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Randomized Controlled Trial
. 2022 Oct;45(10):1991-1997.
doi: 10.1007/s40618-022-01833-3. Epub 2022 Jun 17.

Effects of combined physical exercise on plasma lipid variables, paraoxonase 1 activity, and inflammation parameters in adults with obesity: a randomized clinical trial

A R Streb  1 , P G S Braga  2 , R F de Melo  3 , L J Botelho  4 , R C Maranhão  2 , G F Del Duca  5
Affiliations
Randomized Controlled Trial

Effects of combined physical exercise on plasma lipid variables, paraoxonase 1 activity, and inflammation parameters in adults with obesity: a randomized clinical trial

A R Streb et al. J Endocrinol Invest. 2022 Oct.

Abstract

Objective: We aimed to investigate whether combined physical exercise may affect plasma lipid variables, paraoxonase 1 (PON1) activity, and inflammation parameters in adults with obesity.

Methods: Thirty-six participants were recruited to complete the study protocol. The mean age was 37 ± 1 years, and the baseline body mass index was 33.0 ± 0.4 kg/m2. Participants were allocated to the control group (CG) and the exercise group (EG). The EG performed three weekly sessions of combined physical exercise for 16 weeks. Plasma lipid variables, PON1 activity, and inflammatory profile were determined before and after intervention.

Results: Total cholesterol levels decreased in both groups, without intergroup difference (time p = 0.001). Non-high-density lipoprotein cholesterol (HDL-C) levels decreased in both groups (time p = 0.001); however, they were lower in the EG than in the CG (p = 0.038). The EG had increased HDL-C levels, but the CG had decreased HDL-C levels (time*group p = 0.011). PON1 activity was reduced in both groups (time, p = 0.001). The Castelli risk Index I and II reduced in the EG and increased in the CG (time*group, p = 0.008 and p = 0.011, respectively). The inflammatory markers were not modified.

Conclusion: Adults with obesity may benefit from regular practice of combined physical exercise training in many metabolic aspects that are related to protection against the development of cardiovascular disease.

Keywords: Cardiovascular diseases; Exercise training; Metabolism; Obesity; Risk factors.

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References

    1. Kivimäki M, Kuosma E, Ferrie JE, Luukkonen R, Nyberg ST, Alfredsson L et al (2017) Overweight, obesity, and risk of cardiometabolic multimorbidity: pooled analysis of individual-level data for 120 813 adults from 16 cohort studies from the USA and Europe. Lancet Public Health 2:e277–e285. https://doi.org/10.1016/S2468-2667(17)30074-9 - DOI - PubMed - PMC
    1. Oliveira MRM, Maranhão RC (2004) Relationships in women between body mass index and the intravascular metabolism of chylomicron-like emulsions. Int J Obes Relat Metab Disord 28:1471–1478. https://doi.org/10.1038/sj.ijo.0802780 - DOI - PubMed
    1. Bora K, Pathak MS, Borah P, Das D (2017) Association of Decreased High-Density Lipoprotein Cholesterol (HDL-C) With Obesity and Risk Estimates for Decreased HDL-C Attributable to Obesity. J Prim Care Community Health 8:26–30. https://doi.org/10.1177/2150131916664706 - DOI - PubMed
    1. Nystoriak MA, Bhatnagar A (2018) Cardiovascular effects and benefits of exercise. Front Cardiovasc Med. https://doi.org/10.3389/fcvm.2018.00135 - DOI - PubMed - PMC
    1. Välimäki IA, Vuorimaa T, Ahotupa M, Vasankari T (2016) Effect of continuous and intermittent exercises on oxidised HDL and LDL lipids in runners. Int J Sports Med 37:1103–1109. https://doi.org/10.1055/s-0042-114703 - DOI - PubMed

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