Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications
- PMID: 21570444
- DOI: 10.1016/j.fct.2011.04.032
Profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications
Abstract
Phytotherapy has played an important role in the management of diabetes and related complications. In the present study different fractions of Catharanthus roseus L. (Apocynaceae), Ocimum sanctum L. (Labiatae), Tinospora cordifolia Willd. (Menispermaceae), Aegle marmelos L. (Rutaceae), Ficus golmerata L. (Moraceae), Psoralea corlifolia L. (Fabaceae), Tribulus terrestris L. (Zygophyllaceae), and Morinda cetrifolia L. (Rubiaceae) were evaluated as possible inhibitors of aldose reductase (AR: a key enzyme implicated in cataractogenesis) and antioxidant agents. Anti-cataract activity of the selected plants was demonstrated using 'sugar induced lens opacity model' and the cytotoxicity studies were carried out using MTT assay. Among the tested plants, water extract of M. cetrifolia (IC50 0.132 mg/ml) exhibited maximum AR inhibitory activity as compared to other phytofractions which showed the activity in an IC50 range of 0.176-0.0.82 mg/ml. All the plant fractions showed considerable antioxidant potential. Sugar induced lens opacity studies revealed that, M. cetrifolia possess significant anti-cataract potential to maintain lens opacity as compared to glucose induced lens opacity in bovine lens model. The extract of the selected plants showed moderate cytotoxicity against HeLa cell line. Results of the present studies may find useful in converting botanicals into therapeutic modalities.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Similar articles
-
Inhibition of aldose reductase by Aegle marmelos and its protective role in diabetic cataract.J Ethnopharmacol. 2013 Aug 26;149(1):215-21. doi: 10.1016/j.jep.2013.06.025. Epub 2013 Jul 1. J Ethnopharmacol. 2013. PMID: 23827758
-
Effect of Diabecon on sugar-induced lens opacity in organ culture: mechanism of action.J Ethnopharmacol. 2005 Feb 28;97(2):397-403. doi: 10.1016/j.jep.2004.11.032. Epub 2005 Jan 18. J Ethnopharmacol. 2005. PMID: 15707781
-
Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract.Mol Vis. 2004 Mar 12;10:148-54. Mol Vis. 2004. PMID: 15031705
-
Natural therapies for ocular disorders, part two: cataracts and glaucoma.Altern Med Rev. 2001 Apr;6(2):141-66. Altern Med Rev. 2001. PMID: 11302779 Review.
-
Aldose reductase inhibitors.Pharmacotherapy. 1990;10(5):326-36. Pharmacotherapy. 1990. PMID: 2122421 Review.
Cited by
-
Medicinal plants used for management of diabetes and hypertension in Ghana.Heliyon. 2023 Nov 29;9(12):e22977. doi: 10.1016/j.heliyon.2023.e22977. eCollection 2023 Dec. Heliyon. 2023. PMID: 38076168 Free PMC article.
-
Using Guduchi (Tinospora cordifolia) as an eco-friendly feed supplement in human and poultry nutrition.Poult Sci. 2020 Feb;99(2):801-811. doi: 10.1016/j.psj.2019.10.051. Epub 2019 Nov 29. Poult Sci. 2020. PMID: 32029162 Free PMC article. Review.
-
Molecular docking analysis of candidate compoundsderived from medicinal plants with type 2 diabetes mellitus targets.Bioinformation. 2019 Mar 15;15(3):179-188. doi: 10.6026/97320630015179. eCollection 2019. Bioinformation. 2019. PMID: 31354193 Free PMC article.
-
Medicinal Plants and Natural Products Used in Cataract Management.Front Pharmacol. 2019 Jun 13;10:466. doi: 10.3389/fphar.2019.00466. eCollection 2019. Front Pharmacol. 2019. PMID: 31263410 Free PMC article. Review.
-
Dietary flavonoids inhibit the glycation of lens proteins: implications in the management of diabetic cataract.3 Biotech. 2019 Feb;9(2):47. doi: 10.1007/s13205-019-1581-3. Epub 2019 Jan 23. 3 Biotech. 2019. PMID: 30729071 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials