Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821

doi:10.1038/ja.2014.123

. 2015 Mar;68(3):185-90.

doi: 10.1038/ja.2014.123. Epub 2014 Sep 10.

Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821

Zhongyi Wan¹, Wei Fang², Liqiao Shi², Kaimei Wang², Yani Zhang², Zhigang Zhang², Zhaoyuan Wu², Ziwen Yang³, Yucheng Gu⁴

Affiliations

¹ College of Life Sciences, Wuhan University, Wuhan, PR China.
² National Engineering Research Center for Bio-pesticide, Hubei Academy of Agricultural Sciences, Wuhan, PR China.
³ 1] College of Life Sciences, Wuhan University, Wuhan, PR China [2] National Engineering Research Center for Bio-pesticide, Hubei Academy of Agricultural Sciences, Wuhan, PR China.
⁴ Syngenta Jealott's Hill International Research Centre, Bracknell, Berkshire, UK.

PMID: 25204346
DOI: 10.1038/ja.2014.123

Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821

Zhongyi Wan et al. J Antibiot (Tokyo). 2015 Mar.

. 2015 Mar;68(3):185-90.

doi: 10.1038/ja.2014.123. Epub 2014 Sep 10.

Authors

Zhongyi Wan¹, Wei Fang², Liqiao Shi², Kaimei Wang², Yani Zhang², Zhigang Zhang², Zhaoyuan Wu², Ziwen Yang³, Yucheng Gu⁴

Affiliations

¹ College of Life Sciences, Wuhan University, Wuhan, PR China.
² National Engineering Research Center for Bio-pesticide, Hubei Academy of Agricultural Sciences, Wuhan, PR China.
³ 1] College of Life Sciences, Wuhan University, Wuhan, PR China [2] National Engineering Research Center for Bio-pesticide, Hubei Academy of Agricultural Sciences, Wuhan, PR China.
⁴ Syngenta Jealott's Hill International Research Centre, Bracknell, Berkshire, UK.

PMID: 25204346
DOI: 10.1038/ja.2014.123

Abstract

Two new 32-membered macrolide compounds, named Novonestmycins A (1) and B (2), were isolated from the soil strain Streptomyces phytohabitans HBERC-20821. Their structures were elucidated by using spectroscopic methods, including 1D, 2D-NMR and MS spectrometry. The two compounds showed strong activities against the phytophathogenic fungi Corynespora cassiicola, Rhizoctonia solani and Septoria nodorum, with MIC values of 0.78, 0.39 and 0.78 μg ml(-1), respectively. In addition, the two compounds exhibited potent inhibitory activities against four different human tumor cell lines as well as one 5-FU-resistant human hepatocellular carcinoma cell line, with IC50 of 0.15-0.48 μg ml(-1) and 0.24-1.34 μg ml(-1), respectively.

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References

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[1] J Antibiot (Tokyo). 2009 Dec;62(12):699-702 - PubMed

[2] J Antibiot (Tokyo). 2009 Dec;62(12):699-702 - PubMed

[3] J Antibiot (Tokyo). 1986 Apr;39(4):502-9 - PubMed

[4] J Antibiot (Tokyo). 1986 Apr;39(4):502-9 - PubMed

[5] Mol Biol Evol. 1987 Jul;4(4):406-25 - PubMed

[6] Mol Biol Evol. 1987 Jul;4(4):406-25 - PubMed

[7] J Antibiot (Tokyo). 1997 Dec;50(12):1036-41 - PubMed

[8] J Antibiot (Tokyo). 1997 Dec;50(12):1036-41 - PubMed

[9] J Antibiot (Tokyo). 1995 Nov;48(11):1385-7 - PubMed

[10] J Antibiot (Tokyo). 1995 Nov;48(11):1385-7 - PubMed

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Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821

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Novonestmycins A and B, two new 32-membered bioactive macrolides from Streptomyces phytohabitans HBERC-20821

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