A Magnetic Resonance Imaging–Compatible, Large‐Scale Array for Trans‐Skull Ultrasound Surgery and Therapy
Objective Advances in ultrasound transducer array and amplifier technologies have
prompted many intriguing scientific proposals for ultrasound therapy. These include both …
prompted many intriguing scientific proposals for ultrasound therapy. These include both …
Trans-skull ultrasound therapy: The feasibility of using image-derived skull thickness information to correct the phase distortion
K Hynynen, J Sun - IEEE transactions on ultrasonics …, 1999 - ieeexplore.ieee.org
Recent papers have shown that focused ultrasound therapy may be feasible in the brain
through an intact human skull by using phased arrays to correct the phase distortion induced …
through an intact human skull by using phased arrays to correct the phase distortion induced …
A hemisphere array for non-invasive ultrasound brain therapy and surgery
GT Clement, J Sun, T Giesecke… - Physics in Medicine & …, 2000 - iopscience.iop.org
Ultrasound phased arrays may offer a method for non-invasive deep brain surgery through
the skull. In this study a hemispherical phased array system is developed to test the …
the skull. In this study a hemispherical phased array system is developed to test the …
Investigation of a large-area phased array for focused ultrasound surgery through the skull
GT Clement, J White, K Hynynen - Physics in Medicine & Biology, 2000 - iopscience.iop.org
Non-invasive treatment of brain disorders using ultrasound would require a transducer array
that can propagate ultrasound through the skull and still produce sufficient acoustic pressure …
that can propagate ultrasound through the skull and still produce sufficient acoustic pressure …
500‐element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls
The aim of this study was to test a prototype MRI‐compatible focused ultrasound phased
array system for trans‐skull brain tissue ablation. Rabbit thigh muscle and brain were …
array system for trans‐skull brain tissue ablation. Rabbit thigh muscle and brain were …
A non-invasive method for focusing ultrasound through the human skull
GT Clement, K Hynynen - Physics in medicine & biology, 2002 - iopscience.iop.org
A technique for focusing ultrasound through the human skull is described and verified. The
approach is based on a layered wavevector-frequency domain model, which propagates …
approach is based on a layered wavevector-frequency domain model, which propagates …
Demonstration of potential noninvasive ultrasound brain therapy through an intact skull
Utilization of therapeutic ultrasound in the brain has been seriously limited by the commonly
accepted view that these exposures would require that a piece of the skull bone be removed …
accepted view that these exposures would require that a piece of the skull bone be removed …
Design of patient-specific focused ultrasound arrays for non-invasive brain therapy with increased trans-skull transmission and steering range
A Hughes, K Hynynen - Physics in Medicine & Biology, 2017 - iopscience.iop.org
The use of a phased array of ultrasound transducer elements to sonicate through the skull
has opened the way for new treatments and the delivery of therapeutics beyond the blood …
has opened the way for new treatments and the delivery of therapeutics beyond the blood …
Transcranial ultrasound focus reconstruction with phase and amplitude correction
J White, GT Clement, K Hynynen - ieee transactions on …, 2005 - ieeexplore.ieee.org
Therapeutic and diagnostic ultrasound procedures performed noninvasively through the
skull require a reliable method for maintaining acoustic focus integrity after transmission …
skull require a reliable method for maintaining acoustic focus integrity after transmission …
MRI‐guided focused ultrasound surgery in the brain: Tests in a primate model
N McDannold, M Moss, R Killiany… - … in Medicine: An …, 2003 - Wiley Online Library
MRI‐guided focused ultrasound was tested in the brains of rhesus monkeys. Locations up to
4.8 cm deep were targeted. Focal heating was observed in all cases with MRI‐derived …
4.8 cm deep were targeted. Focal heating was observed in all cases with MRI‐derived …