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Planta Med 1988; 54(6): 511-513
DOI: 10.1055/s-2006-962532
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© Georg Thieme Verlag Stuttgart · New York

Ellagic Acid Derivatives of Agrostistachys hookeri 1

Young-Hee Choi, John M. Pezzuto, A. Douglas Kinghorn, Norman R. Farnsworth
  • Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, U.S.A.
1 Plant Anticancer Agents. XLVII. For the previous paper in this series, see Ref. (1).
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Publication History

1988

Publication Date:
24 January 2007 (online)

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Abstract

Further bioactivity-guided fractionation of a chloroform extract of the twigs of Agrostistachys hookeri against cultured P-388 lymphocytic leukemia cells, has led to the isolation of a cytotoxic ellagic acid derivative, 3,3′,4-O-trimethylellagic acid (1), and three inactive compounds, consisting of a new compound, 3,4,5,5′-O-tetramethyl-3′,4′-O,O-methylidenecoruleoellagic acid (2), and the known compounds, 3,4,5-O-trimethyl-3′,4′-O,O-methylideneflavellagic acid (3) and betulinic acid. The structure of the novel coruleoellagic acid derivative (2) was established by comparison of its spectral parameters with those of known ellagic acid derivatives.

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