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Synthesis 2022(10): 1610-1614
DOI: 10.1055/s-2003-40531
DOI: 10.1055/s-2003-40531
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York
Microwave-Assisted One-Pot Synthesis of 2,4-Disubstituted Quinolines under Solvent-Free Conditions
Weitere Informationen
Received
24 April 2003
Publikationsdatum:
08. Juli 2003 (online)
Publikationsverlauf
Publikationsdatum:
08. Juli 2003 (online)
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Abstract
Aromatic imines derived in situ from aryl aldehydes and aryl amines undergo smoothly, cyclization with alkynes on the surface of montmorillonite clay impregnated with copper(I) bromide under solvent-free conditions to produce 2,4-disubstituted quinolines in high yields with excellent selectivity. The reaction rates and yields are significantly improved by employing microwave irradiation.
Key words
microwave - aryl imines - alkynes - substituted quinolines
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