Local frequency dependence in transcranial ultrasound transmission

PJ White, GT Clement, K Hynynen - Physics in Medicine & …, 2006 - iopscience.iop.org
The development of large-aperture multiple-source transducer arrays for ultrasound
transmission through the human skull has demonstrated the possibility of controlled and …

Demonstration of potential noninvasive ultrasound brain therapy through an intact skull

K Hynynen, FA Jolesz - Ultrasound in medicine & biology, 1998 - Elsevier
Utilization of therapeutic ultrasound in the brain has been seriously limited by the commonly
accepted view that these exposures would require that a piece of the skull bone be removed …

Characterization of ultrasound propagation through ex-vivo human temporal bone

AY Ammi, TD Mast, IH Huang, TA Abruzzo… - Ultrasound in medicine …, 2008 - Elsevier
Adjuvant therapies that lower the thrombolytic dose or increase its efficacy would represent
a significant breakthrough in the treatment of patients with ischemic stroke. The objective of …

Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range

A Hughes, K Hynynen - Physics in Medicine & Biology, 2017 - iopscience.iop.org
The use of a phased array of ultrasound transducer elements to sonicate through the skull
has opened the way for new treatments and the delivery of therapeutics beyond the blood …

The role of internal reflection in transskull phase distortion

GT Clement, J Sun, K Hynynen - Ultrasonics, 2001 - Elsevier
Phase distortion due to reflection in transcranial ultrasound propagation is investigated.
Understanding of these phase-dependent properties is motivated by efforts to construct a …

Observation of guided acoustic waves in a human skull

H Estrada, S Gottschalk, M Reiss… - Ultrasound in medicine …, 2018 - Elsevier
Human skull poses a significant barrier for the propagation of ultrasound waves.
Development of methods enabling more efficient ultrasound transmission into and from the …

Investigation of a large-area phased array for focused ultrasound surgery through the skull

GT Clement, J White, K Hynynen - Physics in Medicine & Biology, 2000 - iopscience.iop.org
Non-invasive treatment of brain disorders using ultrasound would require a transducer array
that can propagate ultrasound through the skull and still produce sufficient acoustic pressure …

A Magnetic Resonance Imaging–Compatible, Large‐Scale Array for Trans‐Skull Ultrasound Surgery and Therapy

GT Clement, PJ White, RL King… - Journal of ultrasound …, 2005 - Wiley Online Library
Objective Advances in ultrasound transducer array and amplifier technologies have
prompted many intriguing scientific proposals for ultrasound therapy. These include both …

Adaptive focusing for transcranial ultrasound imaging using dual arrays

F Vignon, JF Aubry, M Tanter, A Margoum… - The Journal of the …, 2006 - pubs.aip.org
Ultrasonic brain imaging remains difficult and limited because of the strong aberrating
effects of the skull (absorption, diffusion and refraction of ultrasounds): high resolution …

Acoustic properties across the human skull

TS Riis, TD Webb, J Kubanek - Ultrasonics, 2022 - Elsevier
Transcranial ultrasound is emerging as a noninvasive tool for targeted treatments of brain
disorders. Transcranial ultrasound has been used for remotely mediated surgeries, transient …