Age changes in neuromuscular junction morphology and acetylcholine receptor distribution on rat skeletal muscle fibres
- PMID: 7320945
- PMCID: PMC1244058
- DOI: 10.1113/jphysiol.1981.sp013960
Age changes in neuromuscular junction morphology and acetylcholine receptor distribution on rat skeletal muscle fibres
Abstract
1. Neuromuscular junctions in the sternomastoid muscles of female Lewis rats were examined in animals up to 917 d old. 2. The average number of myelinated branches of terminal axons entering a junction increased with age of the animal, up to 400 d. This change could be described by a simple kinetic model which assumed that there was no influence of age on the ability of motoneurones to produce or maintain terminal branches, but that axons could produce or maintain only a limited number of branches. 3. There was a change in the over-all junctional length with age, but there was a significant increase in the number of discrete regions of high ACh receptor density in junctions from older animals. 4. There was a gradual decrease in the number of ACh receptors per junction with age after about 500 d, and muscles from some rats older than 500 d had detectable numbers of extrajunctional ACh receptors. 5. The changes in the neuromuscular junction with increased age occurred gradually over adult life.
Similar articles
-
Age changes of motor innervation and acetylcholine receptor distribution on human skeletal muscle fibres.J Neurol Sci. 1984 Nov-Dec;66(2-3):327-38. doi: 10.1016/0022-510x(84)90021-2. J Neurol Sci. 1984. PMID: 6530617
-
Channel gating at frog neuromuscular junctions formed by different cholinergic neurones.J Physiol. 1981 Mar;312:237-52. doi: 10.1113/jphysiol.1981.sp013626. J Physiol. 1981. PMID: 6267263 Free PMC article.
-
Acetylcholine receptor kinetics.J Membr Biol. 1981 Feb 28;58(3):161-74. doi: 10.1007/BF01870902. J Membr Biol. 1981. PMID: 6260951 Review. No abstract available.
-
Acetylcholine sensitivity of developing ectopic nerve-muscle junctions in adult rat soleus muscles.J Physiol. 1980 Jun;303:173-89. doi: 10.1113/jphysiol.1980.sp013279. J Physiol. 1980. PMID: 6253618 Free PMC article.
-
Control of acetylcholine receptors in skeletal muscle.Physiol Rev. 1979 Jan;59(1):165-227. doi: 10.1152/physrev.1979.59.1.165. Physiol Rev. 1979. PMID: 375254 Review.
Cited by
-
Unraveling the causes of sarcopenia: Roles of neuromuscular junction impairment and mitochondrial dysfunction.Physiol Rep. 2024 Jan;12(1):e15917. doi: 10.14814/phy2.15917. Physiol Rep. 2024. PMID: 38225199 Free PMC article. Review.
-
Neuromuscular junction transmission failure in aging and sarcopenia: The nexus of the neurological and muscular systems.Ageing Res Rev. 2023 Aug;89:101966. doi: 10.1016/j.arr.2023.101966. Epub 2023 Jun 1. Ageing Res Rev. 2023. PMID: 37270145 Review.
-
Biomarkers of aging.Sci China Life Sci. 2023 May;66(5):893-1066. doi: 10.1007/s11427-023-2305-0. Epub 2023 Apr 11. Sci China Life Sci. 2023. PMID: 37076725 Free PMC article. Review.
-
Structure and Function of the Mammalian Neuromuscular Junction.Compr Physiol. 2022 Aug 11;12(4):3731-3766. doi: 10.1002/cphy.c210022. Compr Physiol. 2022. PMID: 35950651 Free PMC article.
-
Adaptive Remodeling of the Neuromuscular Junction with Aging.Cells. 2022 Mar 29;11(7):1150. doi: 10.3390/cells11071150. Cells. 2022. PMID: 35406714 Free PMC article. Review.
References
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical