Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects
- PMID: 16652130
- DOI: 10.1038/sj.ijo.0803351
Body fat loss achieved by stimulation of thermogenesis by a combination of bioactive food ingredients: a placebo-controlled, double-blind 8-week intervention in obese subjects
Abstract
Background: A combination of tyrosine, capsaicin, catechines and caffeine may stimulate the sympathetic nervous system and promote satiety, lipolysis and thermogenesis. In addition, dietary calcium may increase fecal fat excretion.
Objective: To investigate the acute and subchronic effect of a supplement containing the above mentioned agents or placebo taken t.i.d on thermogenesis, body fat loss and fecal fat excretion.
Design: In total, 80 overweight-obese subjects ((body mass index) 31.2+/-2.5 kg/m(2), mean+/-s.d.) underwent an initial 4-week hypocaloric diet (3.4 MJ/day). Those who lost>4% body weight were instructed to consume a hypocaloric diet (-1.3 MJ/day) and were randomized to receive either placebo (n=23) or bioactive supplement (n=57) in a double-blind, 8-week intervention. The thermogenic effect of the compound was tested at the first and last day of intervention, and blood pressure, heart rate, body weight and composition were assessed.
Results: Weight loss during the induction phase was 6.8+/-1.9 kg. At the first exposure the thermogenic effect of the bioactive supplement exceeded that of placebo by 87.3 kJ/4 h (95%CI: 50.9;123.7, P=0.005) and after 8 weeks this effect was sustained (85.5 kJ/4 h (47.6;123.4), P=0.03). Body fat mass decreased more in the supplement group by 0.9 kg (0.5; 1.3) compared with placebo (P<0.05). The bioactive supplement had no effect on fecal fat excretion, blood pressure or heart rate.
Conclusion: The bioactive supplement increased 4-h thermogenesis by 90 kJ more than placebo, and the effect was maintained after 8 weeks and accompanied by a slight reduction in fat mass. These bioactive components may support weight maintenance after a hypocaloric diet.
Similar articles
-
Thermogenic ingredients and body weight regulation.Int J Obes (Lond). 2010 Apr;34(4):659-69. doi: 10.1038/ijo.2009.299. Epub 2010 Feb 9. Int J Obes (Lond). 2010. PMID: 20142827 Review.
-
The effect of caffeine, green tea and tyrosine on thermogenesis and energy intake.Eur J Clin Nutr. 2009 Jan;63(1):57-64. doi: 10.1038/sj.ejcn.1602901. Epub 2007 Sep 19. Eur J Clin Nutr. 2009. PMID: 17882140 Clinical Trial.
-
Long-term effects of consumption of a novel fat emulsion in relation to body-weight management.Int J Obes (Lond). 2007 Jun;31(6):942-9. doi: 10.1038/sj.ijo.0803532. Epub 2007 Feb 13. Int J Obes (Lond). 2007. PMID: 17299383 Clinical Trial.
-
Bioactive food stimulants of sympathetic activity: effect on 24-h energy expenditure and fat oxidation.Eur J Clin Nutr. 2005 Jun;59(6):733-41. doi: 10.1038/sj.ejcn.1602121. Eur J Clin Nutr. 2005. PMID: 15870822 Clinical Trial.
-
Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview.J Med. 2002;33(1-4):247-64. J Med. 2002. PMID: 12939122 Review.
Cited by
-
Chronic Thermogenic Dietary Supplement Consumption: Effects on Body Composition, Anthropometrics, and Metabolism.Nutrients. 2023 Nov 17;15(22):4806. doi: 10.3390/nu15224806. Nutrients. 2023. PMID: 38004200 Free PMC article. Clinical Trial.
-
Efficacy of Triphala extracts on the changes of obese fecal microbiome and metabolome in the human gut model.J Tradit Complement Med. 2023 Feb 28;13(2):207-217. doi: 10.1016/j.jtcme.2023.02.011. eCollection 2023 Mar. J Tradit Complement Med. 2023. PMID: 36970454 Free PMC article.
-
Interventions associated with brown adipose tissue activation and the impact on energy expenditure and weight loss: A systematic review.Front Endocrinol (Lausanne). 2022 Dec 9;13:1037458. doi: 10.3389/fendo.2022.1037458. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36568070 Free PMC article.
-
Association of dietary phytochemical index with metabolically unhealthy overweight/obesity phenotype among Iranian women: A cross-sectional study.Front Nutr. 2022 Oct 25;9:959341. doi: 10.3389/fnut.2022.959341. eCollection 2022. Front Nutr. 2022. PMID: 36386941 Free PMC article.
-
Capsaicin for Weight Control: "Exercise in a Pill" (or Just Another Fad)?Pharmaceuticals (Basel). 2022 Jul 11;15(7):851. doi: 10.3390/ph15070851. Pharmaceuticals (Basel). 2022. PMID: 35890150 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical