The potential use of mesenchymal stem cells and their exosomes in Parkinson's disease treatment

RM Heris, M Shirvaliloo, S Abbaspour-Aghdam… - Stem Cell Research & …, 2022 - Springer
Parkinson's disease (PD) is the second most predominant neurodegenerative disease
worldwide. It is recognized clinically by severe complications in motor function caused by …

Cell-therapy for Parkinson's disease: A systematic review and meta-analysis

F Wang, Z Sun, D Peng, S Gianchandani, W Le… - Journal of Translational …, 2023 - Springer
Background Cell-based strategies focusing on replacement or protection of dopaminergic
neurons have been considered as a potential approach to treat Parkinson's disease (PD) for …

Stem cell therapies for chronic liver diseases: progress and challenges

TT Li, ZR Wang, WQ Yao, EQ Linghu… - Stem Cells …, 2022 - academic.oup.com
Chronic liver diseases have become a significant health issue worldwide and urgently
require the development of novel therapeutic approaches, in addition to liver transplantation …

Cell-based therapies for neurological disorders—the bioreactor hypothesis

SI Savitz, CS Cox Jr - Nature Reviews Neurology, 2023 - nature.com
Cell-based therapies are an emerging biopharmaceutical paradigm under investigation for
the treatment of a range of neurological disorders. Accumulating evidence is demonstrating …

miR-100a-5p-enriched exosomes derived from mesenchymal stem cells enhance the anti-oxidant effect in a Parkinson's disease model via regulation of Nox4/ROS …

S He, Q Wang, L Chen, YJ He, X Wang… - Journal of Translational …, 2023 - Springer
Abstract Background The pathogenesis of Parkinson's disease (PD) has not been fully
elucidated, and there are no effective disease-modifying drugs for the treatment of PD …

Does ethnicity influence recruitment into clinical trials of Parkinson's disease?

YH Lau, A Podlewska, J Ocloo, A Gupta… - Journal of …, 2022 - content.iospress.com
Background: Lack of participation of black and minority ethnic communities (BAME) in
registered clinical trials is a concern as data emerging from these studies are used to licence …

Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson's disease in animal models

J Li, N Li, J Wei, C Feng, Y Chen, T Chen, Z Ai… - npj Parkinson's …, 2022 - nature.com
Although striatal delivery of three critical genes for dopamine synthesis by viruses is a
potential clinical approach for treating Parkinson's disease (PD), the approach makes it …

Secretomes as an emerging class of bioactive ingredients for enhanced cosmeceutical applications

KX Tan, T Chang, X Lin - Experimental Dermatology, 2022 - Wiley Online Library
Skin ageing is predominantly caused by either intrinsic or extrinsic factors, leading to
undesirable skin features. Advancements in both molecular and cellular fields have created …

[HTML][HTML] Applying stem cell therapy in intractable diseases: a narrative review of decades of progress and challenges

APK Ling, YP Wong - Stem Cell Investigation, 2022 - ncbi.nlm.nih.gov
Applying stem cell therapy in intractable diseases: a narrative review of decades of progress
and challenges - PMC Back to Top Skip to main content NIH NLM Logo Access keys NCBI …

Clinical trials for cognition in Parkinson's disease: Where are we and how can we do better?

E Bayram, L Batzu, B Tilley, R Gandhi, P Jagota… - Parkinsonism & Related …, 2023 - Elsevier
Background Cognitive impairment is common in Parkinson's disease (PD) and has a
substantial impact on quality of life. Despite numerous trials targeting various PD features …