Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
- PMID: 36838560
- PMCID: PMC9965357
- DOI: 10.3390/molecules28041574
Redox Biomarkers Assessment after Oral Administration of Wine Extract and Grape Stem Extract in Rats and Mice
Abstract
Wine and by-products of the winemaking process, such as grape stems, are rich in bioactive polyphenolic compounds that might be beneficial for animal and human health. In recent years, the administration of dietary polyphenols with strong antioxidant and cytoprotective properties has constituted an emerging line of research interest toward disease prevention. However, in scientific literature, only a limited number of studies have investigated the safety and the toxicological risks of polyphenolic compounds in vivo. Based on the above, the purpose of the present study was two-fold: first, to examine the effects of oral administration of a grape stem extract, derived from the Greek red wine Mavrodaphne, on mice redox biomarkers; and second, to investigate the biological effects of oral administration of a wine extract, derived from the emblematic Greek red wine Xinomavro, on rats. Toward this purpose, body weight, growth rate, hematological, biochemical, and histopathological parameters, as well as a panel of redox biomarkers, were examined. According to our results, the administration of Mavrodaphne grape stem extract in mice induced alterations in redox homeostasis, preventing mice from the adverse effects of lipid peroxidation. Contrariwise, the administration of Xinomavro wine extract induced both beneficial and harmful outcomes on rat redox status determined by the examined tissue. Collectively, our study reports that the Mavrodaphne grape stem extract, a serious pollutant when disposed in environmental matrices, is an important source of bioactive polyphenolic compounds that could protect from oxidative damage and improve animal and human health. Finally, the Xinomavro wine extract exerts tissue-specific changes in redox balance, which are indicative of the complexity that characterizes the biological systems.
Keywords: antioxidants; polyphenols; redox biomarkers; toxicological study; wine extract.
Conflict of interest statement
The authors declare no conflict of interest.
Figures
Similar articles
-
Grape Stem Extracts From Three Native Greek Vine Varieties Exhibit Strong Antioxidant and Antimutagenic Properties.Anticancer Res. 2020 Apr;40(4):2025-2032. doi: 10.21873/anticanres.14159. Anticancer Res. 2020. PMID: 32234893
-
The effects of grape and red wine polyphenols on gut microbiota - A systematic review.Food Res Int. 2018 Nov;113:277-287. doi: 10.1016/j.foodres.2018.07.019. Epub 2018 Jul 11. Food Res Int. 2018. PMID: 30195522
-
Grape and wine polymeric polyphenols: Their importance in enology.Crit Rev Food Sci Nutr. 2019;59(4):563-579. doi: 10.1080/10408398.2017.1381071. Epub 2017 Oct 20. Crit Rev Food Sci Nutr. 2019. PMID: 28933917 Review.
-
Functional Properties of Grape and Wine Polyphenols.Plant Foods Hum Nutr. 2015 Dec;70(4):454-62. doi: 10.1007/s11130-015-0518-1. Plant Foods Hum Nutr. 2015. PMID: 26547323 Review.
-
Red grape skin and seeds polyphenols: Evidence of their protective effects on endothelial progenitor cells and improvement of their intestinal absorption.Eur J Pharm Biopharm. 2012 Jan;80(1):176-84. doi: 10.1016/j.ejpb.2011.09.002. Epub 2011 Sep 24. Eur J Pharm Biopharm. 2012. PMID: 21971368
References
-
- Facinó R., Carini M., Aldini G., Berti F., Rossoni G., Bombardelli E., Morazzoni P. Procyanidines from Vitis vinifera Seeds Protect Rabbit Heart from Ischemia/Reperfusion Injury: Antioxidant Intervention and/or Iron and Copper Sequestering Ability. Planta Med. 1996;62:495–502. doi: 10.1055/s-2006-957956. - DOI - PubMed
-
- Bagchi D., Garg A., Krohn R.L., Bagchi M., Tran M.X., Stohs S.J. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res. Commun. Mol. Pathol. Pharmacol. 1997;95:179–189. - PubMed
-
- Bagchi D., Garg A., Krohn R.L., Bagchi M., Bagchi D.J., Balmoori J., Stohs S.J. Protective Effects of Grape Seed Proanthocyanidins and Selected Antioxidants against TPA-Induced Hepatic and Brain Lipid Peroxidation and DNA Fragmentation, and Peritoneal Macrophage Activation in Mice. Gen. Pharmacol. 1998;30:771–776. doi: 10.1016/S0306-3623(97)00332-7. - DOI - PubMed
-
- Zafirov D., Bredy-Dobreva G., Litchev V., Papasova M. Antiexudative and capillaritonic effects of procyanidines isolated from grape seeds (V. vinifera) Acta Physiol. Pharmacol. Bulg. 1990;16:50–54. - PubMed
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources