Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

The importance of folate in reproduction can be appreciated by considering that the
existence of the vitamin was first suspected from efforts to explain a potentially fatal …

Homocysteine is a sulfur-containing amino acid derived from the metabolism of methionine,
an essential amino acid, and is metabolized by one of two pathways: remethylation or …

BACKGROUND Little is known about the effect of paternal nutrition on aneuploidy in sperm.
We investigated the association of normal dietary and supplement intake of folate, zinc and …

Almost 15 years ago it was hypothesized that polymorphisms of genes encoding enzymes
involved in folate metabolism could lead to aberrant methylation of peri-centromeric regions …

Background Several studies around the world support the hypothesis that genetic
polymorphisms involved in folate metabolism could be related to the maternal risk for Down …

PURPOSE: We present a case-control study of seven polymorphisms of six genes involved
in homocysteine/folate pathway as risk factors for Down syndrome. Gene-gene/allele-allele …

Point mutations in methylenetetrahydrofolate reductase (MTHFR) and
hyperhomocysteinemia were implicated in the pathogenesis of diabetic nephropathy (DN) in …

Background: The gene for 5, 10-methylenetetrahydrofolate reductase (NAD (P) H) or
MTHFR gene encodes protein methylenetetrahydrofolate reductase (MTHFR), an enzyme …

Folates are essential nutrients that are required for one-carbon biosynthetic and epigenetic
processes. A deficiency in cellular folates results in aberrant DNA methylation, point …