Physiological insulinemia acutely modulates plasma leptin
- PMID: 9568685
- DOI: 10.2337/diabetes.47.4.544
Physiological insulinemia acutely modulates plasma leptin
Abstract
Whether insulin acutely regulates plasma leptin in humans is controversial. We examined the dosage-response and time-course characteristics of the effect of insulin on leptin in 10 men (age 42+/-2 years [mean+/-SE]; BMI 29.3+/-2.0 kg/m2). Each individual underwent four 9-h euglycemic clamps (insulin at 20, 40, 80, and 400 mU x m[-2] x min[-1) and a control saline infusion. Although plasma glucose and insulin levels remained constant, leptin diminished from 9.1+/-3.0 to 5.9+/-2.1 ng/ml (P < 0.001) by the end of the control experiment. Conversely, plasma leptin showed a dosage-dependent increase during the insulin infusions that was evident within 30-60 min. The insulin-induced increase in leptin was proportionately lower in obese insulin-resistant men. Free fatty acids (FFAs) decreased during insulin and did not change during saline infusions. ED50 (the dose producing half-maximal effect) for insulin's effect on leptin and FFA was similar (138+/-36 vs. 102+/-24 pmol/l, respectively; P=0.11). To further define the role of physiological insulinemia, we compared the effect of a very low dosage insulin infusion (10 mU x m[-2] x min[-1]) with that of a control saline infusion in another group of 10 men (mean age 39+/-3 years; BMI 27.1+/-1.0 kg/m2). Plasma leptin remained stable during that insulin infusion, but fell by 37+/-2% in the control experiment. Thus physiological insulinemia can acutely regulate plasma leptin. Insulin could mediate the effect of caloric intake on leptin and could be a determinant of its plasma concentration. Inadequate insulin-induced leptin production in obese and insulin-resistant subjects may contribute to the development or worsening of obesity.
Similar articles
-
Effect of obesity on susceptibility to fatty acid-induced peripheral tissue insulin resistance.Metabolism. 2003 Feb;52(2):233-8. doi: 10.1053/meta.2003.50029. Metabolism. 2003. PMID: 12601639
-
Sex differences in African-Americans regarding sensitivity to insulin's glucoregulatory and antilipolytic actions.Diabetes Care. 1999 Jan;22(1):71-7. doi: 10.2337/diacare.22.1.71. Diabetes Care. 1999. PMID: 10333906
-
Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats.Am J Physiol. 1998 Jun;274(6):E998-E1001. doi: 10.1152/ajpendo.1998.274.6.E998. Am J Physiol. 1998. PMID: 9611148
-
Relationships of plasma leptin levels to changes in plasma free fatty acids in women who are lean and women who are abdominally obese.Obes Res. 1997 Sep;5(5):442-6. doi: 10.1002/j.1550-8528.1997.tb00668.x. Obes Res. 1997. PMID: 9385619
-
Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects.Diabetes. 1996 Oct;45(10):1364-6. doi: 10.2337/diab.45.10.1364. Diabetes. 1996. PMID: 8826972
Cited by
-
The Role of Cdc42 in the Insulin and Leptin Pathways Contributing to the Development of Age-Related Obesity.Nutrients. 2023 Nov 29;15(23):4964. doi: 10.3390/nu15234964. Nutrients. 2023. PMID: 38068822 Free PMC article. Review.
-
Association of Leptin with Glucose Intolerance and Gestational Diabetes Mellitus in Pregnant Women: Prospective Analytical Case-Control Study.Reprod Sci. 2024 Mar;31(3):773-778. doi: 10.1007/s43032-023-01354-1. Epub 2023 Oct 10. Reprod Sci. 2024. PMID: 37816990
-
Maternal obesity and the impact of associated early-life inflammation on long-term health of offspring.Front Cell Infect Microbiol. 2022 Sep 16;12:940937. doi: 10.3389/fcimb.2022.940937. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 36189369 Free PMC article. Review.
-
Function of Uric Acid Transporters and Their Inhibitors in Hyperuricaemia.Front Pharmacol. 2021 Jul 14;12:667753. doi: 10.3389/fphar.2021.667753. eCollection 2021. Front Pharmacol. 2021. PMID: 34335246 Free PMC article.
-
Leptin and Obesity: Role and Clinical Implication.Front Endocrinol (Lausanne). 2021 May 18;12:585887. doi: 10.3389/fendo.2021.585887. eCollection 2021. Front Endocrinol (Lausanne). 2021. PMID: 34084149 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Research Materials