Molecular targets for the cancer preventive activity of tea polyphenols
- PMID: 16652355
- DOI: 10.1002/mc.20228
Molecular targets for the cancer preventive activity of tea polyphenols
Abstract
Inhibition of carcinogenesis by tea and tea polyphenols has been demonstrated in many animal models. The mechanisms of action have been extensively investigated mostly in cell culture systems with (-)-epigallocatechin-3-gallate (EGCG), the most active and major polyphenolic compound from green tea. However, the mechanisms of cancer preventive activity by tea and tea polyphenols are not clearly understood. This article discusses some of the reported mechanisms and possible targets for the action of EGCG. The difficulties and major issues in extrapolating data from studies in cancer cell lines to cancer prevention mechanisms are discussed. Activities observed in cell culture with high concentrations of EGCG may not be relevant because of the limited systemic bioavailability of EGCG. In addition, possible artifacts due to the auto-oxidation of EGCG may complicate this issue. Some recent studies revealed high-affinity EGCG binding proteins as possible direct targets for the action of EGCG. Validating the related cancer preventive mechanisms found in in vitro studies in animal models and human samples would be exciting.
Similar articles
-
Methylation suppresses the proteasome-inhibitory function of green tea polyphenols.J Cell Physiol. 2007 Oct;213(1):252-60. doi: 10.1002/jcp.21124. J Cell Physiol. 2007. PMID: 17477351
-
Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo.Clin Cancer Res. 2007 Mar 1;13(5):1611-9. doi: 10.1158/1078-0432.CCR-06-2269. Clin Cancer Res. 2007. PMID: 17332308
-
Green tea polyphenols and its constituent epigallocatechin gallate inhibits proliferation of human breast cancer cells in vitro and in vivo.Cancer Lett. 2007 Jan 8;245(1-2):232-41. doi: 10.1016/j.canlet.2006.01.027. Epub 2006 Mar 6. Cancer Lett. 2007. PMID: 16519995
-
Possible mechanisms of the cancer-preventive activities of green tea.Mol Nutr Food Res. 2006 Feb;50(2):170-5. doi: 10.1002/mnfr.200500105. Mol Nutr Food Res. 2006. PMID: 16425280 Review.
-
Potential molecular targets of tea polyphenols in human tumor cells: significance in cancer prevention.In Vivo. 2002 Nov-Dec;16(6):397-403. In Vivo. 2002. PMID: 12494882 Review.
Cited by
-
Role for Plant-Derived Antioxidants in Attenuating Cancer Cachexia.Antioxidants (Basel). 2022 Jan 18;11(2):183. doi: 10.3390/antiox11020183. Antioxidants (Basel). 2022. PMID: 35204066 Free PMC article. Review.
-
A combination of Citrus reticulata peel and black tea inhibits migration and invasion of liver cancer via PI3K/AKT and MMPs signaling pathway.Mol Biol Rep. 2020 Jan;47(1):507-519. doi: 10.1007/s11033-019-05157-z. Epub 2019 Oct 30. Mol Biol Rep. 2020. PMID: 31673889
-
Tea and Its Components Prevent Cancer: A Review of the Redox-Related Mechanism.Int J Mol Sci. 2019 Oct 23;20(21):5249. doi: 10.3390/ijms20215249. Int J Mol Sci. 2019. PMID: 31652732 Free PMC article. Review.
-
Alternative Oral Agents in Prophylaxis and Therapy of Uterine Fibroids-An Up-to-Date Review.Int J Mol Sci. 2017 Dec 1;18(12):2586. doi: 10.3390/ijms18122586. Int J Mol Sci. 2017. PMID: 29194370 Free PMC article. Review.
-
Comparative effects of green and black tea extracts on lowering serum uric acid in hyperuricemic mice.Pharm Biol. 2017 Dec;55(1):2123-2128. doi: 10.1080/13880209.2017.1377736. Pharm Biol. 2017. PMID: 28938867 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
