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. 2020 Apr 30;382(18):1708-1720.
doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.

Clinical Characteristics of Coronavirus Disease 2019 in China

Wei-Jie Guan  1 , Zheng-Yi Ni  1 , Yu Hu  1 , Wen-Hua Liang  1 , Chun-Quan Ou  1 , Jian-Xing He  1 , Lei Liu  1 , Hong Shan  1 , Chun-Liang Lei  1 , David S C Hui  1 , Bin Du  1 , Lan-Juan Li  1 , Guang Zeng  1 , Kwok-Yung Yuen  1 , Ru-Chong Chen  1 , Chun-Li Tang  1 , Tao Wang  1 , Ping-Yan Chen  1 , Jie Xiang  1 , Shi-Yue Li  1 , Jin-Lin Wang  1 , Zi-Jing Liang  1 , Yi-Xiang Peng  1 , Li Wei  1 , Yong Liu  1 , Ya-Hua Hu  1 , Peng Peng  1 , Jian-Ming Wang  1 , Ji-Yang Liu  1 , Zhong Chen  1 , Gang Li  1 , Zhi-Jian Zheng  1 , Shao-Qin Qiu  1 , Jie Luo  1 , Chang-Jiang Ye  1 , Shao-Yong Zhu  1 , Nan-Shan Zhong  1 ; China Medical Treatment Expert Group for Covid-19
Collaborators, Affiliations

Clinical Characteristics of Coronavirus Disease 2019 in China

Wei-Jie Guan et al. N Engl J Med. .

Abstract

Background: Since December 2019, when coronavirus disease 2019 (Covid-19) emerged in Wuhan city and rapidly spread throughout China, data have been needed on the clinical characteristics of the affected patients.

Methods: We extracted data regarding 1099 patients with laboratory-confirmed Covid-19 from 552 hospitals in 30 provinces, autonomous regions, and municipalities in mainland China through January 29, 2020. The primary composite end point was admission to an intensive care unit (ICU), the use of mechanical ventilation, or death.

Results: The median age of the patients was 47 years; 41.9% of the patients were female. The primary composite end point occurred in 67 patients (6.1%), including 5.0% who were admitted to the ICU, 2.3% who underwent invasive mechanical ventilation, and 1.4% who died. Only 1.9% of the patients had a history of direct contact with wildlife. Among nonresidents of Wuhan, 72.3% had contact with residents of Wuhan, including 31.3% who had visited the city. The most common symptoms were fever (43.8% on admission and 88.7% during hospitalization) and cough (67.8%). Diarrhea was uncommon (3.8%). The median incubation period was 4 days (interquartile range, 2 to 7). On admission, ground-glass opacity was the most common radiologic finding on chest computed tomography (CT) (56.4%). No radiographic or CT abnormality was found in 157 of 877 patients (17.9%) with nonsevere disease and in 5 of 173 patients (2.9%) with severe disease. Lymphocytopenia was present in 83.2% of the patients on admission.

Conclusions: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness. Patients often presented without fever, and many did not have abnormal radiologic findings. (Funded by the National Health Commission of China and others.).

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Figure 1
Figure 1. Distribution of Patients with Covid-19 across Mainland China.
Shown are the official statistics of all documented, laboratory-confirmed cases of coronavirus disease 2019 (Covid-19) throughout China, according to the National Health Commission as of February 4, 2020. The numerator denotes the number of patients who were included in the study cohort and the denominator denotes the number of laboratory-confirmed cases for each province, autonomous region, or provincial municipality, as reported by the National Health Commission.
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