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Planta Med 1988; 54(2): 111-113
DOI: 10.1055/s-2006-962363
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© Georg Thieme Verlag Stuttgart · New York

Hypotensive Activity of Extracts of Solanum marginatum in the Rat

Horacio Vidrio1 , Bertha Soto2 , Federico García3 , Sylvia Méndez2
  • 1Department of Pharmacology, School of Medicine, National University of Mexico, Apartado Postal 70-297, 04510 Mexico, D.F., Mexico.
  • 2Department of Pharmaceutical Chemistry and Natural Products, School of Chemistry, National University of Mexico, Ciudad Universitaria, 04510 Mexico, D.F., Mexico.
  • 3Institute of Chemistry, National University of Mexico, Ciudad Universitaria, 04510 Mexico, D.F., Mexico.
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Publication History

1987

Publication Date:
24 January 2007 (online)

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Abstract

In view of the structural resemblance between glycoalkaloids found in plants of the genus Solanum and the veratrum alkaloids, the possible hypotensive activity of crude extracts of S. marginatum was determined in anesthetized rats. The whole plant methanolic extract produced immediate marked hypotension and bradycardia which persisted for 60 min. An aqueous extract of the above, as well as a methanolic fruit extract produced only transient effects. Oral administration of the active material to conscious renal hypertensive rats produced a significant fall in blood pressure lasting between 4 and 6 h. The hypotensive activity observed was tentatively attributed to compounds of intermediate polarity, possibly glycoalkaloids or non-alkaloidal glycosides. No information as to the possible “veratrum-like” nature of these effects could be derived from the present experiments.

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