Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise
- PMID: 3989240
- DOI: 10.1093/geronj/40.3.281
Superoxide dismutase and catalase in skeletal muscle: adaptive response to exercise
Abstract
Cellular damage caused by free radical reactions may play a role in the aging process. A bout of exercise can increase free radical concentration with damage to mitochondria in muscle (Davies et al., 1982). This study was undertaken to determine if muscle adapts to exercise training with an enhancement of enzymatic defenses against free radical damage. A program of running that induced two-fold increases in mitochondrial enzymes in leg muscles of rats resulted in no increase in catalase or cytoplasmic superoxide dismutase (SOD) activities. Mitochondrial SOD activity was increased 37% in fast-twitch red and slow-twitch red types of muscle and 14% in white muscle. Thus, despite an increase in mitochondrial SOD, the ratio of SOD to mitochondrial citrate cycle and respiratory chain enzymes was decreased. It seems unlikely that increased capacity for enzymatic scavenging of superoxide radical is a major protective adaptation against free radical damage in exercise-trained muscle.
Similar articles
-
Superoxide dismutase, catalase, and glutathione peroxidase activities in muscle and lymphoid organs of sedentary and exercise-trained rats.Physiol Behav. 1994 Nov;56(5):1095-9. doi: 10.1016/0031-9384(94)90349-2. Physiol Behav. 1994. PMID: 7824577
-
Lipid peroxidation and scavenger enzymes during exercise: adaptive response to training.J Appl Physiol (1985). 1988 Apr;64(4):1333-6. doi: 10.1152/jappl.1988.64.4.1333. J Appl Physiol (1985). 1988. PMID: 3378967
-
Antioxidant enzyme systems in rat liver and skeletal muscle. Influences of selenium deficiency, chronic training, and acute exercise.Arch Biochem Biophys. 1988 May 15;263(1):150-60. doi: 10.1016/0003-9861(88)90623-6. Arch Biochem Biophys. 1988. PMID: 3369860
-
Alteration of antioxidant enzymes with aging in rat skeletal muscle and liver.Am J Physiol. 1990 Apr;258(4 Pt 2):R918-23. doi: 10.1152/ajpregu.1990.258.4.R918. Am J Physiol. 1990. PMID: 2331035
-
Dehydroepiandrosterone and a beta-agonist, energy transducers, alter antioxidant enzyme systems: influence of chronic training and acute exercise in rats.Arch Biochem Biophys. 1990 Dec;283(2):503-11. doi: 10.1016/0003-9861(90)90674-n. Arch Biochem Biophys. 1990. PMID: 1980404
Cited by
-
Exercise-Mediated Protection against Air Pollution-Induced Immune Damage: Mechanisms, Challenges, and Future Directions.Biology (Basel). 2024 Apr 8;13(4):247. doi: 10.3390/biology13040247. Biology (Basel). 2024. PMID: 38666859 Free PMC article. Review.
-
Expression of mitochondrial oxidative stress response genes in muscle is associated with mitochondrial respiration, physical performance, and muscle mass in the Study of Muscle, Mobility and Aging (SOMMA).medRxiv [Preprint]. 2023 Nov 6:2023.11.05.23298108. doi: 10.1101/2023.11.05.23298108. medRxiv. 2023. Update in: Aging Cell. 2024 Jun;23(6):e14114. doi: 10.1111/acel.14114. PMID: 37986804 Free PMC article. Updated. Preprint.
-
Exercise Training and Skeletal Muscle Antioxidant Enzymes: An Update.Antioxidants (Basel). 2022 Dec 25;12(1):39. doi: 10.3390/antiox12010039. Antioxidants (Basel). 2022. PMID: 36670901 Free PMC article. Review.
-
Physical activity and sperm quality: influence in sperm donors.Reprod Biol Endocrinol. 2022 May 24;20(1):83. doi: 10.1186/s12958-022-00946-x. Reprod Biol Endocrinol. 2022. PMID: 35610619 Free PMC article.
-
Physical Activity in Polluted Air-Net Benefit or Harm to Cardiovascular Health? A Comprehensive Review.Antioxidants (Basel). 2021 Nov 8;10(11):1787. doi: 10.3390/antiox10111787. Antioxidants (Basel). 2021. PMID: 34829658 Free PMC article. Review.