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Randomized Controlled Trial
. 2018 Mar;18(1):120-131.
doi: 10.4314/ahs.v18i1.16.

Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly

Shehab M Abd El-Kader  1 , Fadwa M Al-Shreef  2
Affiliations
Randomized Controlled Trial

Inflammatory cytokines and immune system modulation by aerobic versus resisted exercise training for elderly

Shehab M Abd El-Kader et al. Afr Health Sci. 2018 Mar.

Abstract

Background: Aging is characterized with immunosenescence associated with a hyper-inflammatory state, characterized by elevated circulating levels of pro-inflammatory mediators. Physical exercise is a potential strategy for improving the immune system dysfunction and chronic inflammation that accompanies aging. However, there is a need to differentiate between aerobic and resistance exercise training regarding human immune system and systemic inflammation among the elderly Saudi population.

Objective: The aim of this study was to compare the impact of 6 months of aerobic versus resisted exercise training on inflammatory cytokines and immune system response among elderly.

Material and methods: Sixty previously sedentary elderly subjects participated in this study, their age ranged from 61-66 years. All Subjects were randomly assigned to supervised aerobic exercise intervention group (group A, n=40) or resistance exercise group (group B, n=40). Number of CD3+,CD4+,CD8+ T cells count and CD4/CD8 ratio were quantified, IL-6, TNF-α and IL10 were measured before and after 6 months, at the end of the study.

Results: The mean values of CD3+, CD4+ and CD8+ T cells count and IL-10 were significantly increased, whereas the mean values of CD4/CD8 ratio, IL-6 and TNF-α were significantly decreased in group (A) and group (B). Also; there were significant differences between mean levels of the investigated parameters in group (A) and group (B) after treatment.

Conclusion: The current study provides evidence that aerobic exercise is more appropriate in modulating the immune system and inflammatory markers among the elderly population.

Keywords: Immune function; aerobic exercise; aging; inflammatory cytokines; resistance exercise.

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Figure (1)
Subjects screening and recruitment CONSORT diagram.
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