopper(II) chloride increases expressionISOPGR (Homo sapiens)6480464cupric chloride results in increased expression of PGR mRNA and cupric chloride results in increased expression of PGR proteinCTDPMID:12746304PgrRatcoumestrol increases expressionEXP 6480464Coumestrol results in increased expression of PGR mRNACTDPMID:10397250PgrRatcoumestrol multiple interactionsEXP 6480464[Fulvestrant co-treated with Coumestrol] results in decreased expression of PGR mRNACTDPMID:34848279PgrRatcoumestrol multiple interactionsISOPgr (Mus musculus)6480464Coumestrol inhibits the reaction [Estradiol results in increased expression of PGR protein]CTDPMID:11368421PgrRatcoumestrol increases expressionISOPGR (Homo sapiens)6480464Coumestrol results in increased expression of PGR mRNACTDPMID:11867264 more ...PgrRatcoumestrol multiple interactionsISOPGR (Homo sapiens)6480464ESR1 protein inhibits the reaction [Coumestrol results in increased expression of PGR mRNA]CTDPMID:23384675PgrRatCuprizon decreases expressionEXP 6480464Cuprizone results in decreased expression of PGR mRNACTDPMID:26577399 and PMID:27523638PgrRatcyclohexanone multiple interactionsISOPGR (Homo sapiens)6480464cyclohexanone binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatcyfluthrin affects bindingISOPGR (Homo sapiens)6480464cyfluthrin binds to PGR proteinCTDPMID:32278787PgrRatcyhalothrin increases expressionISOPGR (Homo sapiens)6480464cyhalothrin results in increased expression of PGR mRNACTDPMID:18419197PgrRatcyhalothrin affects bindingISOPGR (Homo sapiens)6480464cyhalothrin binds to PGR proteinCTDPMID:32278787PgrRatcypermethrin increases expressionISOPgr (Mus musculus)6480464cypermethrin results in increased expression of PGR mRNA and cypermethrin results in increased expression of PGR proteinCTDPMID:29253587PgrRatcypermethrin decreases expressionISOPgr (Mus musculus)6480464cypermethrin results in decreased expression of PGR proteinCTDPMID:36116546PgrRatcypermethrin affects bindingISOPGR (Homo sapiens)6480464cypermethrin binds to PGR proteinCTDPMID:32278787PgrRatcyproterone acetate multiple interactionsISOPGR (Homo sapiens)6480464[Cyproterone Acetate binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to PGR protein modified form] and Cyproterone Acetate binds to and results in increased activity of PGR proteinCTDPMID:20599585 and PMID:28751236PgrRatdaidzein increases expressionISOPGR (Homo sapiens)6480464daidzein results in increased expression of PGR mRNA and daidzein results in increased expression of PGR proteinCTDPMID:17142977 and PMID:23384675PgrRatdaidzein multiple interactionsISOPGR (Homo sapiens)6480464ESR1 protein inhibits the reaction [daidzein results in increased expression of PGR mRNA]CTDPMID:23384675PgrRatdaidzein 7-O-beta-D-glucoside increases expressionISOPGR (Homo sapiens)6480464daidzin results in increased expression of PGR proteinCTDPMID:17142977PgrRatdanazol multiple interactionsISOPGR (Homo sapiens)6480464Danazol binds to and results in decreased activity of PGR protein and Danazol binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatDDD multiple interactionsISOPGR (Homo sapiens)6480464Dichlorodiphenyldichloroethane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatDDE affects bindingISOPGR (Homo sapiens)6480464Dichlorodiphenyl Dichloroethylene binds to PGR proteinCTDPMID:14579009 and PMID:32278787PgrRatDDE multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatDDE increases expressionISOPGR (Homo sapiens)6480464Dichlorodiphenyl Dichloroethylene results in increased expression of PGR mRNA and Dichlorodiphenyl Dichloroethylene results in increased expression of PGR proteinCTDPMID:16859517 and PMID:20206645PgrRatDDE multiple interactionsISOPGR (Homo sapiens)6480464Dichlorodiphenyl Dichloroethylene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 more ...CTDPMID:14579009 more ...PgrRatDDT affects bindingISOPGR (Homo sapiens)6480464DDT binds to PGR proteinCTDPMID:14579009PgrRatDDT decreases expressionISOPGR (Homo sapiens)6480464DDT results in decreased expression of PGR mRNACTDPMID:33728745PgrRatDDT increases expressionISOPgr (Mus musculus)6480464DDT results in increased expression of PGR mRNACTDPMID:15541753 and PMID:9607801PgrRatDDT multiple interactionsISOPGR (Homo sapiens)6480464[DDT results in increased activity of ESR1 protein] which results in increased expression of PGR mRNA more ...CTDPMID:14579009 more ...PgrRatdelta-hexachlorocyclohexane multiple interactionsISOPGR (Homo sapiens)6480464delta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatdeoxynivalenol multiple interactionsISOPGR (Homo sapiens)6480464afimoxifene inhibits the reaction [deoxynivalenol results in increased expression of PGR mRNA] more ...CTDPMID:35588983PgrRatdeoxynivalenol increases expressionISOPGR (Homo sapiens)6480464deoxynivalenol results in increased expression of PGR mRNACTDPMID:35588983PgrRatdesogestrel multiple interactionsISOPGR (Homo sapiens)6480464Desogestrel binds to and affects the activity of PGR proteinCTDPMID:15697108PgrRatdiarylheptanoid increases expressionISOPGR (Homo sapiens)6480464Diarylheptanoids results in increased expression of PGR mRNACTDPMID:19654927PgrRatdiarylheptanoid affects expressionISOPgr (Mus musculus)6480464Diarylheptanoids affects the expression of PGR proteinCTDPMID:23552522PgrRatdiarylheptanoid multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [Diarylheptanoids results in increased expression of PGR mRNA]CTDPMID:19654927PgrRatdibutyl phthalate multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNA more ...CTDPMID:23294617 and PMID:25607892PgrRatdibutyl phthalate multiple interactionsISOPGR (Homo sapiens)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA] and Cyclic AMP inhibits the reaction [[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]CTDPMID:37552060PgrRatdibutyl phthalate multiple interactionsISOPgr (Mus musculus)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the reaction [CGA protein results in increased expression of PGR mRNA]CTDPMID:33316053PgrRatdibutyl phthalate increases expressionEXP 6480464Dibutyl Phthalate results in increased expression of PGR mRNACTDPMID:23294617PgrRatdichloroacetic acid increases expressionISOPgr (Mus musculus)6480464Dichloroacetic Acid results in increased expression of PGR mRNACTDPMID:28962523PgrRatdieldrin increases expressionEXP 6480464Dieldrin results in increased expression of PGR mRNACTDPMID:10774817PgrRatdieldrin multiple interactionsISOPGR (Homo sapiens)6480464Dieldrin inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatdiethyl phthalate increases expressionEXP 6480464diethyl phthalate results in increased expression of PGR proteinCTDPMID:24994688PgrRatdiethyl phthalate multiple interactionsISOPGR (Homo sapiens)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA] and Cyclic AMP inhibits the reaction [[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]CTDPMID:37552060PgrRatdiethyl phthalate multiple interactionsISOPgr (Mus musculus)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the reaction [CGA protein results in increased expression of PGR mRNA]CTDPMID:33316053PgrRatdiethylstilbestrol increases expressionEXP 6480464Diethylstilbestrol results in increased expression of PGR mRNA and Diethylstilbestrol results in increased expression of PGR proteinCTDPMID:10397250 more ...PgrRatdiethylstilbestrol increases expressionISOPGR (Homo sapiens)6480464Diethylstilbestrol results in increased expression of PGR mRNA and Diethylstilbestrol results in increased expression of PGR proteinCTDPMID:11391616 more ...PgrRatdiethylstilbestrol decreases expressionEXP 6480464Diethylstilbestrol results in decreased expression of PGR mRNA and Diethylstilbestrol results in decreased expression of PGR proteinCTDPMID:21285323PgrRatdiethylstilbestrol multiple interactionsEXP 6480464Diethylstilbestrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of PGR protein]CTDPMID:18653720PgrRatdiethylstilbestrol multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [Diethylstilbestrol results in increased expression of PGR mRNA]CTDPMID:11391616PgrRatdifenoconazole affects bindingISOPGR (Homo sapiens)6480464difenoconazole binds to PGR proteinCTDPMID:32278787PgrRatdigitoxin multiple interactionsISOPGR (Homo sapiens)6480464Digitoxin binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatdiisobutyl phthalate multiple interactionsISOPgr (Mus musculus)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the reaction [CGA protein results in increased expression of PGR mRNA]CTDPMID:33316053PgrRatdiisobutyl phthalate multiple interactionsISOPGR (Homo sapiens)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA] and Cyclic AMP inhibits the reaction [[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]CTDPMID:37552060PgrRatdiisononyl phthalate decreases expressionEXP 6480464diisononyl phthalate results in decreased expression of PGR mRNACTDPMID:16183386PgrRatdiisononyl phthalate multiple interactionsISOPGR (Homo sapiens)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA] and Cyclic AMP inhibits the reaction [[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]CTDPMID:37552060PgrRatdiisononyl phthalate multiple interactionsISOPgr (Mus musculus)6480464[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] affects the reaction [CGA protein results in increased expression of PGR mRNA]CTDPMID:33316053PgrRatdioxygen affects expressionEXP 6480464Oxygen deficiency affects the expression of PGR mRNACTDPMID:18457817PgrRatdioxygen multiple interactionsISOPgr (Mus musculus)6480464[NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of PGR mRNACTDPMID:30529165PgrRatdisodium selenite affects expressionISOPGR (Homo sapiens)6480464Sodium Selenite affects the expression of PGR mRNACTDPMID:16928829PgrRatdoxorubicin increases expressionISOPGR (Homo sapiens)6480464Doxorubicin results in increased expression of PGR mRNACTDPMID:19351845PgrRatdoxorubicin decreases expressionISOPGR (Homo sapiens)6480464Doxorubicin results in decreased expression of PGR mRNACTDPMID:29803840 and PMID:30031762PgrRatdoxorubicin multiple interactionsISOPGR (Homo sapiens)6480464Doxorubicin binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatdronedarone multiple interactionsISOPGR (Homo sapiens)6480464dronedarone binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatdrospirenone affects bindingISOPGR (Homo sapiens)6480464drospirenone binds to PGR proteinCTDPMID:14667981PgrRatdydrogesterone affects activityISOPGR (Homo sapiens)6480464Dydrogesterone affects the activity of PGR proteinCTDPMID:16045524PgrRatdydrogesterone decreases expressionISOPGR (Homo sapiens)6480464Dydrogesterone results in decreased expression of PGR mRNACTDPMID:23183084PgrRatelcometrine multiple interactionsISOPGR (Homo sapiens)6480464ST 1435 binds to and results in increased activity of PGR proteinCTDPMID:20599585PgrRatemetine multiple interactionsISOPGR (Homo sapiens)6480464Emetine binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatendosulfan affects bindingISOPGR (Homo sapiens)6480464Endosulfan binds to PGR proteinCTDPMID:14579009PgrRatendosulfan multiple interactionsEXP 6480464[Endosulfan co-treated with Glyphosate] results in increased expression of PGR proteinCTDPMID:31550491PgrRatendosulfan decreases expressionISOPGR (Homo sapiens)6480464Endosulfan results in decreased expression of PGR mRNACTDPMID:33728745PgrRatendosulfan decreases expressionEXP 6480464Endosulfan results in decreased expression of PGR mRNA and Endosulfan results in decreased expression of PGR proteinCTDPMID:18790044 and PMID:22198180PgrRatendosulfan increases expressionEXP 6480464Endosulfan results in increased expression of PGR mRNA and Endosulfan results in increased expression of PGR proteinCTDPMID:10397250 more ...PgrRatendosulfan increases expressionISOPGR (Homo sapiens)6480464Endosulfan results in increased expression of PGR mRNACTDPMID:16242299PgrRatendosulfan multiple interactionsISOPGR (Homo sapiens)6480464[Progesterone co-treated with Endosulfan] results in decreased expression of PGR mRNA more ...CTDPMID:14579009 more ...PgrRatendrin multiple interactionsISOPGR (Homo sapiens)6480464Endrin inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatenzacamene affects expressionEXP 6480464enzacamene affects the expression of PGR mRNACTDPMID:19150460PgrRatenzacamene multiple interactionsEXP 6480464[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatenzacamene multiple interactionsISOPGR (Homo sapiens)6480464enzacamene binds to and results in decreased activity of PGR proteinCTDPMID:15537743PgrRatepoxiconazole multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNACTDPMID:25607892PgrRaterucamide multiple interactionsISOPGR (Homo sapiens)6480464erucyl amide binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatEstradiol dipropionate multiple interactionsISOPgr (Mus musculus)6480464[estradiol dipropionate co-treated with Butyrates] results in decreased expression of PGR protein and [estradiol dipropionate co-treated with trichostatin A] results in decreased expression of PGR proteinCTDPMID:15930180PgrRatestriol increases expressionISOPGR (Homo sapiens)6480464Estriol results in increased expression of PGR mRNACTDPMID:19820872PgrRatestrogen increases expression EXP 152177689estrogen increases expression of Pgr mRNA in rat uterusRGD PgrRatestrone decreases expressionISOPGR (Homo sapiens)6480464Estrone results in decreased expression of PGR mRNA alternative form and Estrone results in decreased expression of PGR protein alternative formCTDPMID:15806153PgrRatestrone increases expressionISOPGR (Homo sapiens)6480464Estrone results in increased expression of PGR mRNACTDPMID:26865669PgrRatestrone multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [Estrone results in decreased expression of PGR protein alternative form]CTDPMID:15806153PgrRatethanol multiple interactionsEXP 6480464[Ethanol co-treated with Melatonin] results in decreased expression of PGR protein alternative form more ...CTDPMID:23591044PgrRatethanol increases expressionEXP 6480464Ethanol results in increased expression of PGR protein alternative formCTDPMID:23591044PgrRatethanol decreases expressionEXP 6480464Ethanol results in decreased expression of PGR protein alternative formCTDPMID:23591044PgrRatethyl myristate multiple interactionsISOPGR (Homo sapiens)6480464ethyl myristate binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatethylparaben decreases expressionISOPgr (Mus musculus)6480464ethyl-p-hydroxybenzoate results in decreased expression of PGR mRNACTDPMID:34101200PgrRatethylparaben increases expressionISOPGR (Homo sapiens)6480464ethyl-p-hydroxybenzoate results in increased expression of PGR mRNACTDPMID:35307500PgrRatetonogestrel increases expressionISOPGR (Homo sapiens)6480464etonogestrel results in increased expression of PGR proteinCTDPMID:11041225PgrRatetoposide phosphate multiple interactionsISOPGR (Homo sapiens)6480464etoposide phosphate binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatexemestane decreases expressionISOPGR (Homo sapiens)6480464exemestane results in decreased expression of PGR proteinCTDPMID:15909811 and PMID:16002280PgrRatexemestane increases expressionISOPGR (Homo sapiens)6480464exemestane results in increased expression of PGR mRNACTDPMID:18677558PgrRatezetimibe multiple interactionsISOPGR (Homo sapiens)6480464Ezetimibe binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatfenhexamid decreases expressionISOPGR (Homo sapiens)6480464N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in decreased expression of PGR mRNACTDPMID:23052036PgrRatfenhexamid affects bindingISOPGR (Homo sapiens)6480464N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to PGR proteinCTDPMID:32278787PgrRatfenhexamid increases expressionISOPGR (Homo sapiens)6480464N-(2 and 3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PGR mRNACTDPMID:23436777PgrRatfenpyroximate multiple interactionsISOPGR (Homo sapiens)6480464fenpyroximate inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRatfenvalerate multiple interactionsISOPGR (Homo sapiens)6480464fenvalerate inhibits the reaction [Progesterone results in increased expression of PGR protein]CTDPMID:16326432PgrRatfludioxonil increases expressionISOPGR (Homo sapiens)6480464fludioxonil results in increased expression of PGR mRNACTDPMID:23436777PgrRatfludioxonil multiple interactionsISOPGR (Homo sapiens)6480464Estradiol inhibits the reaction [fludioxonil results in increased expression of PGR mRNA]CTDPMID:23436777PgrRatfludioxonil decreases expressionISOPGR (Homo sapiens)6480464fludioxonil results in decreased expression of PGR mRNACTDPMID:23052036PgrRatflumethrin increases expressionISOPGR (Homo sapiens)6480464flumethrin results in increased expression of PGR mRNACTDPMID:34142587PgrRatflunisolide multiple interactionsISOPGR (Homo sapiens)6480464flunisolide binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatfluoxastrobin multiple interactionsISOPGR (Homo sapiens)6480464fluoxastrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRatflutamide increases expressionEXP 6480464Flutamide results in increased expression of PGR proteinCTDPMID:11748029PgrRatflutamide decreases expressionEXP 6480464Flutamide results in decreased expression of PGR mRNACTDPMID:32738380PgrRatflutamide multiple interactionsISOPGR (Homo sapiens)6480464Flutamide binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatfluticasone multiple interactionsISOPGR (Homo sapiens)6480464Fluticasone binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatflutolanil increases expressionISOPGR (Homo sapiens)6480464flutolanil results in increased expression of PGR mRNACTDPMID:17904202PgrRatfulvestrant multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant binds to and results in decreased activity of PGR protein more ...CTDPMID:10411312 more ...PgrRatfulvestrant decreases expressionISOPgr (Mus musculus)6480464Fulvestrant results in decreased expression of PGR mRNACTDPMID:30061528PgrRatfulvestrant multiple interactionsEXP 6480464[Fulvestrant co-treated with Coumestrol] results in decreased expression of PGR mRNA more ...CTDPMID:12858169 more ...PgrRatfulvestrant multiple interactionsISOPgr (Mus musculus)6480464bisphenol A promotes the reaction [Fulvestrant results in decreased expression of PGR mRNA] more ...CTDPMID:30061528 more ...PgrRatfulvestrant decreases expressionISOPGR (Homo sapiens)6480464Fulvestrant results in decreased expression of PGR mRNA and Fulvestrant results in decreased expression of PGR proteinCTDPMID:11867264 more ...PgrRatgalaxolide multiple interactionsISOPGR (Homo sapiens)6480464galaxolide binds to and results in decreased activity of PGR proteinCTDPMID:15537743PgrRatgamma-hexachlorocyclohexane affects bindingISOPGR (Homo sapiens)6480464Hexachlorocyclohexane binds to PGR proteinCTDPMID:14579009PgrRatgamma-hexachlorocyclohexane multiple interactionsISOPGR (Homo sapiens)6480464[Progesterone co-treated with Hexachlorocyclohexane] results in decreased expression of PGR mRNA more ...CTDPMID:14579009 more ...PgrRatgamma-terpinene increases expressionISOPGR (Homo sapiens)6480464gamma-terpinene results in increased expression of PGR mRNACTDPMID:31393563PgrRatgamma-terpinene multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [gamma-terpinene results in increased expression of PGR mRNA]CTDPMID:31393563PgrRatgeldanamycin decreases expressionISOPGR (Homo sapiens)6480464geldanamycin results in decreased expression of PGR proteinCTDPMID:11448926PgrRatgemcitabine multiple interactionsISOPGR (Homo sapiens)6480464Gemcitabine binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatgenistein increases expressionISOPGR (Homo sapiens)6480464Genistein results in increased expression of PGR mRNA and Genistein results in increased expression of PGR proteinCTDPMID:10376965 more ...PgrRatgenistein affects expressionEXP 6480464Genistein affects the expression of PGR mRNACTDPMID:23410115PgrRatgenistein decreases expressionISOPGR (Homo sapiens)6480464Genistein results in decreased expression of PGR mRNACTDPMID:20706672PgrRatgenistein decreases expressionISOPgr (Mus musculus)6480464Genistein results in decreased expression of PGR mRNACTDPMID:11880592 more ...PgrRatgenistein increases expressionEXP 6480464Genistein results in increased expression of PGR mRNA more ...CTDPMID:10397250 more ...PgrRatgenistein decreases expressionEXP 6480464Genistein results in decreased expression of PGRCTDPMID:12929590PgrRatgenistein multiple interactionsEXP 6480464[Genistein co-treated with vinclozolin] affects the expression of PGR mRNA more ...CTDPMID:11896288 more ...PgrRatgenistein increases expressionISOPgr (Mus musculus)6480464Genistein results in increased expression of PGR mRNA and Genistein results in increased expression of PGR proteinCTDPMID:16857750 more ...PgrRatgenistein multiple interactionsISOPGR (Homo sapiens)6480464ESR1 protein inhibits the reaction [Genistein results in increased expression of PGR mRNA] and Genistein promotes the reaction [Estradiol results in increased expression of PGR protein]CTDPMID:10376965 and PMID:23384675PgrRatgentamycin decreases expressionEXP 6480464Gentamicins results in decreased expression of PGR mRNACTDPMID:22061828PgrRatgeraniol multiple interactionsEXP 6480464geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PGR protein]CTDPMID:28428697PgrRatgestodene multiple interactionsISOPGR (Homo sapiens)6480464Gestodene binds to and affects the activity of PGR protein and Gestodene binds to and results in increased activity of PGR proteinCTDPMID:15697108 and PMID:25752796PgrRatginsenoside Rb1 increases expressionISOPGR (Homo sapiens)6480464ginsenoside Rb1 results in increased expression of PGR proteinCTDPMID:16204943PgrRatginsenoside Re multiple interactionsISOPGR (Homo sapiens)6480464ginsenoside Re binds to and affects the activity of PGR proteinCTDPMID:16985185PgrRatginsenoside Re increases expressionISOPGR (Homo sapiens)6480464ginsenoside Re results in increased expression of PGR proteinCTDPMID:16204943PgrRatginsenoside Rg1 increases expressionISOPGR (Homo sapiens)6480464ginsenoside Rg1 results in increased expression of PGR proteinCTDPMID:16204943PgrRatglutathione multiple interactionsISOPgr (Mus musculus)6480464Glutathione inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]CTDPMID:21220312PgrRatglyceollin multiple interactionsISOPGR (Homo sapiens)6480464[Tamoxifen co-treated with glyceollin] results in decreased expression of PGR mRNA more ...CTDPMID:19797619PgrRatglyphosate increases expressionISOPGR (Homo sapiens)6480464Glyphosate results in increased expression of PGR mRNACTDPMID:28711546PgrRatglyphosate affects expressionISOPGR (Homo sapiens)6480464Glyphosate affects the expression of PGR mRNACTDPMID:35457321PgrRatglyphosate decreases expressionEXP 6480464Glyphosate results in decreased expression of PGR mRNA and Glyphosate results in decreased expression of PGR proteinCTDPMID:27463640 more ...PgrRatglyphosate multiple interactionsEXP 6480464[Endosulfan co-treated with Glyphosate] results in increased expression of PGR proteinCTDPMID:31550491PgrRatglyphosate increases expressionEXP 6480464Glyphosate results in increased expression of PGR proteinCTDPMID:27287056 more ...PgrRatglyphosate increases expressionISOPgr (Mus musculus)6480464Glyphosate results in increased expression of PGR mRNACTDPMID:37657410PgrRatGoserelin decreases expressionISOPGR (Homo sapiens)6480464Goserelin results in decreased expression of PGR proteinCTDPMID:16973256PgrRatheptachlor increases expressionEXP 6480464Heptachlor results in increased expression of PGRCTDPMID:27240701PgrRatheptachlor multiple interactionsISOPGR (Homo sapiens)6480464Heptachlor inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatHeptachlor epoxide multiple interactionsISOPGR (Homo sapiens)6480464ICI 164384 inhibits the reaction [Heptachlor Epoxide results in increased expression of PGR mRNA]CTDPMID:16242299PgrRatHeptachlor epoxide increases expressionISOPGR (Homo sapiens)6480464Heptachlor Epoxide results in increased expression of PGR mRNACTDPMID:16242299PgrRatherbicide decreases expressionISOPGR (Homo sapiens)6480464Herbicides results in decreased expression of PGR mRNACTDPMID:28711546PgrRathexachlorobenzene decreases expressionISOPGR (Homo sapiens)6480464Hexachlorobenzene results in decreased expression of PGR proteinCTDPMID:35181438PgrRathexestrol increases expressionISOPGR (Homo sapiens)6480464Hexestrol results in increased expression of PGR mRNACTDPMID:26865669 and PMID:35307500PgrRathydrogen peroxide increases expressionISOPgr (Mus musculus)6480464Hydrogen Peroxide results in increased expression of PGR mRNACTDPMID:21220312PgrRathydrogen peroxide multiple interactionsISOPgr (Mus musculus)6480464N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of PGR mRNA] and U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of PGR mRNA]CTDPMID:21220312PgrRaticariin increases expressionISOPGR (Homo sapiens)6480464icariin results in increased expression of PGR mRNACTDPMID:15541416PgrRaticariin multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [icariin results in increased expression of PGR mRNA]CTDPMID:15541416PgrRatIcaritin increases expressionISOPGR (Homo sapiens)6480464icaritin results in increased expression of PGR mRNACTDPMID:16323292PgrRatIcaritin multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [icaritin results in increased expression of PGR mRNA]CTDPMID:16323292PgrRatICI-164384 multiple interactionsISOPGR (Homo sapiens)6480464ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA] more ...CTDPMID:16242299 and PMID:8207012PgrRatimidacloprid affects expressionISOPGR (Homo sapiens)6480464imidacloprid affects the expression of PGR mRNACTDPMID:35457321PgrRatIndeno[1,2,3-cd]pyrene decreases expressionISOPGR (Homo sapiens)6480464indeno(1 more ...CTDPMID:32251684PgrRatirilone increases expressionISOPGR (Homo sapiens)6480464irilone results in increased expression of PGR mRNACTDPMID:23982890PgrRatIsobavachin multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR mRNA] and Fulvestrant inhibits the reaction [isobavachin results in increased expression of PGR protein]CTDPMID:16892383PgrRatIsobavachin increases expressionISOPGR (Homo sapiens)6480464isobavachin results in increased expression of PGR mRNA and isobavachin results in increased expression of PGR proteinCTDPMID:16892383PgrRatIsobutylparaben increases expressionEXP 6480464isobutylparaben results in increased expression of PGR proteinCTDPMID:23211298PgrRatIsobutylparaben multiple interactionsEXP 6480464[isobutylparaben co-treated with bisphenol A] results in increased expression of PGR mRNA more ...CTDPMID:23211298PgrRatisoflavones multiple interactionsEXP 6480464Isoflavones inhibits the reaction [Estradiol results in increased expression of PGR mRNA] and Isoflavones promotes the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:23288143PgrRatisoflavones increases expressionEXP 6480464Isoflavones results in increased expression of PGR mRNACTDPMID:23288143PgrRatisoflavones decreases expressionEXP 6480464Isoflavones results in decreased expression of PGR mRNACTDPMID:23288143PgrRatisophorone multiple interactionsISOPGR (Homo sapiens)6480464isophorone binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatIsopropylparaben multiple interactionsEXP 6480464Fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of PGR mRNA] and Fulvestrant inhibits the reaction [isopropyl 4-hydroxybenzoate results in increased expression of PGR protein]CTDPMID:19654335PgrRatIsopropylparaben increases expressionEXP 6480464isopropyl 4-hydroxybenzoate results in increased expression of PGR mRNA and isopropyl 4-hydroxybenzoate results in increased expression of PGR proteinCTDPMID:19654335PgrRatisoprothiolane increases expressionISOPGR (Homo sapiens)6480464isoprothiolane results in increased expression of PGR mRNACTDPMID:17904202PgrRatkaempferol affects bindingISOPGR (Homo sapiens)6480464kaempferol binds to PGR proteinCTDPMID:14579009PgrRatkaempferol increases expressionISOPGR (Homo sapiens)6480464kaempferol results in increased expression of PGR mRNACTDPMID:23384675 and PMID:35307500PgrRatkaempferol multiple interactionsISOPGR (Homo sapiens)6480464ESR1 protein inhibits the reaction [kaempferol results in increased expression of PGR mRNA] and kaempferol inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009 and PMID:23384675PgrRatketoconazole increases expressionISOPGR (Homo sapiens)6480464Ketoconazole results in increased expression of PGR mRNACTDPMID:35307500PgrRatkresoxim-methyl multiple interactionsISOPGR (Homo sapiens)6480464kresoxim-methyl inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRatlasofoxifene increases expressionEXP 6480464Lasofoxifene results in increased expression of PGR proteinCTDPMID:16837883PgrRatLaurolactam multiple interactionsISOPGR (Homo sapiens)6480464laurolactam binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatlead(II) chloride multiple interactionsISOPGR (Homo sapiens)6480464Estradiol promotes the reaction [lead chloride results in increased expression of PGR mRNA] more ...CTDPMID:12746304PgrRatlead(II) chloride increases expressionISOPGR (Homo sapiens)6480464lead chloride results in increased expression of PGR mRNA and lead chloride results in increased expression of PGR proteinCTDPMID:12746304PgrRatletrozole decreases expressionISOPGR (Homo sapiens)6480464letrozole results in decreased expression of PGR proteinCTDPMID:16002280PgrRatlevonorgestrel multiple interactionsISOPGR (Homo sapiens)6480464Levonorgestrel binds to and results in increased activity of PGR proteinCTDPMID:20599585PgrRatlimonene multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [Limonene results in increased expression of PGR mRNA]CTDPMID:31393563PgrRatlimonene increases expressionISOPGR (Homo sapiens)6480464Limonene results in increased expression of PGR mRNACTDPMID:31393563PgrRatlinalool increases expressionISOPGR (Homo sapiens)6480464linalool results in increased expression of PGR mRNACTDPMID:31393563PgrRatlinalool multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [linalool results in increased expression of PGR mRNA]CTDPMID:31393563PgrRatlinalyl acetate increases expressionISOPGR (Homo sapiens)6480464linalyl acetate results in increased expression of PGR mRNACTDPMID:31393563PgrRatlinalyl acetate multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [linalyl acetate results in increased expression of PGR mRNA]CTDPMID:31393563PgrRatlinuron multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatloteprednol etabonate multiple interactionsISOPGR (Homo sapiens)6480464Loteprednol Etabonate binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatmedroxyprogesterone multiple interactionsISOPGR (Homo sapiens)6480464Medroxyprogesterone binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatmedroxyprogesterone acetate decreases expressionISOPgr (Mus musculus)6480464Medroxyprogesterone Acetate results in decreased expression of PGR proteinCTDPMID:2151368PgrRatmedroxyprogesterone acetate decreases expressionISOPGR (Homo sapiens)6480464Medroxyprogesterone Acetate results in decreased expression of PGR mRNA and Medroxyprogesterone Acetate results in decreased expression of PGR proteinCTDPMID:20843944 and PMID:23183084PgrRatmedroxyprogesterone acetate multiple interactionsISOPGR (Homo sapiens)6480464Medroxyprogesterone Acetate promotes the reaction [PGR protein binds to NCOA1 protein]CTDPMID:15937332PgrRatmegestrol acetate multiple interactionsISOPGR (Homo sapiens)6480464Megestrol Acetate binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatmelatonin multiple interactionsISOPGR (Homo sapiens)6480464Melatonin inhibits the reaction [Cadmium Chloride results in increased expression of PGR]CTDPMID:22041583PgrRatmelatonin decreases expressionEXP 6480464Melatonin results in decreased expression of PGR protein alternative formCTDPMID:23591044PgrRatmelatonin multiple interactionsEXP 6480464[Ethanol co-treated with Melatonin] results in decreased expression of PGR protein alternative form more ...CTDPMID:23591044PgrRatmercaptopurine increases expressionEXP 6480464Mercaptopurine results in increased expression of PGR mRNACTDPMID:23358152PgrRatmercury dichloride multiple interactionsISOPGR (Homo sapiens)6480464Estradiol promotes the reaction [Mercuric Chloride results in increased expression of PGR mRNA] more ...CTDPMID:12746304PgrRatmercury dichloride increases expressionISOPGR (Homo sapiens)6480464Mercuric Chloride results in increased expression of PGR mRNA and Mercuric Chloride results in increased expression of PGR proteinCTDPMID:12746304PgrRatmestranol increases expressionISOPGR (Homo sapiens)6480464Mestranol results in increased expression of PGR mRNACTDPMID:26865669PgrRatmethimazole multiple interactionsISOPgr (Mus musculus)6480464[Cadmium co-treated with Methimazole] results in decreased expression of PGR mRNACTDPMID:17408746PgrRatmethomyl multiple interactionsISOPGR (Homo sapiens)6480464Methomyl inhibits the reaction [Progesterone results in increased activity of PGR protein]CTDPMID:9126867PgrRatmethotrexate multiple interactionsISOPGR (Homo sapiens)6480464Methotrexate binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatmethoxyacetic acid multiple interactionsISOPGR (Homo sapiens)6480464methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein] more ...CTDPMID:15103026 and PMID:18486176PgrRatmethoxyacetic acid increases expressionEXP 6480464methoxyacetic acid results in increased expression of PGR mRNACTDPMID:20864626PgrRatmethoxychlor affects bindingISOPGR (Homo sapiens)6480464Methoxychlor binds to PGR proteinCTDPMID:14579009PgrRatmethoxychlor affects methylationEXP 6480464Methoxychlor affects the methylation of PGR geneCTDPMID:35440735PgrRatmethoxychlor increases expressionISOPGR (Homo sapiens)6480464Methoxychlor results in increased expression of PGR mRNACTDPMID:35307500PgrRatmethoxychlor decreases expressionEXP 6480464Methoxychlor results in decreased expression of PGR mRNACTDPMID:16183386 and PMID:23303685PgrRatmethoxychlor increases expressionEXP 6480464Methoxychlor results in increased expression of PGR mRNACTDPMID:10774817 and PMID:16183386PgrRatmethoxychlor increases expressionISOPgr (Mus musculus)6480464Methoxychlor results in increased expression of PGR mRNACTDPMID:21252393PgrRatmethoxychlor multiple interactionsEXP 6480464[Methoxychlor co-treated with Genistein] results in increased expression of PGR proteinCTDPMID:11896288PgrRatmethoxychlor decreases expressionISOPgr (Mus musculus)6480464Methoxychlor metabolite results in decreased expression of PGR mRNACTDPMID:11509743PgrRatmethoxychlor multiple interactionsISOPgr (Mus musculus)6480464[Estradiol co-treated with Methoxychlor metabolite] results in decreased expression of PGR mRNA more ...CTDPMID:11509743 and PMID:21252393PgrRatmethoxychlor multiple interactionsISOPGR (Homo sapiens)6480464Methoxychlor inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRatmethyl laurate multiple interactionsISOPGR (Homo sapiens)6480464lauric acid methyl ester binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatmethylmercury chloride increases expressionEXP 6480464methylmercuric chloride results in increased expression of PGR mRNACTDPMID:20864626PgrRatmethylparaben increases expressionISOPGR (Homo sapiens)6480464methylparaben results in increased expression of PGR mRNACTDPMID:17121429PgrRatmethylseleninic acid affects expressionISOPGR (Homo sapiens)6480464methylselenic acid affects the expression of PGR mRNACTDPMID:16928829PgrRatmethyltestosterone multiple interactionsEXP 6480464[Contraceptives more ...CTDPMID:10964026PgrRatmifepristone multiple interactionsISOPGR (Homo sapiens)6480464Mifepristone analog binds to and results in decreased activity of PGR protein more ...CTDPMID:15103026 more ...PgrRatmifepristone decreases expressionISOPGR (Homo sapiens)6480464Mifepristone results in decreased expression of PGR proteinCTDPMID:22266097PgrRatmifepristone multiple interactionsEXP 6480464[Mifepristone binds to and results in decreased activity of PGR protein] which results in decreased susceptibility to Progesterone more ...CTDPMID:10888668 more ...PgrRatmifepristone decreases activityISOPGR (Homo sapiens)6480464Mifepristone results in decreased activity of PGR proteinCTDPMID:15870863PgrRatmifepristone multiple interactionsISOPgr (Mus musculus)6480464Mifepristone binds to and results in decreased activity of PGR protein more ...CTDPMID:15509668 more ...PgrRatmifepristone affects activityISOPGR (Homo sapiens)6480464Mifepristone affects the activity of PGR proteinCTDPMID:1544902PgrRatMitotane multiple interactionsISOPGR (Homo sapiens)6480464Mitotane inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRatMitotane affects bindingISOPGR (Homo sapiens)6480464Mitotane binds to PGR proteinCTDPMID:14579009PgrRatmometasone furoate multiple interactionsISOPGR (Homo sapiens)6480464Mometasone Furoate binds to and results in increased activity of PGR proteinCTDPMID:15189034PgrRatmometasone furoate affects bindingISOPGR (Homo sapiens)6480464Mometasone Furoate binds to PGR proteinCTDPMID:19422381PgrRatmono(2-ethylhexyl) phthalate multiple interactionsISOPgr (Mus musculus)6480464Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased secretion of PGR protein]CTDPMID:30648648PgrRatmono(2-ethylhexyl) phthalate increases secretionISOPgr (Mus musculus)6480464mono-(2-ethylhexyl)phthalate results in increased secretion of PGR proteinCTDPMID:30648648PgrRatMonobutylphthalate increases expressionEXP 6480464monobutyl phthalate results in increased expression of PGR mRNACTDPMID:20864626PgrRatmycophenolic acid multiple interactionsISOPGR (Homo sapiens)6480464Mycophenolic Acid binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatmycotoxin increases expressionISOPGR (Homo sapiens)6480464Mycotoxins results in increased expression of PGR proteinCTDPMID:23665424PgrRatmycotoxin multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [Mycotoxins results in increased expression of PGR protein]CTDPMID:23665424PgrRatN-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide multiple interactionsISOPgr (Mus musculus)6480464N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of PGR mRNA] and N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of PGR mRNA]CTDPMID:21220312PgrRatN-acetyl-L-cysteine multiple interactionsISOPGR (Homo sapiens)6480464Acetylcysteine inhibits the reaction [SOD2 protein affects the expression of PGR mRNA]CTDPMID:18829485PgrRatN-acetyl-L-cysteine decreases secretionISOPgr (Mus musculus)6480464Acetylcysteine results in decreased secretion of PGR proteinCTDPMID:30648648PgrRatN-acetyl-L-cysteine multiple interactionsISOPgr (Mus musculus)6480464Acetylcysteine inhibits the reaction [LHB protein results in increased abundance of PGR mRNA] and Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased secretion of PGR protein]CTDPMID:21220312 and PMID:30648648PgrRatN-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal increases expressionISOPGR (Homo sapiens)6480464benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of PGR proteinCTDPMID:15218360PgrRatN-methyl-N'-nitro-N-nitrosoguanidine multiple interactionsEXP 6480464geraniol inhibits the reaction [Methylnitronitrosoguanidine results in decreased expression of PGR protein]CTDPMID:28428697PgrRatN-methyl-N'-nitro-N-nitrosoguanidine decreases expressionEXP 6480464Methylnitronitrosoguanidine results in decreased expression of PGR proteinCTDPMID:28428697PgrRatnandrolone increases expressionISOPGR (Homo sapiens)6480464Nandrolone results in increased expression of PGR mRNACTDPMID:35307500PgrRatnebivolol multiple interactionsISOPGR (Homo sapiens)6480464Nebivolol binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatnickel atom decreases expressionISOPGR (Homo sapiens)6480464Nickel results in decreased expression of PGR mRNACTDPMID:24768652 and PMID:25583101PgrRatnickel dichloride multiple interactionsISOPGR (Homo sapiens)6480464Estradiol promotes the reaction [nickel chloride results in increased expression of PGR mRNA] more ...CTDPMID:12746304PgrRatnickel dichloride increases expressionISOPGR (Homo sapiens)6480464nickel chloride results in increased expression of PGR mRNA and nickel chloride results in increased expression of PGR proteinCTDPMID:12746304PgrRatniclosamide decreases expressionISOPGR (Homo sapiens)6480464Niclosamide results in decreased expression of PGR mRNACTDPMID:36318118PgrRatnicotine decreases expressionISOPGR (Homo sapiens)6480464Nicotine results in decreased expression of PGR mRNACTDPMID:27552315PgrRatnonane increases expressionISOPGR (Homo sapiens)6480464nonane results in increased expression of PGR mRNA alternative form and nonane results in increased expression of PGR protein alternative formCTDPMID:16009159PgrRatNonylphenol increases expressionISOPgr (Mus musculus)6480464nonylphenol analog results in increased expression of PGR mRNACTDPMID:25242005PgrRatNonylphenol increases expressionEXP 6480464nonylphenol results in increased expression of PGR mRNACTDPMID:14763995PgrRatNonylphenol increases expressionISOPGR (Homo sapiens)6480464nonylphenol results in increased expression of PGR mRNA and nonylphenol results in increased expression of PGR proteinCTDPMID:20172022PgrRatNonylphenol decreases activityISOPGR (Homo sapiens)6480464nonylphenol results in decreased activity of PGR proteinCTDPMID:17304841PgrRatNonylphenol multiple interactionsISOPGR (Homo sapiens)6480464nonylphenol inhibits the reaction [Progesterone binds to PGR protein] and nonylphenol inhibits the reaction [Progesterone results in increased expression of PGR protein]CTDPMID:14579009 and PMID:18262749PgrRatNonylphenol affects bindingISOPGR (Homo sapiens)6480464nonylphenol binds to PGR proteinCTDPMID:14579009PgrRatnorethisterone multiple interactionsISOPGR (Homo sapiens)6480464Norethindrone binds to and results in increased activity of PGR proteinCTDPMID:15189034 and PMID:25752796PgrRatNorethynodrel increases expressionISOPGR (Homo sapiens)6480464Norethynodrel results in increased expression of PGR mRNACTDPMID:35307500PgrRatnorgestimate multiple interactionsISOPGR (Homo sapiens)6480464norgestimate binds to and affects the activity of PGR proteinCTDPMID:1324557 and PMID:15697108PgrRatokadaic acid decreases expressionISOPGR (Homo sapiens)6480464Okadaic Acid results in decreased expression of PGR mRNA and Okadaic Acid results in decreased expression of PGR proteinCTDPMID:15965230PgrRatonapristone multiple interactionsISOPGR (Homo sapiens)6480464onapristone binds to and results in decreased activity of PGR proteinCTDPMID:15811074PgrRatormeloxifene increases expressionEXP 6480464Centchroman results in increased expression of PGR protein and ormeloxifene results in increased expression of PGR mRNACTDPMID:15914137 and PMID:19460436PgrRatormeloxifene multiple interactionsEXP 6480464[Centchroman co-treated with Estradiol] results in decreased expression of PGR protein and ormeloxifene inhibits the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:15914137 and PMID:19460436PgrRatOsajin decreases expressionISOPGR (Homo sapiens)6480464osajin results in decreased expression of PGR mRNACTDPMID:20706672PgrRatoseltamivir multiple interactionsISOPGR (Homo sapiens)6480464Oseltamivir binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatoxaliplatin multiple interactionsISOPGR (Homo sapiens)6480464oxaliplatin binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatoxamyl multiple interactionsISOPGR (Homo sapiens)6480464oxamyl inhibits the reaction [Progesterone results in increased activity of PGR protein]CTDPMID:9126867PgrRatoxybenzone multiple interactionsISOPGR (Homo sapiens)6480464oxybenzone binds to and results in decreased activity of PGR proteinCTDPMID:15537743PgrRatoxybenzone increases expressionISOPgr (Mus musculus)6480464oxybenzone results in increased expression of PGR mRNACTDPMID:32946892PgrRatoxybenzone increases expressionISOPGR (Homo sapiens)6480464oxybenzone results in increased expression of PGR mRNACTDPMID:31939680PgrRatoxymetholone multiple interactionsISOPGR (Homo sapiens)6480464Oxymetholone binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatozone multiple interactionsISOPgr (Mus musculus)6480464[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of PGR mRNACTDPMID:34911549PgrRatp-tert-Amylphenol increases expressionEXP 64804644-tert-octylphenol results in increased expression of PGR mRNACTDPMID:14763995 and PMID:17033158PgrRatp-tert-Amylphenol increases expressionISOPGR (Homo sapiens)64804644-tert-octylphenol results in increased expression of PGR mRNACTDPMID:35307500PgrRatp-tert-Amylphenol decreases expressionISOPgr (Mus musculus)64804644-tert-octylphenol results in decreased expression of PGR mRNACTDPMID:30061528PgrRatp-tolualdehyde multiple interactionsISOPGR (Homo sapiens)64804644-methylbenzaldehyde binds to and results in decreased activity of PGR proteinCTDPMID:27633901PgrRatparacetamol multiple interactionsEXP 6480464[bisphenol A co-treated with enzacamene co-treated with octylmethoxycinnamate co-treated with butylparaben co-treated with Androgen Antagonists co-treated with Acetaminophen] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatpazopanib multiple interactionsISOPGR (Homo sapiens)6480464pazopanib binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatPCB138 multiple interactionsISOPgr (Mus musculus)6480464[2 more ...CTDPMID:25510870PgrRatpentachlorophenol decreases activityISOPGR (Homo sapiens)6480464Pentachlorophenol results in decreased activity of PGR proteinCTDPMID:17304841PgrRatpentobarbital decreases expressionEXP 6480464Pentobarbital results in decreased expression of PGR mRNACTDPMID:1840636PgrRatperfluorohexanesulfonic acid increases expressionISOPgr (Mus musculus)6480464perfluorohexanesulfonic acid results in increased expression of PGR mRNACTDPMID:37995155PgrRatperfluorooctane-1-sulfonic acid increases activityISOPGR (Homo sapiens)6480464perfluorooctane sulfonic acid results in increased activity of PGR proteinCTDPMID:27589886PgrRatperfluorooctanoic acid increases activityISOPGR (Homo sapiens)6480464perfluorooctanoic acid results in increased activity of PGR proteinCTDPMID:27589886PgrRatperfluorooctanoic acid multiple interactionsISOPGR (Homo sapiens)6480464[Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] results in decreased expression of PGR mRNACTDPMID:33325755PgrRatperfluorooctanoic acid multiple interactionsEXP 6480464[Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of PGR mRNACTDPMID:35163327PgrRatpermethrin multiple interactionsISOPGR (Homo sapiens)6480464Permethrin inhibits the reaction [Progesterone results in increased expression of PGR protein]CTDPMID:16326432PgrRatphenanthrene multiple interactionsISOPGR (Homo sapiens)6480464phenanthrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatphenol red increases expressionISOPGR (Homo sapiens)6480464Phenolsulfonphthalein results in increased expression of PGR proteinCTDPMID:3458212PgrRatPhIP multiple interactionsISOPGR (Homo sapiens)6480464fulvestrant inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of PGR protein alternative form]CTDPMID:15319301PgrRatPhIP increases expressionISOPGR (Homo sapiens)64804642-amino-1-methyl-6-phenylimidazo(4 and 5-b)pyridine results in increased expression of PGR protein alternative formCTDPMID:15319301PgrRatPhIP increases expressionEXP 64804642-amino-1-methyl-6-phenylimidazo(4 more ...CTDPMID:15637090PgrRatphorbol 13-acetate 12-myristate multiple interactionsISOPGR (Homo sapiens)6480464bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [benz(a)anthracene results in increased expression of PGR mRNA]] and Tetradecanoylphorbol Acetate inhibits the reaction [benz(a)anthracene results in increased expression of PGR mRNA]CTDPMID:22643241PgrRatphthalic acid affects bindingISOPGR (Homo sapiens)6480464phthalic acid analog binds to PGR proteinCTDPMID:14579009PgrRatphthalic acid multiple interactionsISOPGR (Homo sapiens)6480464phthalic acid analog inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:14579009PgrRatphytoestrogen increases expressionISOPGR (Homo sapiens)6480464Phytoestrogens results in increased expression of PGR mRNACTDPMID:16076101PgrRatphytoestrogen multiple interactionsISOPGR (Homo sapiens)6480464[Plasticizers co-treated with Cosmetics co-treated with Flame Retardants co-treated with perfluorooctanoic acid co-treated with Phytoestrogens] results in decreased expression of PGR mRNACTDPMID:33325755PgrRatpicene decreases expressionISOPGR (Homo sapiens)6480464picene results in decreased expression of PGR mRNACTDPMID:32251684PgrRatpicoxystrobin multiple interactionsISOPGR (Homo sapiens)6480464picoxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRatplumbagin decreases expressionEXP 6480464plumbagin results in decreased expression of PGR mRNACTDPMID:34302802PgrRatPomiferin decreases expressionISOPGR (Homo sapiens)6480464pomiferin results in decreased expression of PGR mRNACTDPMID:20706672PgrRatpotassium chloride increases activityISOPGR (Homo sapiens)6480464Potassium Chloride results in increased activity of PGR proteinCTDPMID:9879984PgrRatprochloraz multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatprocymidone multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNACTDPMID:25607892PgrRatprogesterone multiple interactionsISOPgr (Mus musculus)6480464[Estradiol co-treated with Progesterone] affects the expression of PGR protein more ...CTDPMID:15661853 more ...PgrRatprogesterone increases activityEXP 6480464Progesterone results in increased activity of PGR proteinCTDPMID:16284289 and PMID:9710597PgrRatprogesterone increases expressionISOPgr (Mus musculus)6480464Progesterone results in increased expression of PGR mRNA more ...CTDPMID:27264040 and PMID:31566189PgrRatprogesterone increases activityISOPGR (Homo sapiens)6480464Progesterone results in increased activity of PGR proteinCTDPMID:15806153 more ...PgrRatprogesterone affects localizationEXP 6480464Progesterone affects the localization of PGR proteinCTDPMID:10888668 and PMID:20726854PgrRatprogesterone decreases expressionISOPgr (Mus musculus)6480464Progesterone results in decreased expression of PGR mRNA and Progesterone results in decreased expression of PGR protein alternative formCTDPMID:22238285 and PMID:23409146PgrRatprogesterone affects bindingEXP 6480464Progesterone binds to PGR proteinCTDPMID:4375319 and PMID:7414049PgrRatprogesterone affects expressionEXP 6480464Progesterone affects the expression of PGR mRNACTDPMID:24777823PgrRatprogesterone decreases expressionISOPGR (Homo sapiens)6480464Progesterone results in decreased expression of PGR mRNA and Progesterone results in decreased expression of PGR proteinCTDPMID:22414680 more ...PgrRatprogesterone increases expressionISOPGR (Homo sapiens)6480464Progesterone results in increased expression of PGR mRNA and Progesterone results in increased expression of PGR proteinCTDPMID:16326432 more ...PgrRatprogesterone affects bindingISOPGR (Homo sapiens)6480464Progesterone binds to PGR protein and Progesterone binds to PGR protein alternative formCTDPMID:14579009 more ...PgrRatprogesterone increases expressionEXP 6480464Progesterone results in increased expression of PGR mRNACTDPMID:10888668PgrRatprogesterone multiple interactionsEXP 6480464[Estradiol co-treated with Progesterone] results in increased expression of PGR mRNA more ...CTDPMID:10888668 more ...PgrRatprogesterone affects expressionISOPgr (Mus musculus)6480464Progesterone affects the expression of PGR mRNACTDPMID:17251523PgrRatprogesterone multiple interactionsISOPGR (Homo sapiens)64804641 more ...CTDPMID:11507064 more ...PgrRatpromegestone multiple interactionsISOPGR (Homo sapiens)64804641 more ...CTDPMID:15103026 more ...PgrRatpromegestone affects bindingISOPGR (Homo sapiens)6480464Promegestone binds to PGR proteinCTDPMID:23765520PgrRatpromegestone increases uptakeISOPGR (Homo sapiens)6480464PGR protein results in increased uptake of PromegestoneCTDPMID:21795739PgrRatpromegestone multiple interactionsISOPgr (Mus musculus)6480464PGR protein promotes the reaction [Promegestone results in increased expression of FSHB mRNA]CTDPMID:16675544PgrRatpromegestone affects localizationEXP 6480464Promegestone affects the localization of PGR proteinCTDPMID:16020483PgrRatpromegestone increases activityISOPGR (Homo sapiens)6480464Promegestone results in increased activity of PGR proteinCTDPMID:15103026 more ...PgrRatpropoxur multiple interactionsISOPGR (Homo sapiens)6480464Propoxur inhibits the reaction [Progesterone results in increased activity of PGR protein]CTDPMID:9126867PgrRatpropylparaben decreases expressionISOPgr (Mus musculus)6480464propylparaben results in decreased expression of PGR mRNACTDPMID:34101200PgrRatpropylparaben increases expressionISOPGR (Homo sapiens)6480464propylparaben results in increased expression of PGR mRNACTDPMID:25128701 and PMID:31939680PgrRatpterostilbene multiple interactionsISOPGR (Homo sapiens)6480464[resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA] and [resveratrol co-treated with pterostilbene] promotes the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:27159275PgrRatpuerarin decreases expressionISOPGR (Homo sapiens)6480464puerarin results in decreased expression of PGR mRNACTDPMID:20706672PgrRatpuerarin decreases expressionEXP 6480464puerarin results in decreased expression of PGR mRNACTDPMID:22919047PgrRatpuerarin increases expressionISOPGR (Homo sapiens)6480464puerarin results in increased expression of PGR proteinCTDPMID:17142977PgrRatpurine-6-thiol increases expressionEXP 6480464Mercaptopurine results in increased expression of PGR mRNACTDPMID:23358152PgrRatpyrene multiple interactionsISOPGR (Homo sapiens)6480464pyrene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 and 20-dione results in increased activity of PGR protein]CTDPMID:26022396PgrRatpyridaben multiple interactionsISOPGR (Homo sapiens)6480464pyridaben inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRatquercetin multiple interactionsISOPGR (Homo sapiens)6480464Quercetin inhibits the reaction [Estradiol results in increased expression of PGR protein]CTDPMID:10376965PgrRatradicicol decreases expressionISOPGR (Homo sapiens)6480464monorden analog results in decreased expression of PGR protein alternative formCTDPMID:11448926PgrRatraloxifene decreases expressionISOPGR (Homo sapiens)6480464Raloxifene Hydrochloride results in decreased expression of PGR mRNA and Raloxifene Hydrochloride results in decreased expression of PGR proteinCTDPMID:11867264 more ...PgrRatraloxifene multiple interactionsISOPgr (Mus musculus)6480464[Estradiol co-treated with Raloxifene Hydrochloride] results in increased expression of PGR mRNA and Raloxifene Hydrochloride inhibits the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:26879975PgrRatraloxifene increases expressionEXP 6480464Raloxifene Hydrochloride results in increased expression of PGR proteinCTDPMID:16837883PgrRatraloxifene multiple interactionsISOPGR (Homo sapiens)6480464[Raloxifene Hydrochloride co-treated with Estradiol] results in increased expression of PGR mRNA more ...CTDPMID:21185374 and PMID:22476901PgrRatresveratrol decreases expressionISOPGR (Homo sapiens)6480464resveratrol results in decreased expression of PGR mRNA and resveratrol results in decreased expression of PGR proteinCTDPMID:11606380 and PMID:20706672PgrRatresveratrol increases expressionEXP 6480464resveratrol results in increased expression of PGR proteinCTDPMID:21248286PgrRatresveratrol decreases activityISOPGR (Homo sapiens)6480464resveratrol results in decreased activity of PGR proteinCTDPMID:11507064PgrRatresveratrol multiple interactionsISOPGR (Homo sapiens)6480464[resveratrol co-treated with pterostilbene] promotes the reaction [afimoxifene results in decreased expression of PGR mRNA] more ...CTDPMID:11507064 more ...PgrRatresveratrol decreases expressionEXP 6480464resveratrol results in decreased expression of PGR mRNACTDPMID:11218048PgrRatresveratrol increases expressionISOPGR (Homo sapiens)6480464resveratrol metabolite results in increased expression of PGR mRNA more ...CTDPMID:11606380 more ...PgrRatRosavin decreases expressionISOPGR (Homo sapiens)6480464rosavin results in decreased expression of PGR mRNACTDPMID:20706672PgrRatrotenone multiple interactionsISOPGR (Homo sapiens)6480464Rotenone binds to and results in decreased activity of PGR protein and Rotenone inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:25752796 and PMID:30818834PgrRatRU 58668 affects expressionISOPGR (Homo sapiens)6480464RU 58668 affects the expression of PGR proteinCTDPMID:15868441PgrRatrubitecan multiple interactionsISOPGR (Homo sapiens)6480464rubitecan binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatS-methyl methanethiosulfonate decreases activityISOPGR (Homo sapiens)6480464methyl methanethiosulfonate results in decreased activity of PGR proteinCTDPMID:9879984PgrRatSe-methyl-L-selenocysteine decreases expressionISOPGR (Homo sapiens)6480464selenomethylselenocysteine results in decreased expression of PGR proteinCTDPMID:18855134PgrRatSe-methyl-L-selenocysteine multiple interactionsISOPGR (Homo sapiens)6480464[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR proteinCTDPMID:18855134PgrRatSe-methylselenocysteine decreases expressionISOPGR (Homo sapiens)6480464selenomethylselenocysteine results in decreased expression of PGR proteinCTDPMID:18855134PgrRatSe-methylselenocysteine multiple interactionsISOPGR (Homo sapiens)6480464[selenomethylselenocysteine co-treated with Tamoxifen] results in decreased expression of PGR proteinCTDPMID:18855134PgrRatsilicon dioxide decreases expressionISOPgr (Mus musculus)6480464Silicon Dioxide results in decreased expression of PGR mRNACTDPMID:29341224PgrRatsilver atom increases expressionISOPgr (Mus musculus)6480464Silver results in increased expression of PGR mRNACTDPMID:27131904PgrRatsilver atom multiple interactionsISOPGR (Homo sapiens)6480464Silver inhibits the reaction [butylparaben results in increased expression of PGR mRNA] and Silver inhibits the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:29074358PgrRatsilver(0) increases expressionISOPgr (Mus musculus)6480464Silver results in increased expression of PGR mRNACTDPMID:27131904PgrRatsilver(0) multiple interactionsISOPGR (Homo sapiens)6480464Silver inhibits the reaction [butylparaben results in increased expression of PGR mRNA] and Silver inhibits the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:29074358PgrRatsimazine multiple interactionsEXP 6480464Simazine inhibits the reaction [Progesterone binds to PGR protein]CTDPMID:8812239PgrRatsodium arsenite affects activityISOPGR (Homo sapiens)6480464sodium arsenite affects the activity of PGR proteinCTDPMID:17173375PgrRatsodium arsenite decreases expressionISOPgr (Mus musculus)6480464sodium arsenite results in decreased expression of PGR mRNACTDPMID:37682722PgrRatsodium arsenite decreases expressionISOPGR (Homo sapiens)6480464sodium arsenite results in decreased expression of PGR mRNA and sodium arsenite results in decreased expression of PGR proteinCTDPMID:25728338 and PMID:37269932PgrRatsodium arsenite decreases activityISOPGR (Homo sapiens)6480464sodium arsenite results in decreased activity of PGR proteinCTDPMID:9879984PgrRatsodium arsenite multiple interactionsISOPGR (Homo sapiens)6480464sodium arsenite inhibits the reaction [Estradiol results in increased expression of PGR mRNA] and sodium arsenite inhibits the reaction [Estradiol results in increased expression of PGR protein]CTDPMID:25728338PgrRatsodium chloride increases activityISOPGR (Homo sapiens)6480464Sodium Chloride results in increased activity of PGR proteinCTDPMID:9879984PgrRatsodium fluoride increases expressionEXP 6480464Sodium Fluoride results in increased expression of PGR proteinCTDPMID:24071475PgrRatsophoraflavanone B increases expressionISOPGR (Homo sapiens)64804648-prenylnaringenin results in increased expression of PGR mRNACTDPMID:16076101PgrRatsophoraflavanone B multiple interactionsEXP 6480464Fulvestrant inhibits the reaction [8-prenylnaringenin results in increased expression of PGR mRNA]CTDPMID:34848279PgrRatsophoraflavanone B increases expressionEXP 64804648-prenylnaringenin results in increased expression of PGR mRNA and 8-prenylnaringenin results in increased expression of PGR proteinCTDPMID:16522720 more ...PgrRatSophoricoside increases expressionISOPgr (Mus musculus)6480464sophoricoside results in increased expression of PGRCTDPMID:24877640PgrRatstaurosporine multiple interactionsISOPGR (Homo sapiens)6480464Staurosporine binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatstilben-4-ol increases expressionISOPGR (Homo sapiens)64804644-hydroxystilbene results in increased expression of PGR mRNACTDPMID:19496085PgrRatstilbene-4,4'-diol increases expressionISOPGR (Homo sapiens)64804644 and 4'-dihydroxystilbene results in increased expression of PGR mRNACTDPMID:19496085PgrRatsulindac sulfide decreases expressionISOPGR (Homo sapiens)6480464sulindac sulfide results in decreased expression of PGR mRNA and sulindac sulfide results in decreased expression of PGR proteinCTDPMID:16740773PgrRatsulindac sulfone decreases expressionISOPGR (Homo sapiens)6480464sulindac sulfone results in decreased expression of PGR mRNA and sulindac sulfone results in decreased expression of PGR proteinCTDPMID:16740773PgrRatsunitinib multiple interactionsISOPGR (Homo sapiens)6480464sunitinib binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatsunitinib decreases expressionISOPGR (Homo sapiens)6480464Sunitinib results in decreased expression of PGR mRNACTDPMID:31533062PgrRatT-2 toxin multiple interactionsISOPGR (Homo sapiens)6480464T-2 Toxin inhibits the reaction [[CGA protein co-treated with FSHB protein] results in increased expression of PGR mRNA]CTDPMID:30951242PgrRattamoxifen multiple interactionsISOPGR (Homo sapiens)6480464[bisphenol A co-treated with Tamoxifen] results in increased expression of PGR mRNA more ...CTDPMID:18855134 more ...PgrRattamoxifen increases expressionISOPGR (Homo sapiens)6480464Tamoxifen results in increased expression of PGR mRNA and Tamoxifen results in increased expression of PGR proteinCTDPMID:16002280 more ...PgrRattamoxifen multiple interactionsEXP 6480464[Estradiol co-treated with Tamoxifen] results in increased expression of PGR protein and Tamoxifen inhibits the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:12834913 and PMID:19460436PgrRattamoxifen increases expressionEXP 6480464Tamoxifen results in increased expression of PGR mRNA and Tamoxifen results in increased expression of PGR proteinCTDPMID:11748029 more ...PgrRattamoxifen increases expressionISOPgr (Mus musculus)6480464Tamoxifen results in increased expression of PGR mRNACTDPMID:21138602PgrRattamoxifen decreases expressionISOPGR (Homo sapiens)6480464Tamoxifen analog results in decreased expression of PGR protein more ...CTDPMID:18997820 more ...PgrRattamoxifen increases response to substanceISOPGR (Homo sapiens)6480464PGR protein results in increased susceptibility to TamoxifenCTDPMID:16000581PgrRattamoxifen affects response to substanceISOPGR (Homo sapiens)6480464PGR protein affects the susceptibility to TamoxifenCTDPMID:15832264 and PMID:18425577PgrRattanespimycin decreases expressionISOPgr (Mus musculus)6480464tanespimycin results in decreased expression of PGR proteinCTDPMID:11448926PgrRattea tree oil increases expressionISOPGR (Homo sapiens)6480464Tea Tree Oil results in increased expression of PGR mRNACTDPMID:31393563PgrRattea tree oil multiple interactionsISOPGR (Homo sapiens)6480464Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]CTDPMID:31393563PgrRattegaserod multiple interactionsISOPGR (Homo sapiens)6480464tegaserod binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatTemsirolimus multiple interactionsISOPGR (Homo sapiens)6480464temsirolimus binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRatteniposide multiple interactionsISOPGR (Homo sapiens)6480464Teniposide binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRattestosterone increases expressionISOPGR (Homo sapiens)6480464Testosterone results in increased expression of PGR mRNACTDPMID:33728745PgrRattestosterone multiple interactionsISOPGR (Homo sapiens)6480464Testosterone binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRatTestosterone propionate decreases expressionEXP 6480464Testosterone Propionate results in decreased expression of PGR proteinCTDPMID:23669243PgrRatTestosterone propionate decreases expressionISOPgr (Mus musculus)6480464Testosterone Propionate results in decreased expression of PGR mRNACTDPMID:17574608PgrRatTestosterone propionate increases expressionEXP 6480464Testosterone Propionate results in increased expression of PGR proteinCTDPMID:23669243PgrRatTetrachlorobisphenol A increases expressionISOPGR (Homo sapiens)6480464tetrachlorodian results in increased expression of PGR mRNA and tetrachlorodian results in increased expression of PGR proteinCTDPMID:12753421 and PMID:33582643PgrRatTetrachlorobisphenol A decreases expressionISOPGR (Homo sapiens)6480464tetrachlorodian results in decreased expression of PGR mRNACTDPMID:36190352PgrRattetraphene multiple interactionsISOPGR (Homo sapiens)6480464bisindolylmaleimide I inhibits the reaction [Tetradecanoylphorbol Acetate inhibits the reaction [benz(a)anthracene results in increased expression of PGR mRNA]] and Tetradecanoylphorbol Acetate inhibits the reaction [benz(a)anthracene results in increased expression of PGR mRNA]CTDPMID:22643241PgrRattetraphene increases expressionISOPGR (Homo sapiens)6480464benz(a)anthracene results in increased expression of PGR mRNACTDPMID:22643241PgrRattibolone increases activityISOPGR (Homo sapiens)6480464tibolone metabolite results in increased activity of PGR protein and tibolone results in increased activity of PGR proteinCTDPMID:16011840PgrRatticlopidine multiple interactionsISOPGR (Homo sapiens)6480464Ticlopidine binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRattolcapone multiple interactionsISOPGR (Homo sapiens)6480464tolcapone binds to and results in decreased activity of PGR proteinCTDPMID:25752796PgrRattoxaphene multiple interactionsISOPGR (Homo sapiens)6480464Toxaphene inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3 more ...CTDPMID:14579009 and PMID:26022396PgrRattoxaphene increases expressionEXP 6480464Toxaphene results in increased expression of PGR mRNACTDPMID:10774817PgrRattoxaphene affects bindingISOPGR (Homo sapiens)6480464Toxaphene binds to PGR proteinCTDPMID:14579009PgrRatTRAM-34 increases expressionISOPGR (Homo sapiens)6480464TRAM 34 results in increased expression of PGR mRNACTDPMID:20050851PgrRattrans-stilbene-4,4'-diol increases expressionISOPGR (Homo sapiens)64804644 and 4'-dihydroxystilbene results in increased expression of PGR mRNACTDPMID:19496085PgrRattriamcinolone multiple interactionsISOPGR (Homo sapiens)6480464Triamcinolone binds to and results in increased activity of PGR proteinCTDPMID:25752796PgrRattrichostatin A multiple interactionsISOPGR (Homo sapiens)6480464[Decitabine co-treated with trichostatin A] affects the expression of PGR mRNA more ...CTDPMID:16024066 more ...PgrRattrichostatin A increases expressionISOPGR (Homo sapiens)6480464trichostatin A results in increased expression of PGR mRNA more ...CTDPMID:16024066 more ...PgrRattrichostatin A multiple interactionsISOPgr (Mus musculus)6480464[estradiol dipropionate co-treated with trichostatin A] results in decreased expression of PGR proteinCTDPMID:15930180PgrRattrifloxystrobin multiple interactionsISOPGR (Homo sapiens)6480464trifloxystrobin inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRattrimegestone multiple interactionsISOPGR (Homo sapiens)6480464trimegestone promotes the reaction [PGR protein binds to NCOA1 protein]CTDPMID:15937332PgrRattriphenyl phosphate multiple interactionsISOPGR (Homo sapiens)6480464triphenyl phosphate binds to and results in decreased activity of PGR proteinCTDPMID:23398518PgrRattriptonide increases expressionISOPgr (Mus musculus)6480464triptonide results in increased expression of PGR mRNACTDPMID:33045310PgrRattris(2-butoxyethyl) phosphate multiple interactionsISOPGR (Homo sapiens)6480464tris(2-butoxyethyl) phosphate binds to and results in decreased activity of PGR proteinCTDPMID:23398518PgrRatursodeoxycholic acid multiple interactionsEXP 6480464Ursodeoxycholic Acid inhibits the reaction [[Ethinyl Estradiol co-treated with Progesterone] results in increased expression of PGR protein]CTDPMID:14728856PgrRatvalproic acid multiple interactionsISOPGR (Homo sapiens)6480464Valproic Acid promotes the reaction [Estradiol results in increased expression of PGR mRNA]CTDPMID:19772891PgrRatvalproic acid affects expressionISOPGR (Homo sapiens)6480464Valproic Acid affects the expression of PGR mRNACTDPMID:25979313PgrRatvalproic acid increases methylationISOPGR (Homo sapiens)6480464Valproic Acid results in increased methylation of PGR geneCTDPMID:29154799PgrRatvalproic acid affects expressionISOPgr (Mus musculus)6480464Valproic Acid affects the expression of PGR mRNACTDPMID:17292431 and PMID:17963808PgrRatvinclozolin multiple interactionsEXP 6480464[Dibutyl Phthalate co-treated with Diethylhexyl Phthalate co-treated with vinclozolin co-treated with prochloraz co-treated with procymidone co-treated with Linuron co-treated with epoxiconazole co-treated with Dichlorodiphenyl Dichloroethylene] results in decreased expression of PGR mRNA and [Genistein co-treated with vinclozolin] affects the expression of PGR mRNACTDPMID:23410115 and PMID:25607892PgrRatvinclozolin increases expressionEXP 6480464vinclozolin results in increased expression of PGR mRNACTDPMID:29863768PgrRatvinclozolin decreases expressionEXP 6480464vinclozolin results in decreased expression of PGR mRNACTDPMID:23160963PgrRatvinclozolin increases expressionISOPgr (Mus musculus)6480464vinclozolin results in increased expression of PGR mRNACTDPMID:16504050PgrRatvinclozolin multiple interactionsISOPGR (Homo sapiens)6480464vinclozolin binds to and results in decreased activity of PGR protein more ...CTDPMID:14579009 more ...PgrRatvinclozolin affects bindingISOPGR (Homo sapiens)6480464vinclozolin binds to PGR proteinCTDPMID:14579009PgrRatvinclozolin affects expressionEXP 6480464vinclozolin affects the expression of PGR mRNACTDPMID:23410115PgrRatvorinostat multiple interactionsISOPGR (Homo sapiens)6480464Vorinostat inhibits the reaction [Promegestone results in increased activity of PGR protein]CTDPMID:30818834PgrRatwortmannin decreases reactionEXP 152177689wortmannin inhibits the reaction [estrogen increases expression of Pgr mRNA] in rat uterusRGD PgrRatXL147 multiple interactionsISOPgr (Mus musculus)6480464[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of PGR mRNACTDPMID:27935865PgrRatzearalenone increases expressionISOPGR (Homo sapiens)6480464Zearalenone results in increased expression of PGR mRNA and Zearalenone results in increased expression of PGR proteinCTDPMID:19371625 more ...PgrRatzearalenone multiple interactionsISOPGR (Homo sapiens)6480464deoxynivalenol promotes the reaction [Zearalenone results in increased expression of PGR mRNA] more ...CTDPMID:21803136 and PMID:35588983PgrRatzidovudine multiple interactionsISOPGR (Homo sapiens)6480464[Zidovudine co-treated with IFNA1 protein] results in decreased expression of PGR mRNACTDPMID:20370541PgrRatzinc oxide decreases expressionISOPgr (Mus musculus)6480464Zinc Oxide results in decreased expression of PGR mRNACTDPMID:33599401
Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PgrRatcellular response to estrogen stimulus  IEP 152177689 RGD PgrRatcellular response to follicle-stimulating hormone stimulus  IEP 1601291 RGD PgrRatcellular response to gonadotropin stimulus  IEP 1601291 RGD PgrRatcellular response to luteinizing hormone stimulus  IEP 1601291 RGD PgrRatcellular response to wortmannin  IEP 152177689 RGD PgrRatditerpenoid metabolic process  IEP 1601291forskolin and phorbol 12-myristate 13-acetateRGD PgrRatepithelial cell maturation acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:1857933 PMID:14765981RGDPMID:14765981PgrRatestrous cycle  IEP 7248717 RGD PgrRatfemale mating behavior  IMP 7248715 RGD PgrRatglandular epithelial cell maturation involved_inIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatglandular epithelial cell maturation acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:1857933 PMID:14765981RGDPMID:14765981PgrRatlung alveolus development involved_inIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatlung alveolus development acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:3032652 PMID:24190884RGDPMID:24190884PgrRatluteinization  IEP 1601291 RGD PgrRatmaintenance of protein location in nucleus involved_inIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatmaintenance of protein location in nucleus involved_inISOPGR (Homo sapiens)1624291 PMID:20861224RGDPMID:20861224PgrRatmammary gland development acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:1857933 more ...RGDPMID:12897242 and PMID:14765981PgrRatnegative regulation of apoptotic process  IMP 7248712update to cell specific termRGD PgrRatnegative regulation of DNA-templated transcription  IEP 729543 RGD PgrRatnegative regulation of gene expression involved_inISOPGR (Homo sapiens)1624291 PMID:21695196RGDPMID:21695196PgrRatnegative regulation of gene expression involved_inIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatnegative regulation of granulosa cell apoptotic process  IMP 10401186 RGD PgrRatnuclear receptor-mediated steroid hormone signaling pathway involved_inIBAMGI:88064 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033PgrRatovulation from ovarian follicle involved_inIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatovulation from ovarian follicle acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:2674932 PMID:12897242RGDPMID:12897242PgrRatparacrine signaling involved_inIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatparacrine signaling acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:3032652 PMID:24190884RGDPMID:24190884PgrRatpositive regulation of cell population proliferation  IDA 7248707 RGD PgrRatpositive regulation of DNA-templated transcription  IDA 1601291 RGD PgrRatpositive regulation of smooth muscle cell migration  IMP 7248703 RGD PgrRatpositive regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatpositive regulation of transcription by RNA polymerase II involved_inISOPGR (Homo sapiens)1624291 PMID:17785366RGDPMID:17785366PgrRatprogesterone receptor signaling pathway involved_inIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatprogesterone receptor signaling pathway acts_upstream_of_or_withinISOPgr (Mus musculus)1624291 PMID:16176985RGDPMID:16176985PgrRatprogesterone receptor signaling pathway involved_inISOPGR (Homo sapiens)1624291 PMID:10757795 and PMID:9620806RGDPMID:10757795 and PMID:9620806PgrRatregulation of DNA-templated transcription involved_inISOPGR (Homo sapiens)1624291 PMID:20861224RGDPMID:20861224PgrRatregulation of DNA-templated transcription acts_upstream_of_or_withinISOPgr (Mus musculus)1624291 PMID:14681235RGDPMID:14681235PgrRatregulation of epithelial cell proliferation involved_inIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatregulation of epithelial cell proliferation acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:2674932 PMID:12897242RGDPMID:12897242PgrRatregulation of transcription by RNA polymerase II involved_inIBAFB:FBgn0035849 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033PgrRatresponse to cocaine  IDA 7248706 RGD PgrRatresponse to estrogen  IEP 7248701 RGD PgrRatresponse to progesterone  IEP 7248701 RGD PgrRatsmooth muscle relaxation of the bladder outlet involved_inISOPGR (Sus scrofa)1624291 PMID:24296318RGDPMID:24296318PgrRattertiary branching involved in mammary gland duct morphogenesis involved_inIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRattertiary branching involved in mammary gland duct morphogenesis acts_upstream_of_or_withinISOPgr (Mus musculus)1624291MGI:1857933 PMID:10733525RGDPMID:10733525

Cellular Component

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PgrRataxon  IDA 7248705 RGD PgrRataxon terminus  IDA 7248705 RGD PgrRatchromatin part_ofIBAPANTHER:PTN002377694 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033PgrRatchromatin part_ofISOPGR (Homo sapiens)1624291 PMID:37478846RGDPMID:37478846PgrRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044PgrRatdendrite  IDA 7248705 RGD PgrRatdendritic spine  IDA 7248705 RGD PgrRatnucleus located_inISOPGR (Canis lupus familiaris)1624291 PMID:11282275RGDPMID:11282275PgrRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044PgrRatperikaryon  IDA 7248705 RGD PgrRatplasma membrane located_inIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatplasma membrane is_active_inISOPGR (Homo sapiens)1624291 PMID:22031296RGDPMID:22031296

Molecular Function

  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PgrRatATPase binding enablesISOPGR (Homo sapiens)1624291 PMID:12058073RGDPMID:12058073PgrRatATPase binding enablesIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOPGR (Homo sapiens)1624291 PMID:17785366RGDPMID:17785366PgrRatenzyme binding enablesISOPGR (Homo sapiens)1624291UniProtKB:P55345 and PMID:12039952RGDPMID:12039952PgrRatestrogen response element binding enablesIBAMGI:1347056 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033PgrRathormone binding  IMP 1601290 RGD PgrRatidentical protein binding enablesIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatidentical protein binding enablesISOPGR (Homo sapiens)1624291UniProtKB:P06401 more ...RGDPMID:17277083 and PMID:24909783PgrRatnuclear receptor activity enablesISOPGR (Homo sapiens)1624291 PMID:10757795 and PMID:9620806RGDPMID:10757795 and PMID:9620806PgrRatnuclear receptor activity enablesISOPgr (Mus musculus)1624291 PMID:14681235RGDPMID:14681235PgrRatnuclear receptor activity enablesIBAFB:FBgn0264562 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033PgrRatnuclear receptor activity enablesIEAUniProtKB:Q00175 and ensembl:ENSMUSP000001401241600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatnuclear steroid receptor activity  IMP 1601290 RGD PgrRatnuclear steroid receptor activity enablesISOPgr (Mus musculus)1624291 PMID:16176985RGDPMID:16176985PgrRatnuclear steroid receptor activity enablesIEAUniRule:UR0015047811600115GO_REF:0000104UniProtGO_REF:0000104PgrRatprotein binding  IPIEsr2 (Rattus norvegicus)7248707 RGD PgrRatprotein binding enablesISOPGR (Homo sapiens)1624291UniProtKB:O95071 more ...RGDPMID:12011095 more ...PgrRatprotein binding enablesISOPGR (Homo sapiens) and UniProtKB:P06401-11624291UniProtKB:P03372 and PMID:12612073RGDPMID:12612073PgrRatprotein binding enablesISOPgr (Mus musculus)1624291UniProtKB:P19785 more ...RGDMGI:5437422 more ...PgrRatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRatRNA polymerase II cis-regulatory region sequence-specific DNA binding enablesISOPGR (Homo sapiens)1624291 PMID:17785366RGDPMID:17785366PgrRatsequence-specific DNA binding  IDA 7248706 RGD PgrRatsignaling receptor binding enablesISOPGR (Homo sapiens) and UniProtKB:P06401-11624291UniProtKB:P51843 and PMID:12771131RGDPMID:12771131PgrRatsteroid binding  IMP 1601290 RGD PgrRatsteroid binding enablesIEAUniRule:UR0015047811600115GO_REF:0000104UniProtGO_REF:0000104PgrRattranscription coactivator binding enablesIEAUniProtKB:P06401 and ensembl:ENSP000003251201600115GO_REF:0000107EnsemblGO_REF:0000107PgrRattranscription coactivator binding enablesISOPGR (Homo sapiens)1624291UniProtKB:Q96PN7 and PMID:17015480RGDPMID:17015480PgrRatzinc ion binding enablesIEAInterPro:IPR001628 and InterPro:IPR0130881600115GO_REF:0000002InterProGO_REF:0000002PgrRatzinc ion binding enablesIEAUniRule:UR0015047811600115GO_REF:0000104UniProtGO_REF:0000104

Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)PgrRatphosphatidylinositol 3-kinase-Akt signaling pathway   IMP 152177689 RGD 
Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rh1  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-(3-(trifluoromethyl)phenyl)piperazine  (ISO)
1-benzylpiperazine  (ISO)
1-Hydroxypyrene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2-(2-Chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,3',4,4',5,5'-Heptachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-Trimethylbenzaldehyde  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-palmitoylglycerol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,5-di-tert-Butyl-4-hydroxybenzaldehyde  (ISO)
3,6-diaminoacridine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-methylcholanthrene  (EXP,ISO)
4'-epidoxorubicin  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-nonylphenol  (EXP,ISO)
4-terpineol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-oxocampestanol  (ISO)
8-Br-cAMP  (ISO)
adefovir pivoxil  (ISO)
afimoxifene  (ISO)
alachlor  (ISO)
aldicarb  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-Methylstyrene  (ISO)
alpha-naphthoflavone  (ISO)
alpha-Zearalanol  (EXP,ISO)
alternariol  (ISO)
aminoglutethimide  (ISO)
amlodipine  (ISO)
ammonium sulfate  (ISO)
amsacrine  (ISO)
anastrozole  (ISO)
androgen antagonist  (EXP)
apigenin  (ISO)
aprepitant  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
artesunate  (ISO)
atrazine  (EXP,ISO)
bendiocarb  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (EXP,ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol A dimethacrylate  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
budesonide  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
Butylparaben  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
camphor  (ISO)
camptothecin  (ISO)
carbaryl  (ISO)
carbon nanotube  (ISO)
carfilzomib  (ISO)
chlordecone  (EXP,ISO)
chlorogenic acid  (ISO)
chlorpyrifos  (EXP,ISO)
Chorionic gonadotropin  (ISO)
chrysen-6-ol  (ISO)
Ciclesonide  (ISO)
ciclopirox  (ISO)
clomiphene  (ISO)
cobalt dichloride  (ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (ISO)
copper(II) chloride  (ISO)
coumestrol  (EXP,ISO)
Cuprizon  (EXP)
cyclohexanone  (ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
daidzein  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
danazol  (ISO)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (ISO)
delta-hexachlorocyclohexane  (ISO)
deoxynivalenol  (ISO)
desogestrel  (ISO)
diarylheptanoid  (ISO)
dibutyl phthalate  (EXP,ISO)
dichloroacetic acid  (ISO)
dieldrin  (EXP,ISO)
diethyl phthalate  (EXP,ISO)
diethylstilbestrol  (EXP,ISO)
difenoconazole  (ISO)
digitoxin  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (EXP,ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
drospirenone  (ISO)
dydrogesterone  (ISO)
elcometrine  (ISO)
emetine  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enzacamene  (EXP,ISO)
epoxiconazole  (EXP)
erucamide  (ISO)
Estradiol dipropionate  (ISO)
estriol  (ISO)
estrogen  (EXP)
estrone  (ISO)
ethanol  (EXP)
ethyl myristate  (ISO)
ethylparaben  (ISO)
etonogestrel  (ISO)
etoposide phosphate  (ISO)
exemestane  (ISO)
ezetimibe  (ISO)
fenhexamid  (ISO)
fenpyroximate  (ISO)
fenvalerate  (ISO)
fludioxonil  (ISO)
flumethrin  (ISO)
flunisolide  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
fluticasone  (ISO)
flutolanil  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-terpinene  (ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
geraniol  (EXP)
gestodene  (ISO)
ginsenoside Rb1  (ISO)
ginsenoside Re  (ISO)
ginsenoside Rg1  (ISO)
glutathione  (ISO)
glyceollin  (ISO)
glyphosate  (EXP,ISO)
Goserelin  (ISO)
heptachlor  (EXP,ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (ISO)
hydrogen peroxide  (ISO)
icariin  (ISO)
Icaritin  (ISO)
ICI-164384  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
irilone  (ISO)
Isobavachin  (ISO)
Isobutylparaben  (EXP)
isoflavones  (EXP)
isophorone  (ISO)
Isopropylparaben  (EXP)
isoprothiolane  (ISO)
kaempferol  (ISO)
ketoconazole  (ISO)
kresoxim-methyl  (ISO)
lasofoxifene  (EXP)
Laurolactam  (ISO)
lead(II) chloride  (ISO)
letrozole  (ISO)
levonorgestrel  (ISO)
limonene  (ISO)
linalool  (ISO)
linalyl acetate  (ISO)
linuron  (EXP)
loteprednol etabonate  (ISO)
medroxyprogesterone  (ISO)
medroxyprogesterone acetate  (ISO)
megestrol acetate  (ISO)
melatonin  (EXP,ISO)
mercaptopurine  (EXP)
mercury dichloride  (ISO)
mestranol  (ISO)
methimazole  (ISO)
methomyl  (ISO)
methotrexate  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
methylmercury chloride  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (EXP)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
mometasone furoate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (EXP)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
nandrolone  (ISO)
nebivolol  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
niclosamide  (ISO)
nicotine  (ISO)
nonane  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
Norethynodrel  (ISO)
norgestimate  (ISO)
okadaic acid  (ISO)
onapristone  (ISO)
ormeloxifene  (EXP)
Osajin  (ISO)
oseltamivir  (ISO)
oxaliplatin  (ISO)
oxamyl  (ISO)
oxybenzone  (ISO)
oxymetholone  (ISO)
ozone  (ISO)
p-tert-Amylphenol  (EXP,ISO)
p-tolualdehyde  (ISO)
paracetamol  (EXP)
pazopanib  (ISO)
PCB138  (ISO)
pentachlorophenol  (ISO)
pentobarbital  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenol red  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picene  (ISO)
picoxystrobin  (ISO)
plumbagin  (EXP)
Pomiferin  (ISO)
potassium chloride  (ISO)
prochloraz  (EXP)
procymidone  (EXP)
progesterone  (EXP,ISO)
promegestone  (EXP,ISO)
propoxur  (ISO)
propylparaben  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
purine-6-thiol  (EXP)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
radicicol  (ISO)
raloxifene  (EXP,ISO)
resveratrol  (EXP,ISO)
Rosavin  (ISO)
rotenone  (ISO)
RU 58668  (ISO)
rubitecan  (ISO)
S-methyl methanethiosulfonate  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
sophoraflavanone B  (EXP,ISO)
Sophoricoside  (ISO)
staurosporine  (ISO)
stilben-4-ol  (ISO)
stilbene-4,4'-diol  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tea tree oil  (ISO)
tegaserod  (ISO)
Temsirolimus  (ISO)
teniposide  (ISO)
testosterone  (ISO)
Testosterone propionate  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetraphene  (ISO)
tibolone  (ISO)
ticlopidine  (ISO)
tolcapone  (ISO)
toxaphene  (EXP,ISO)
TRAM-34  (ISO)
trans-stilbene-4,4'-diol  (ISO)
triamcinolone  (ISO)
trichostatin A  (ISO)
trifloxystrobin  (ISO)
trimegestone  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vorinostat  (ISO)
wortmannin  (EXP)
XL147  (ISO)
zearalenone  (ISO)
zidovudine  (ISO)
zinc oxide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (IEP)
cellular response to follicle-stimulating hormone stimulus  (IEP)
cellular response to gonadotropin stimulus  (IEP)
cellular response to luteinizing hormone stimulus  (IEP)
cellular response to wortmannin  (IEP)
diterpenoid metabolic process  (IEP)
epithelial cell maturation  (ISO)
estrous cycle  (IEP)
female mating behavior  (IMP)
glandular epithelial cell maturation  (IEA,ISO)
lung alveolus development  (IEA,ISO)
luteinization  (IEP)
maintenance of protein location in nucleus  (IEA,ISO)
mammary gland development  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of DNA-templated transcription  (IEP)
negative regulation of gene expression  (IEA,ISO)
negative regulation of granulosa cell apoptotic process  (IMP)
nuclear receptor-mediated steroid hormone signaling pathway  (IBA)
ovulation from ovarian follicle  (IEA,ISO)
paracrine signaling  (IEA,ISO)
positive regulation of cell population proliferation  (IDA)
positive regulation of DNA-templated transcription  (IDA)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
progesterone receptor signaling pathway  (IEA,ISO)
regulation of DNA-templated transcription  (ISO)
regulation of epithelial cell proliferation  (IEA,ISO)
regulation of transcription by RNA polymerase II  (IBA)
response to cocaine  (IDA)
response to estrogen  (IEP)
response to progesterone  (IEP)
smooth muscle relaxation of the bladder outlet  (ISO)
tertiary branching involved in mammary gland duct morphogenesis  (IEA,ISO)

Cellular Component
axon  (IDA)
axon terminus  (IDA)
chromatin  (IBA,ISO)
cytoplasm  (IEA)
dendrite  (IDA)
dendritic spine  (IDA)
nucleus  (IEA,ISO)
perikaryon  (IDA)
plasma membrane  (IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Differential responses of progesterone receptor membrane component-1 (Pgrmc1) and the classical progesterone receptor (Pgr) to 17beta-estradiol and progesterone in hippocampal subregions that support synaptic remodeling and neurogenesis. Bali N, etal., Endocrinology. 2012 Feb;153(2):759-69. doi: 10.1210/en.2011-1699. Epub 2011 Dec 6.
2. Role of the progesterone receptor in restrained glutamic acid decarboxylase gene expression in the hypothalamus during the preovulatory luteinizing hormone surge. Brann DW, etal., Neuroendocrinology 2002 Nov;76(5):283-9.
3. Progestin receptors mediate progesterone suppression of epileptiform activity in tetanized hippocampal slices in vitro. Edwards HE, etal., Neuroscience. 2000;101(4):895-906.
4. Dominant role of nuclear progesterone receptor in the control of rat periovulatory granulosa cell apoptosis. Friberg PA, etal., Biol Reprod. 2009 Jun;80(6):1160-7. doi: 10.1095/biolreprod.108.073932. Epub 2009 Feb 4.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
7. Antagonists of the protein kinase A and mitogen-activated protein kinase systems and of the progestin receptor block the ability of vaginocervical/flank-perineal stimulation to induce female rat sexual behaviour. Gonzalez-Flores O, etal., J Neuroendocrinol. 2008 Dec;20(12):1361-7. doi: 10.1111/j.1365-2826.2008.01794.x.
8. Sex differences in the regulation of progesterone receptor isoforms expression in the rat brain. Guerra-Araiza C, etal., Brain Res Bull 2002 Oct 30;59(2):105-9.
9. Changes in alpha-estradiol receptor and progesterone receptor expression in the locus coeruleus and preoptic area throughout the rat estrous cycle. Helena CV, etal., J Endocrinol. 2006 Feb;188(2):155-65.
10. PROGINS Alu sequence insertion is associated with hyperprolactinaemia but not leiomyoma susceptibility. Hsieh YY, etal., Clin Endocrinol (Oxf). 2005 Apr;62(4):492-7.
11. Extra-nuclear activation of progesterone receptor in regulating arterial smooth muscle cell migration. Hsu SP, etal., Atherosclerosis. 2011 Jul;217(1):83-9. doi: 10.1016/j.atherosclerosis.2011.02.051. Epub 2011 Mar 10.
12. Estrogen-induced activation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor expression, and edema in the uterus are mediated by the phosphatidylinositol 3-kinase/Akt pathway. Kazi AA and Koos RD, Endocrinology. 2007 May;148(5):2363-74. doi: 10.1210/en.2006-1394. Epub 2007 Feb 1.
13. Cloning of the rat progesterone receptor gene 5'-region and identification of two functionally distinct promoters. Kraus WL, etal., Mol Endocrinol 1993 Dec;7(12):1603-16.
14. Immunocytochemical evidence for a progesterone receptor in neurons and glial cells of the rat spinal cord. Labombarda F, etal., Neurosci Lett. 2000 Jul 7;288(1):29-32.
15. Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury. Meffre D, etal., Neuroscience. 2013 Feb 12;231:111-24. doi: 10.1016/j.neuroscience.2012.11.039. Epub 2012 Dec 2.
16. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
17. Site-specific decrease of progesterone receptor mRNA expression in the hypothalamus of middle-aged persistently estrus rats. Mills RH, etal., Brain Res 2002 Nov 15;955(1-2):200-6.
18. Hormonal regulation, localization, and functional activity of the progesterone receptor in granulosa cells of rat preovulatory follicles. Natraj U and Richards JS, Endocrinology. 1993 Aug;133(2):761-9.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. Regulation of the progesterone receptor gene by gonadotropins and cyclic adenosine 3',5'-monophosphate in rat granulosa cells. Park-Sarge OK and Mayo KE, Endocrinology 1994 Feb;134(2):709-18.
22. Biological markers that predict clinical recurrence in ductal carcinoma in situ of the breast. Provenzano E, etal., Eur J Cancer. 2003 Mar;39(5):622-30.
23. Sex differences in progesterone receptor expression: a potential mechanism for estradiol-mediated sexual differentiation. Quadros PS, etal., Endocrinology 2002 Oct;143(10):3727-39.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Association between polymorphisms in the progesterone receptor gene and endometriosis. Treloar SA, etal., Mol Hum Reprod. 2005 Sep;11(9):641-7. Epub 2005 Aug 26.
27. Progesterone regulation of the progesterone receptor in rat gonadotropes. Turgeon JL and Waring DW, Endocrinology. 2000 Sep;141(9):3422-9.
28. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Vallejo G, etal., Mol Endocrinol. 2005 Dec;19(12):3023-37. Epub 2005 Jul 14.
29. Correlates of obesity in postmenopausal women with breast cancer: comparison of genetic, demographic, disease-related, life history and dietary factors. Wasserman L, etal., Int J Obes Relat Metab Disord. 2004 Jan;28(1):49-56.
30. Ultrastructural localization of extranuclear progestin receptors in the rat hippocampal formation. Waters EM, etal., J Comp Neurol. 2008 Nov 1;511(1):34-46. doi: 10.1002/cne.21826.
31. Progesterone receptors activation after acute cocaine administration. Wu HB, etal., Brain Res. 2006 Dec 18;1126(1):188-92. Epub 2006 Nov 15.
32. [The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis]. Zheng H, etal., Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 May;20(2):194-6.
33. Distribution and estrogen regulation of membrane progesterone receptor-beta in the female rat brain. Zuloaga DG, etal., Endocrinology. 2012 Sep;153(9):4432-43. doi: 10.1210/en.2012-1469. Epub 2012 Jul 9.
34. Disruption in the expression and immunolocalisation of steroid receptors and steroidogenic enzymes in letrozole-induced polycystic ovaries in rat. Zurvarra FM, etal., Reprod Fertil Dev. 2009;21(7):827-39.
Additional References at PubMed
PMID:1840636   PMID:8274433   PMID:10733525   PMID:11282275   PMID:11814428   PMID:11920725   PMID:12039952   PMID:12058073   PMID:12193379   PMID:12354672   PMID:12372000   PMID:12638125  
PMID:12771131   PMID:12897242   PMID:12952366   PMID:14671656   PMID:14681235   PMID:14763995   PMID:14764628   PMID:14765981   PMID:15189328   PMID:15219413   PMID:16176985   PMID:17277083  
PMID:17332059   PMID:17614295   PMID:17785366   PMID:17850461   PMID:17982270   PMID:18081559   PMID:18208546   PMID:18308846   PMID:18310454   PMID:18635654   PMID:18712784   PMID:18958180  
PMID:19506349   PMID:19818377   PMID:20375746   PMID:20535645   PMID:20555290   PMID:20660062   PMID:20702577   PMID:21119048   PMID:21695196   PMID:21981076   PMID:22326965   PMID:23153933  
PMID:23817898   PMID:23994211   PMID:24190884   PMID:24246438   PMID:24296318   PMID:24339918   PMID:24859236   PMID:24909783   PMID:25612677   PMID:30069875   PMID:31926947   PMID:34740365  


Genomics

Comparative Map Data
Pgr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8814,354,398 - 14,413,271 (+)NCBIGRCr8mRatBN7.286,072,673 - 6,131,552 (+)NCBImRatBN7.2mRatBN7.2mRatBN7.2 Ensembl86,072,673 - 6,131,344 (+)EnsemblmRatBN7.2 EnsemblUTH_Rnor_SHR_Utx810,003,167 - 10,062,099 (+)NCBIRnor_SHRUTH_Rnor_SHR_UtxUTH_Rnor_SHRSP_BbbUtx_1.088,300,792 - 8,359,726 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_WKY_Bbb_1.086,329,892 - 6,388,768 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0Rnor_6.087,128,656 - 7,187,796 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0Rnor_6.0 Ensembl87,128,656 - 7,187,796 (+)EnsemblRnor6.0rn6Rnor6.0Rnor_5.087,113,895 - 7,172,761 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0RGSC_v3.485,784,717 - 5,845,901 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4RGSC_v3.185,784,716 - 5,845,901 (+)NCBICelera87,609,728 - 7,668,047 (+)NCBICeleraCytogenetic Map8q11NCBI
PGR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811101,029,624 - 101,129,813 (-)NCBIGRCh38GRCh38hg38GRCh38GRCh38.p14 Ensembl11101,029,624 - 101,129,813 (-)EnsemblGRCh38hg38GRCh38GRCh3711100,900,355 - 101,000,544 (-)NCBIGRCh37GRCh37hg19GRCh37Build 3611100,414,313 - 100,506,465 (-)NCBINCBI36Build 36hg18NCBI36Build 3411100,414,312 - 100,506,465NCBICelera1198,069,715 - 98,169,894 (-)NCBICeleraCytogenetic Map11q22.1NCBIHuRef1196,837,449 - 96,937,628 (-)NCBIHuRefCHM1_111100,783,609 - 100,883,736 (-)NCBICHM1_1T2T-CHM13v2.011101,039,187 - 101,139,328 (-)NCBIT2T-CHM13v2.0
Pgr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3998,890,017 - 8,968,612 (+)NCBIGRCm39GRCm39mm39GRCm39 Ensembl98,899,834 - 8,968,612 (+)EnsemblGRCm39 EnsemblGRCm3898,898,900 - 8,968,611 (+)NCBIGRCm38GRCm38mm10GRCm38GRCm38.p6 Ensembl98,899,833 - 8,968,611 (+)EnsemblGRCm38mm10GRCm38MGSCv3798,899,833 - 8,968,611 (+)NCBIGRCm37MGSCv37mm9NCBIm37MGSCv3698,862,303 - 8,926,995 (+)NCBIMGSCv36mm8Celera96,279,529 - 6,348,253 (+)NCBICeleraCytogenetic Map9A1NCBIcM Map92.46NCBI
Pgr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554124,643,839 - 4,693,478 (-)NCBIChiLan1.0ChiLan1.0
PGR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29101,848,679 - 101,939,634 (-)NCBINHGRI_mPanPan1-v2NHGRI_mPanPan111102,925,904 - 103,028,120 (-)NCBINHGRI_mPanPan1Mhudiblu_PPA_v01195,997,677 - 96,098,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3PanPan1.11199,508,571 - 99,598,020 (-)NCBIpanpan1.1PanPan1.1panPan2
PGR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.121447,197 - 552,511 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1CanFam3.1 Ensembl21447,319 - 552,511 (+)EnsemblCanFam3.1canFam3CanFam3.1Dog10K_Boxer_Tasha21461,376 - 566,187 (+)NCBIDog10K_Boxer_TashaROS_Cfam_1.021609,104 - 717,242 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0 Ensembl21609,104 - 742,638 (+)EnsemblROS_Cfam_1.0 EnsemblUMICH_Zoey_3.121392,996 - 497,928 (+)NCBIUMICH_Zoey_3.1UNSW_CanFamBas_1.021478,480 - 583,792 (+)NCBIUNSW_CanFamBas_1.0UU_Cfam_GSD_1.021532,736 - 637,643 (+)NCBIUU_Cfam_GSD_1.0
Pgr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494784,948,508 - 85,038,416 (-)NCBIHiC_Itri_2SpeTri2.0 EnsemblNW_0049365516,498,553 - 6,573,222 (+)EnsemblSpeTri2.0SpeTri2.0 EnsemblSpeTri2.0NW_0049365516,498,553 - 6,573,212 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PGR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl932,035,684 - 32,129,221 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1Sscrofa11.1932,035,684 - 32,129,776 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1Sscrofa10.2936,044,789 - 36,138,540 (-)NCBISscrofa10.2Sscrofa10.2susScr3Pig Cytomap9p13-p11NCBI
PGR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1192,420,970 - 92,519,128 (-)NCBIChlSab1.1ChlSab1.1chlSab2ChlSab1.1 Ensembl192,430,453 - 92,517,296 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2Vero_WHO_p1.0NW_02366604333,353,079 - 33,447,583 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pgr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248781,714,559 - 1,762,421 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2HetGla 1.0NW_0046248781,714,196 - 1,769,302 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2
Variants

.
Variants in Pgr
277 total Variants
miRNA Target Status

Predicted Target Of
Summary ValueCount of predictions:135Count of miRNA genes:109Interacting mature miRNAs:125Transcripts:ENSRNOT00000038313Prediction methods:Miranda, TargetscanResult types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
Markers in Region
RH129476  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.286,118,296 - 6,118,502 (+)MAPPERmRatBN7.2Rnor_6.087,174,420 - 7,174,625NCBIRnor6.0Rnor_5.087,159,385 - 7,159,590UniSTSRnor5.0RGSC_v3.485,832,646 - 5,832,851UniSTSRGSC3.4Celera87,654,792 - 7,654,997UniSTSRH 3.4 Map80.0UniSTSCytogenetic Map8q11UniSTS
RH94493  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.286,131,303 - 6,131,491 (+)MAPPERmRatBN7.2Rnor_6.087,187,548 - 7,187,735NCBIRnor6.0Rnor_5.087,172,513 - 7,172,700UniSTSRnor5.0RGSC_v3.485,845,653 - 5,845,840UniSTSRGSC3.4Celera87,667,799 - 7,667,986UniSTSCytogenetic Map8q11UniSTS
RH142619  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.286,113,844 - 6,113,968 (+)MAPPERmRatBN7.2Rnor_6.087,169,968 - 7,170,091NCBIRnor6.0Rnor_5.087,154,933 - 7,155,056UniSTSRnor5.0RGSC_v3.485,828,194 - 5,828,317UniSTSRGSC3.4Celera87,650,340 - 7,650,463UniSTSCytogenetic Map8q11UniSTS


Related Rat Strains
The following Strains have been annotated to Pgr
SD-Pgrem1Soar    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 7
Low 14 8 56 34 23 9
Below cutoff 16 11 9 8 9 6 6 8 1 5 2 6
View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_022847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH004453 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM037358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM037359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM037360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM037361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HM037362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L16922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S68285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U06637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000038313   &xrArr;   ENSRNOP00000032053
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl86,072,673 - 6,131,344 (+)EnsemblRnor_6.0 Ensembl87,128,656 - 7,187,796 (+)Ensembl
RefSeq Acc Id: NM_022847   &xrArr;   NP_074038
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8814,354,398 - 14,413,271 (+)NCBImRatBN7.286,072,673 - 6,131,552 (+)NCBIRnor_6.087,128,656 - 7,187,796 (+)NCBIRnor_5.087,113,895 - 7,172,761 (+)NCBIRGSC_v3.485,784,717 - 5,845,901 (+)RGDCelera87,609,728 - 7,668,047 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_074038 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA19614 (Get FASTA)   NCBI Sequence Viewer  
  AAA19916 (Get FASTA)   NCBI Sequence Viewer  
  AAB29474 (Get FASTA)   NCBI Sequence Viewer  
  AAB29475 (Get FASTA)   NCBI Sequence Viewer  
  AAB29476 (Get FASTA)   NCBI Sequence Viewer  
  ADM52991 (Get FASTA)   NCBI Sequence Viewer  
  ADM52992 (Get FASTA)   NCBI Sequence Viewer  
  ADM52993 (Get FASTA)   NCBI Sequence Viewer  
  ADM52994 (Get FASTA)   NCBI Sequence Viewer  
  ADM52995 (Get FASTA)   NCBI Sequence Viewer  
  EDL78508 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000032053
  ENSRNOP00000032053.5
GenBank Protein Q63449 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_074038   &xlArr;   NM_022847
- UniProtKB: Q63449 (UniProtKB/Swiss-Prot),   F7FA48 (UniProtKB/TrEMBL),   E0YJE7 (UniProtKB/TrEMBL),   E0YJE6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000032053   &xlArr;   ENSRNOT00000038313
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63449-F1-model_v2 AlphaFold Q63449 1-923 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3317 AgrOrtholog
BioCyc Gene G2FUF-31749 BioCyc
Ensembl Genes ENSRNOG00000006831 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038313 ENTREZGENE
  ENSRNOT00000038313.5 UniProtKB/TrEMBL
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.50.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro NHR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Progest_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Znf_NHR/GATA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25154 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25154 ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROGESTERONE RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Hormone_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prog_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  zf-C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pgr PhenoGen
PRINTS PROGESTRONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STRDHORMONER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STROIDFINGER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE NR_LBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006831 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZnF_C4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48508 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E0YJE3_RAT UniProtKB/TrEMBL
  E0YJE6 ENTREZGENE, UniProtKB/TrEMBL
  E0YJE7 ENTREZGENE, UniProtKB/TrEMBL
  F7FA48 ENTREZGENE
  PRGR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F7FA48 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Pgr  Progesterone receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains promoter region +461 to +675 contains an estrogen responsive element-like region 625704
gene_drugs aromatase inhibitor 1,4,6-androstatriene-3,17-dione reduces PRir in fetal males 625704
gene_expression immunoreactivity higher in new born males than females in the anteroventral periventricular nucleus (AVPv) and medial preoptic nucleus(MPN) regions 625704
gene_function nuclear hormone receptor and transcription factor 625704
gene_process reduces glutamic acid decarboxylase-67 (GAD(67)) mRNA in the hypothalamus 729543
gene_process involved in the regulation of gene expression 625704
gene_process may contribute to the sex differences in brain affecting gene expression in nervous system 625704
gene_regulation prenatal exposure to either testosterone propionate or synthetic estrogen increases progesterone receptor expression (PRir) in fetal females; aromatization of testosterone to estrogen important for sex difference in PR expression 625704
gene_transcript multiple mRNA transcripts are transcribed from the gene with two isoforms found expressed in rat 625704
gene_transcript gene contains two distinct promoter regions from -131 to +65 and from +461 to +675 625704
 


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