Serum levels of thyroid hormones and thyroid stimulating hormone in patients with biliogenic and hyperlipidaemic acute pancreatitis: Difference and value in predicting disease severity
- PMID: 26811409
- PMCID: PMC5580069
- DOI: 10.1177/0300060515618052
Serum levels of thyroid hormones and thyroid stimulating hormone in patients with biliogenic and hyperlipidaemic acute pancreatitis: Difference and value in predicting disease severity
Abstract
Objectives: To compare retrospectively serum levels of thyroid hormones (THs) and thyroid stimulating hormone (TSH) between patients with biliogenic acute pancreatitis (BAP) and those with hyperlipidaemic acute pancreatitis (HLAP), in order to assess their value for predicting the severity of acute pancreatitis (AP).
Methods: Patients with AP were divided into BAP and HLAP groups, then further divided into either a mild AP (MAP) group or a moderately severe AP (MSAP) group. Routine blood parameters were measured. Free tri-iodothyronine (FT3), free thyroxine (FT4) and TSH levels were measured.
Results: Seventy-six patients with AP were enrolled in the study. FT3 and TSH levels were significantly higher in patients with MAP than in patients with MSAP. FT4 and TSH levels were significantly lower in the HLAP group than in the BAP group. TSH levels in both MAP and MSAP patients were significantly lower in the HLAP group than in the BAP group. TSH was inversely correlated with triglyceride levels in patients with HLAP. FT3 was a risk factor for MSAP in patients with AP and also demonstrated moderate accuracy in predicting AP severity.
Conclusions: THs and TSH decrease with the severity of AP, especially in patients with HLAP. FT3 may be a useful biomarker for the early assessment of the severity of AP.
Keywords: Hyperlipidaemic acute pancreatitis; acute pancreatitis; biliogenic acute pancreatitis; severity; thyroid hormones; thyroid stimulating hormone.
© The Author(s) 2016.
Similar articles
-
Association between thyroid hormone levels in the acute stage of stroke and risk of poststroke depression: A meta-analysis.Brain Behav. 2024 Jan;14(1):e3322. doi: 10.1002/brb3.3322. Brain Behav. 2024. PMID: 38189637 Free PMC article. Review.
-
The clinical characteristic of alcohol-hyperlipidemia etiologically complex type of acute pancreatitis.Eur Rev Med Pharmacol Sci. 2022 Oct;26(19):7212-7218. doi: 10.26355/eurrev_202210_29913. Eur Rev Med Pharmacol Sci. 2022. PMID: 36263531 Review.
-
Low FT3 is a valuable predictor of severe acute pancreatitis in the emergency department.J Dig Dis. 2018 Jul;19(7):431-438. doi: 10.1111/1751-2980.12609. Epub 2018 Jul 3. J Dig Dis. 2018. PMID: 29802762
-
Thyroid hormones and diabetic nephropathy: An essential relationship to recognize.Nephrology (Carlton). 2019 Feb;24(2):160-169. doi: 10.1111/nep.13388. Nephrology (Carlton). 2019. PMID: 29660205
-
Antithrombin III and D-dimer levels as indicators of disease severity in patients with hyperlipidaemic or biliary acute pancreatitis.J Int Med Res. 2017 Feb;45(1):147-158. doi: 10.1177/0300060516677929. Epub 2017 Jan 12. J Int Med Res. 2017. PMID: 28222624 Free PMC article.
Cited by
-
Nonthyroidal illness syndrome in acute pancreatitis patients: an 8-year cohort study.BMC Gastroenterol. 2022 Feb 3;22(1):40. doi: 10.1186/s12876-022-02111-5. BMC Gastroenterol. 2022. PMID: 35114934 Free PMC article.
-
Associations of Habitual Mineral Intake with New-Onset Prediabetes/Diabetes after Acute Pancreatitis.Nutrients. 2021 Nov 8;13(11):3978. doi: 10.3390/nu13113978. Nutrients. 2021. PMID: 34836234 Free PMC article.
References
-
- Klöppel G. Acute pancreatitis. Semin Diagn Pathol 2004; 21: 221–226. - PubMed
-
- Wijffels NA, van Walraven LA, Ophof PJ, et al. Late development of pancreas necrosis during acute pancreatitis: an underestimated phenomenon associated with high morbidity and mortality. Pancreas 2007; 34: 215–219. - PubMed
-
- van Geenen EJ, van derPeet DL, Bhagirath P, et al. Etiology and diagnosis of acute biliary pancreatitis. Nat Rev Gastroenterol Hepatol 2010; 7: 495–502. - PubMed
-
- Athyros VG, Giouleme OI, Nikolaidis NL, et al. Long-term follow-up of patients with acute hypertriglyceridemia-induced pancreatitis. J Clin Gastroenterol 2002; 34: 472–475. - PubMed
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical