Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats
- PMID: 18524448
- DOI: 10.1016/j.fct.2008.04.022
Hepatoprotective potentials of Phyllanthusamarus against ethanol-induced oxidative stress in rats
Abstract
The hepatoprotective effect of methanolic extract of the leaf of Phyllanthus amarus (P. amarus) against ethanol-induced oxidative damage was investigated in adult male Wistar albino rats. P. amarus (250 and 500 mg/kg/day) and ethanol (5 g/kg/day, 20% w/v) were administered orally to animals for 4 weeks and 3 weeks, respectively. Ethanol treatment markedly decreased the level of reduced glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in the liver, which were significantly enhanced by P. amarus treatment. Glutathione-S transferase (GST), which was increased after chronic ethanol administration, was significantly reduced by P. amarus treatment in the liver. Also, P. amarus significantly increased the activities of hepatic alanine transaminase (ALT) and aspartate transaminase (AST) as well as alkaline phosphatase (ALP), with a concomitant marked reduction in the plasma activity of the transaminases in the ethanol-challenged rats. Lipid peroxidation level, which was increased after chronic ethanol administration, was significantly reduced in the liver by P. amarus co-treatment. Results show that P. amarus leaf extract could protect the liver against ethanol-induced oxidative damage by possibly reducing the rate of lipid peroxidation and increasing the antioxidant defence mechanism in rats.
Similar articles
-
Autophagy in alcoholic liver disease, self-eating triggered by drinking.Clin Res Hepatol Gastroenterol. 2015 Sep;39 Suppl 1(Suppl 1):S2-6. doi: 10.1016/j.clinre.2015.05.023. Epub 2015 Jul 15. Clin Res Hepatol Gastroenterol. 2015. PMID: 26186877 Free PMC article. Review.
-
Protective effects of aqueous extract of Hammada scoparia against hepatotoxicity induced by ethanol in the rat.Toxicol Ind Health. 2014 Mar;30(2):113-22. doi: 10.1177/0748233712452602. Epub 2012 Jul 9. Toxicol Ind Health. 2014. PMID: 22778112
-
Cnidoscolus aconitifolius leaf extract protects against hepatic damage induced by chronic ethanol administration in Wistar rats.Alcohol Alcohol. 2011 Jul-Aug;46(4):451-8. doi: 10.1093/alcalc/agr060. Epub 2011 May 26. Alcohol Alcohol. 2011. PMID: 21616948
-
Diallyl trisulfide (DATS) effectively attenuated oxidative stress-mediated liver injury and hepatic mitochondrial dysfunction in acute ethanol-exposed mice.Toxicology. 2008 Oct 30;252(1-3):86-91. doi: 10.1016/j.tox.2008.07.062. Epub 2008 Aug 7. Toxicology. 2008. PMID: 18755235
-
Role of lipid peroxidation and oxidative stress in alcohol toxicity.Free Radic Biol Med. 1989;7(5):537-9. doi: 10.1016/0891-5849(89)90029-4. Free Radic Biol Med. 1989. PMID: 2693222 Review. No abstract available.
Cited by
-
Feeding Strategies with Multi-Strain Probiotics Affect Growth, Health Condition, and Disease Resistance in Asian Seabass (Lates calcarifer).Probiotics Antimicrob Proteins. 2023 Dec 23. doi: 10.1007/s12602-023-10207-x. Online ahead of print. Probiotics Antimicrob Proteins. 2023. PMID: 38135810
-
An insight into the potent medicinal plant Phyllanthus amarus Schum. and Thonn.Nucleus (Calcutta). 2022;65(3):437-472. doi: 10.1007/s13237-022-00409-z. Epub 2022 Nov 12. Nucleus (Calcutta). 2022. PMID: 36407559 Free PMC article. Review.
-
Phyllanthus amarus extract restored deranged biochemical parameters in rat model of hepatotoxicity and nephrotoxicity.Heliyon. 2020 Dec 18;6(12):e05670. doi: 10.1016/j.heliyon.2020.e05670. eCollection 2020 Dec. Heliyon. 2020. PMID: 33364479 Free PMC article.
-
Effect of crocin, an active saffron constituent, on ethanol toxicity in the rat: histopathological and biochemical studies.Iran J Basic Med Sci. 2020 Jan;23(1):51-62. doi: 10.22038/IJBMS.2019.37133.8845. Iran J Basic Med Sci. 2020. PMID: 32405348 Free PMC article.
-
Effects of Phyllanthus amarus PHYLLPROTM leaves on hangover symptoms: a randomized, double-blind, placebo-controlled crossover study.Pharm Biol. 2019 Dec;57(1):145-153. doi: 10.1080/13880209.2019.1585460. Pharm Biol. 2019. PMID: 30922154 Free PMC article. Clinical Trial.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Research Materials
Miscellaneous