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| Status |
Public on Aug 04, 2022 |
| Title |
Molecular and behavioral consequences of Ube3a gene overdosage in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Here, we investigated the neurodevelopmental impact of Ube3a gene overdosage using bacterial artificial chromosome-based transgenic mouse models (Ube3aOE) that recapitulate the increases in Ube3a copy number most often observed in Dup15q.Here, we investigated the neurodevelopmental impact of Ube3a gene overdosage using bacterial artificial chromosome-based transgenic mouse models (Ube3aOE) that recapitulate the increases in Ube3a copy number most often observed in Dup15q.
Hereto we performed gene expression profiling analysis using data obtained from RNA-seq of cortical and hippocampal tissue from wildtype and Ube3aOE mice
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for cortical and hippocampal brain tissue of 5 wildtype and 5 Ube3aOE mice
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| Contributor(s) |
Punt AM, Judson MC, Sidorov MS, Johnson NS, Belder S, den Hertog D, Davis CR, Feygin MS, Jolfaei MA, van Ijcken WF, Elgersma Y, Philpot BD |
| Citation(s) |
36134658 |
| |
| Submission date |
May 31, 2022 |
| Last update date |
Nov 03, 2022 |
| Contact name |
Mattijs Punt |
| E-mail(s) |
a.m.punt@erasmusmc.nl
|
| Phone |
0648216382
|
| Organization name |
Erasmus MC
|
| Department |
Clinical Genetics
|
| Street address |
Dr. Molewaterplein 40
|
| City |
Rotterdam |
| State/province |
Zuid-Holland |
| ZIP/Postal code |
3015 GD |
| Country |
Netherlands |
| |
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| Platforms (1) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
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| Samples (20)
|
| GSM6205528 |
Wildtype cortex P7 mouse #4 [Sample 4] |
| GSM6205529 |
Wildtype cortex P7 mouse #5 [Sample 5] |
| GSM6205530 |
Ube3aOE cortex P7 mouse #6 [Sample 6] |
| GSM6205531 |
Ube3aOE cortex P7 mouse #7 [Sample 7] |
| GSM6205532 |
Ube3aOE cortex P7 mouse #8 [Sample 8] |
| GSM6205533 |
Ube3aOE cortex P7 mouse #9 [Sample 9] |
| GSM6205534 |
Ube3aOE cortex P7 mouse#10 [Sample 10] |
| GSM6205535 |
Wildtype hippocampus P7 mouse #1 [Sample 11] |
| GSM6205536 |
Wildtype hippocampus P7 mouse #2 [Sample 12] |
| GSM6205537 |
Wildtype hippocampus P7 mouse #3 [Sample 13] |
| GSM6205538 |
Wildtype hippocampus P7 mouse #4 [Sample 14] |
| GSM6205539 |
Wildtype hippocampus P7 mouse #5 [Sample 15] |
| GSM6205540 |
Ube3aOE hippocampus P7 mouse #6 [Sample 16] |
| GSM6205541 |
Ube3aOE hippocampus P7 mouse #7 [Sample 17] |
| GSM6205542 |
Ube3aOE hippocampus P7 mouse #8 [Sample 18] |
| GSM6205543 |
Ube3aOE hippocampus P7 mouse #9 [Sample 19] |
| GSM6205544 |
Ube3aOE hippocampus P7 mouse #10 [Sample 20] |
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| Relations |
| BioProject |
PRJNA843957 |
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